Figure 5
The effect of microglial inhibition on hyperphosphorylated tau is age dependent. Staining of hyperphosphorylated tau by AT8 revealed significant differences in neurons containing hyperphosphorylated tau. At age 3.5 months injecting the conjugated fibrin γ377-395 peptide (B) led to an increase in the number of cells containing hyperphosphorylated tau compared with control (A), (n = 5 mice, 160 areas). In contrast, at age 6 months, a decrease in the number of hyperphosphorylated tau was observed when comparing the conjugated fibrin γ377-395 peptide (D) with control (C), (n = 6 mice, 133 areas). Scale bar: 50 μm.