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  1. Fracture incidence increases with ageing and other contingencies. However, the strategy of accelerating fracture repair in clinical therapeutics remain a huge challenge due to its complexity and a long-lasting...

    Authors: Shunhao Wang, Jiahuang Qiu, Anyi Guo, Ruanzhong Ren, Wei He, Sijin Liu and Yajun Liu

    Citation: Journal of Nanobiotechnology 2020 18:84

    Content type: Research

    Published on:

  2. Breast cancer lung metastasis occurs in more than 60% of all patients with breast cancer, and most of those afflicted by it eventually die of recurrence. The tumor microenvironment plays vital roles in metasta...

    Authors: Ying Liu, Xingmei Xie, Xuefeng Hou, Junyi Shen, Jiangpei Shi, Haizhen Chen, Yuanzhi He, Zhi Wang and Nianping Feng

    Citation: Journal of Nanobiotechnology 2020 18:83

    Content type: Research

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  3. Dysfunction of human respiratory and electro-cardiac activities could affect the ability of the heart to pump blood and the lungs to inhale oxygen. Thus, a device could simultaneously measure electro-cardiac s...

    Authors: Li Wang, Feng Zhang, Kechao Lu, Mohammed Abdulaziz, Chao Li, Chongyu Zhang, Jun Chen and Yunlun Li

    Citation: Journal of Nanobiotechnology 2020 18:82

    Content type: Research

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  4. Bacterial biofilms are communities of surface-associated microorganisms living in cellular clusters or micro-colonies, encapsulated in a complex matrix composed of an extracellular polymeric substance, separat...

    Authors: Ella Yeor-Davidi, Marina Zverzhinetsky, Vadim Krivitsky and Fernando Patolsky

    Citation: Journal of Nanobiotechnology 2020 18:81

    Content type: Research

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  5. Psoriasis is a chronic immune-mediated inflammatory skin disease without effective treatment. The utilization of all trans-retinoic acid (TRA) and betamethasone (BT) for the treatment of psoriasis is still fac...

    Authors: Wei Wang, Gao-feng Shu, Kong-jun Lu, Xiao-ling Xu, Min-cheng Sun, Jing Qi, Qiao-ling Huang, Wei-qiang Tan and Yong-zhong Du

    Citation: Journal of Nanobiotechnology 2020 18:80

    Content type: Research

    Published on:

  6. An amendment to this paper has been published and can be accessed via the original article.

    Authors: K. Marycz, P. Sobierajska, M. Roecken, K. Kornicka-Garbowska, M. Kępska, R. Idczak, J.-M. Nedelec and R. J. Wiglusz

    Citation: Journal of Nanobiotechnology 2020 18:79

    Content type: Correction

    Published on:

    The original article was published in Journal of Nanobiotechnology 2020 18:33

  7. An amendment to this paper has been published and can be accessed via the original article.

    Authors: Jiayi Gu, Yuming Chen, Ling Tong, Xueling Wang, Dehong Yu and Hao Wu

    Citation: Journal of Nanobiotechnology 2020 18:78

    Content type: Correction

    Published on:

    The original article was published in Journal of Nanobiotechnology 2020 18:53

  8. Most nanoparticles (NPs) reportedly block autophagic flux, thereby upregulating p62/SQSTM1 through degradation inhibition. p62 also acts as a multifunctional scaffold protein with multiple domains, and is invo...

    Authors: Yifan Wu, Yang Jin, Tianyu Sun, Piaoyu Zhu, Jinlong Li, Qinglin Zhang, Xiaoke Wang, Junkang Jiang, Gang Chen and Xinyuan Zhao

    Citation: Journal of Nanobiotechnology 2020 18:77

    Content type: Research

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  9. Formation of muscular pseudo-tissue depends on muscle precursor cells, the extracellular matrix (ECM)-mimicking structure and factors stimulating cell differentiation. These three things cooperate and can crea...

    Authors: Marlena Zielińska-Górska, Anna Hotowy, Mateusz Wierzbicki, Jaśmina Bałaban, Malwina Sosnowska, Sławomir Jaworski, Barbara Strojny, André Chwalibog and Ewa Sawosz

    Citation: Journal of Nanobiotechnology 2020 18:76

    Content type: Research

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  11. Nordihydroguaiaretic acid (NDGA) is a plant lignan obtained from creosote bush, known to possess anti-oxidant, anti-cancer and anti-viral activities and is being used in traditional medicine. However, toxicity...

