Fig. 2

Cellular uptake of Hm@TSA/As-MOF. The uptake of free C6, C6-MOF and Hm@C6-MOF by bEnd.3 cells was examined via fluorescence microscopy (A) (scale bar = 50 μm) and flow cytometry (B). The mechanism underlying the uptake of Hm@C6-MOF by bEnd.3 cells was identified through a competitive inhibition experiment (n = 3) (C). The uptake of free C6, C6-MOF and Hm@C6-MOF by CTLL-2 cells was examined via fluorescence microscopy (D) (scale bar = 50 μm) and flow cytometry (E). The mechanism underlying the uptake of Hm@C6-MOF by CTLL-2 cells was identified through a competitive inhibition experiment (n = 3) (F). The uptake of free C6, C6-MOF and Hm@C6-MOF by H22 cells was examined via fluorescence microscopy (G) (scale bar = 50 μm) and flow cytometry (H). The mechanism underlying the uptake of Hm@C6-MOF by H22 cells was identified via a competitive inhibition experiment (n = 3) (I). Data are expressed as the mean ± SD (*, p < 0.05; **, p < 0.01; ***, p < 0.001; two-tailed Student’s t-test)