Kalishwaralal Kalimuthu and colleagues have been awarded the Journal of Nanobiotechnology article of the year (2018):
Gold nanoparticles stabilize peptide-drug-conjugates for sustained targeted drug delivery to cancer cells
Delivery of cytotoxic drugs to cancer cells, without harming healthy cells, can be targeted using peptide drug conjugates (PDCs). However, PDCs are relatively unstable and so Kalimuthu and colleagues identified novel peptides and improved the PDC half-life, by conjugating them to gold nanoparticles, opening possibilities for slow release formulations.
Lead investigator, Prof Michael Firer, explained that "this study broadens the applications for gold nanoparticles by using them as stabilizers for drug delivery systems, which could lead to improved pharmacokinetic drug profiles."