    Authors: Geraldine Sandana Mala John, Veena Kumari Vuttaradhi, Satoru Takeuchi, Ravi Shankar Pitani, Ganesh Venkatraman and Suresh Kumar Rayala

    Citation: Journal of Nanobiotechnology 2020 18:74

    Content type: Research

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  12. Dual inhibitors of the 5-lipoxygenase-activating protein (FLAP) and the microsomal prostaglandin E2 synthase-1 (mPGES-1) may exert better anti-inflammatory efficacy and lower risks of adverse effects versus non-s...

    Authors: Blerina Shkodra-Pula, Christian Kretzer, Paul M. Jordan, Paul Klemm, Andreas Koeberle, David Pretzel, Erden Banoglu, Stefan Lorkowski, Maria Wallert, Stephanie Höppener, Steffi Stumpf, Antje Vollrath, Stephanie Schubert, Oliver Werz and Ulrich S. Schubert

    Citation: Journal of Nanobiotechnology 2020 18:73

    Content type: Research

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  13. Spinal cord injury (SCI) has a very disabling central nervous system impact but currently lacks effective treatment. Bone marrow-derived macrophages (BMDMs) are recruited to the injured area after SCI and part...

    Authors: Jiaxing Wang, Yuluo Rong, Chengyue Ji, Chengtang Lv, Dongdong Jiang, Xuhui Ge, Fangyi Gong, Pengyu Tang, Weihua Cai, Wei Liu and Jin Fan

    Citation: Journal of Nanobiotechnology 2020 18:72

    Content type: Research

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  14. Although many therapeutic strategies for Alzheimer’s disease (AD) have been explored, these strategies are seldom used in the clinic. Therefore, AD therapeutic research is still urgently needed. One major chal...

    Authors: Chunhong Gao, Xiaoyang Chu, Wei Gong, Jinpeng Zheng, Xiangyang Xie, Yuli Wang, Meiyan Yang, Zhiping Li, Chunsheng Gao and Yang Yang

    Citation: Journal of Nanobiotechnology 2020 18:71

    Content type: Research

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  15. The most convenient circulating tumor cells (CTCs) identification method is direct analysis of cells under bright field microscopy by which CTCs can be comprehensive studied based on morphology, phenotype or e...

    Authors: Shuibing Wang, Shaoli Hong, Shijia Cai, Jia Lei, Jinyao Chen, Nangang Zhang, Zhao Ai, Kan Liu and Man Tang

    Citation: Journal of Nanobiotechnology 2020 18:70

    Content type: Research

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  16. Cell-bound membrane vesicles (CBMVs) are a type of membrane vesicles different from the well-known extracellular vesicles (EVs). In recent years, the applications of EVs as drug delivery systems have been stud...

    Authors: Yang Zhang, Yang Liu, Wendiao Zhang, Qisheng Tang, Yun Zhou, Yuanfang Li, Tong Rong, Huaying Wang and Yong Chen

    Citation: Journal of Nanobiotechnology 2020 18:69

    Content type: Research

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  17. Enhancing angiogenesis is critical for accelerating wound healing. Application of different types of exosomes (Exos) to promote angiogenesis represents a novel strategy for enhanced wound repair. Saliva is kno...

    Authors: Bobin Mi, Lang Chen, Yuan Xiong, Chenchen Yan, Hang Xue, Adriana C. Panayi, Jing Liu, Liangcong Hu, Yiqiang Hu, Faqi Cao, Yun Sun, Wu Zhou and Guohui Liu

    Citation: Journal of Nanobiotechnology 2020 18:68

    Content type: Research

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  18. Exenatide is an insulinotropic peptide drug for type 2 diabetes treatment with low risk of hypoglycemia, and is administrated by subcutaneous injection. Oral administration is the most preferred route for life...

    Authors: Xiaoyan Bao, Kang Qian and Ping Yao

    Citation: Journal of Nanobiotechnology 2020 18:67

    Content type: Research

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  19. Osteoblast differentiation is a vital process for fracture healing, and exosomes are nanosized membrane vesicles that can deliver therapeutic drugs easily and safely. Macrophages participate in the regulation ...

