Fig. 7

Hm@TSA/As-MOF upregulated the activity of TILs by decreasing the levels of TGF-β1. The levels of TGF-β1 (A), IL10 (B), and IL6 (B) in tumour tissues were evaluated via immunofluorescence staining (scale bar = 50 μm). The proportion of T-bet⁺ (C) and Emoes⁺ TILs (D) in CD8⁺ TILs was evaluated via flow cytometry (n = 3). The levels of IFN-γ⁺CD8⁺ TILs (E) and Granzyme B⁺CD8⁺ TILs (F) in tumour tissues were evaluated via immunofluorescence staining (scale bar = 20 μm). Data are expressed as the mean ± SD (*, p < 0.05; **, p < 0.01; ***, p < 0.001; two-tailed Student’s t-test)