    Authors: Yuan Xiong, Lang Chen, Chenchen Yan, Wu Zhou, Tao Yu, Yun Sun, Faqi Cao, Hang Xue, Yiqiang Hu, Dong Chen, Bobin Mi and Guohui Liu

    Citation: Journal of Nanobiotechnology 2020 18:66

    Content type: Research

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  20. Nanoparticle based gene delivery systems holds great promise. Superparamagnetic iron oxide nanoparticles (SPIONs) are being heavily investigated due to good biocompatibility and added diagnostic potential, ren...

    Authors: Ozlem Unal, Yunus Akkoc, Muhammed Kocak, Esra Nalbat, Asiye Isin Dogan-Ekici, Havva Yagci Acar and Devrim Gozuacik

    Citation: Journal of Nanobiotechnology 2020 18:65

    Content type: Research

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  21. The primary strategy to repair peripheral nerve injuries is to bridge the lesions by promoting axon regeneration. Thus, the ability to direct and manipulate neuronal cell axon regeneration has been one of the ...

    Authors: Yang Wang, Binxi Li, Hao Xu, Shulin Du, Ting Liu, Jingyan Ren, Jiayi Zhang, Hao Zhang, Yi Liu and Laijin Lu

    Citation: Journal of Nanobiotechnology 2020 18:64

    Content type: Research

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  22. Helicobacter pylori (H. pylori) infect more than half of the world population, and they cause different serious diseases such as gastric carcinomas. This study aims to design a vaccine on the basis of cagW agains...

    Authors: Mohammad Chehelgerdi and Abbas Doosti

    Citation: Journal of Nanobiotechnology 2020 18:63

    Content type: Research

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  23. Nucleic acid is the main material for storing, copying, and transmitting genetic information. Gene sequencing is of great significance in DNA damage research, gene therapy, mutation analysis, bacterial infecti...

    Authors: Congli Tang, Ziyu He, Hongmei Liu, Yuyue Xu, Hao Huang, Gaojian Yang, Ziqi Xiao, Song Li, Hongna Liu, Yan Deng, Zhu Chen, Hui Chen and Nongyue He

    Citation: Journal of Nanobiotechnology 2020 18:62

    Content type: Review

    Published on:

  24. Primary intracerebral hemorrhage (ICH) is a leading cause of long-term disability and death worldwide. Drug delivery vehicles to treat ICH are less than satisfactory because of their short circulation lives, l...

    Authors: Mingxin Li, Guohao Liu, Kaixuan Wang, Lingfeng Wang, Xiang Fu, Lee Yong Lim, Wei Chen and Jingxin Mo

    Citation: Journal of Nanobiotechnology 2020 18:61

    Content type: Research

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  25. Tumor recurrence in patients after surgery severely reduces the survival rate of surgical patients. Targeting and killing recurrent tumor cells and tissues is extremely important for the cancer treatment.

    Authors: Yingxue Sun, Wenhui Zhai, Xiaojun Liu, Xiangyi Song, Xiaonan Gao, Kehua Xu and Bo Tang

    Citation: Journal of Nanobiotechnology 2020 18:60

    Content type: Research

    Published on:

  26. Infectious diseases caused by multidrug-resistant (MDR) bacteria, especially MDR Gram-negative strains, have become a global public health challenge. Multifunctional nanomaterials for controlling MDR bacterial...

    Authors: Baohua Zhao, He Wang, Wenjing Dong, Shaowen Cheng, Haisheng Li, Jianglin Tan, Junyi Zhou, Weifeng He, Lanlan Li, Jianxiang Zhang, Gaoxing Luo and Wei Qian

    Citation: Journal of Nanobiotechnology 2020 18:59

    Content type: Research

    Published on:

  27. The anti-angiogenic fusion protein RBDV-IgG1 Fc (RBDV), which comprises the receptor-binding domain of vascular endothelial growth factor-A (VEGF-A), has shown antitumour effects by reducing angiogenesis in vi...

    Authors: Shu-Yi Ho, Pin-Rong Chen, Chia-Hung Chen, Nu-Man Tsai, Yu-Hsin Lin, Chen-Si Lin, Cheng-Hsun Chuang, Xiao-Fan Huang, Yi-Lin Chan, Yen-Ku Liu, Chen-Han Chung, Shun-Long Weng and Kuang-Wen Liao

    Citation: Journal of Nanobiotechnology 2020 18:58

    Content type: Research

    Published on:

  28. Intolerable toxicity and unsatisfactory therapeutic effects are still big problems retarding the use of chemotherapy against cancer. Nano-drug delivery system promised a lot in increasing the patients’ complia...

    Authors: Ming-yue Chen, Ze-kuan Xiao, Xue-ping Lei, Jie-xia Li, Xi-yong Yu, Jian-ye Zhang, Guo-dong Ye, Yu-juan Guo, Guangquan Mo, Chu-wen Li, Yu Zhang, Ling-min Zhang, Zhi-qiang Lin and Ji-jun Fu

    Citation: Journal of Nanobiotechnology 2020 18:57

    Content type: Research

    Published on:

  29. The optimal drug delivery system should be biocompatible, biodegradable, and allow the sustained release of the drug only after it reaches the target cells. Silk, as a natural polymer, is a great candidate for...

    Authors: Kamil Kucharczyk, Anna Florczak, Tomasz Deptuch, Karolina Penderecka, Katarzyna Jastrzebska, Andrzej Mackiewicz and Hanna Dams-Kozlowska

    Citation: Journal of Nanobiotechnology 2020 18:56

    Content type: Research

    Published on:

  30. Psoriasis is a malignant skin disease characterized as keratinocyte hyperproliferation and aberrant differentiation. Our previous work reported that a bibenzyl compound, erianin, has a potent inhibitory effect...

    Authors: Canlong Mo, Lulu Lu, Danyang Liu and Kun Wei

    Citation: Journal of Nanobiotechnology 2020 18:55

    Content type: Research

    Published on:

  31. Influenza viruses (IVs) have become increasingly resistant to antiviral drugs that target neuraminidase and matrix protein 2 due to gene mutations that alter their drug-binding target protein regions. Conseque...

    Authors: Jinyoung Kim, Minjoo Yeom, Taeksu Lee, Hyun-Ouk Kim, Woonsung Na, Aram Kang, Jong-Woo Lim, Geunseon Park, Chaewon Park, Daesub Song and Seungjoo Haam

    Citation: Journal of Nanobiotechnology 2020 18:54

    Content type: Research

    Published on:

  32. Ototoxicity is one of the major side effects of platinum-based chemotherapy, especially cisplatin therapy. To date, no FDA approved agents to alleviate or prevent this ototoxicity are available. However, ototo...

    Authors: Jiayi Gu, Yuming Chen, Ling Tong, Xueling Wang, Dehong Yu and Hao Wu

    Citation: Journal of Nanobiotechnology 2020 18:53

    Content type: Research

    Published on:

    The Correction to this article has been published in Journal of Nanobiotechnology 2020 18:78

  33. Graphene oxide (GO) nanoparticles (NPs) have been widely applied in various fields, especially in biomedical applications. Extensive studies have suggested that GO can pass through the blood–brain barrier (BBB...

    Authors: Chao Zhang, Xiaoli Feng, Longwen He, Yaqing Zhang and Longquan Shao

    Citation: Journal of Nanobiotechnology 2020 18:52

    Content type: Research

    Published on:

  34. The state-of-the-art hernia meshes, used in hospitals for hernia repair, are predominantly polymeric textile-based constructs that present high mechanical strength, but lack antimicrobial properties. Consequen...

    Authors: Antonios Keirouz, Norbert Radacsi, Qun Ren, Alex Dommann, Guido Beldi, Katharina Maniura-Weber, René M. Rossi and Giuseppino Fortunato

    Citation: Journal of Nanobiotechnology 2020 18:51

    Content type: Research

    Published on:

  35. Enzalutamide (Enz) has shown limited bioavailability via oral administration. Castration-resistant prostate cancer (CRPC) is frequent among patients receiving 18–24 months of androgen deprivation therapy. The ...

    Authors: Wenjun Jiang, Jiyuan Chen, Chunai Gong, Yuanyuan Wang, Yuan Gao and Yongfang Yuan

    Citation: Journal of Nanobiotechnology 2020 18:50

    Content type: Research

    Published on:

  36. Herein, a novel phototheranostic nanocomplex that is self-assembled from bovine serum albumin (BSA) and indocyanine green (ICG) is developed for enhanced near-infrared (NIR) fluorescence imaging, which benefit...

    Authors: Feifei An, Zhao Yang, Meichen Zheng, Ting Mei, Guowei Deng, Ping Guo, Yanan Li and Ruilong Sheng

    Citation: Journal of Nanobiotechnology 2020 18:49

    Content type: Research

    Published on:

  37. Specific targeting ability and good cell penetration are two critical requirements of tumor-targeted delivery systems. In the present work, we developed a novel matrix metalloprotein-triggered, cell-penetratin...

    Authors: Fangyuan Guo, Qiafan Fu, Kang Zhou, Chenghao Jin, Wenchao Wu, Xugang Ji, Qinying Yan, Qingliang Yang, Danjun Wu, Aiqin Li and Gensheng Yang

    Citation: Journal of Nanobiotechnology 2020 18:48

    Content type: Research

    Published on:

  38. Transplantation of mesenchymal stem cells (MSCs) has been considered an effective therapeutic treatment for a variety of diseases including bone fracture. However, there are associated complications along with...

    Authors: Tao Xu, Yongjun Luo, Jiaxing Wang, Ning Zhang, Changjiang Gu, Linwei Li, Dingfei Qian, Weihua Cai, Jin Fan and Guoyong Yin

    Citation: Journal of Nanobiotechnology 2020 18:47

    Content type: Research

    Published on:

  39. Peripheral nerve injury is one common clinical disease worldwide, in which sciatic nerve is anatomically the most challenging to regenerate given its length and large cross-sectional area. For the present, aut...

    Authors: Zhiwei Fang, Xuemei Ge, Xuan Chen, Yang Xu, Wei-En Yuan and Yuanming Ouyang

    Citation: Journal of Nanobiotechnology 2020 18:46

    Content type: Research

    Published on:

  40. To effectively applied nanomaterials (NMs) in medicine, one of the top priorities is to address a better understanding of the possible sub-organ transfer, clearance routes, and potential toxicity of the NMs in...

    Authors: Xue Li, Bing Wang, Shuang Zhou, Wei Chen, Hanqing Chen, Shanshan Liang, Lingna Zheng, Hongyang Yu, Runxuan Chu, Meng Wang, Zhifang Chai and Weiyue Feng

    Citation: Journal of Nanobiotechnology 2020 18:45

    Content type: Research

    Published on:

  41. Traditional sandwich enzyme-linked immunosorbent assay (ELISA) using polyclonal and monoclonal antibodies as reagents presents several drawbacks, including limited amounts, difficulty in permanent storage, and...

    Authors: Pinpin Ji, Jiahong Zhu, Xiaoxuan Li, Wenqi Fan, Qianqian Liu, Kun Wang, Jiakai Zhao, Yani Sun, Baoyuan Liu, En-Min Zhou and Qin Zhao

    Citation: Journal of Nanobiotechnology 2020 18:44

    Content type: Research

    Published on:

  42. Metastasis causes the most breast cancer-related deaths in women. Here, we investigated the antitumor effect of solid lipid nanoparticles (SLN-DTX) when used in the treatment of metastatic breast tumors using ...

    Authors: Márcia Cristina Oliveira da Rocha, Patrícia Bento da Silva, Marina Arantes Radicchi, Bárbara Yasmin Garcia Andrade, Jaqueline Vaz de Oliveira, Tom Venus, Carolin Merker, Irina Estrela-Lopis, João Paulo Figueiró Longo and Sônia Nair Báo

    Citation: Journal of Nanobiotechnology 2020 18:43

    Content type: Research

    Published on:

  43. Identifying the precise location of cells and their migration dynamics is of utmost importance for achieving the therapeutic potential of cells after implantation into a host. Magnetic resonance imaging is a s...

    Authors: Aldo Isaac Martínez-Banderas, Antonio Aires, Sandra Plaza-García, Lorena Colás, Julián A. Moreno, Timothy Ravasi, Jasmeen S. Merzaban, Pedro Ramos-Cabrer, Aitziber L. Cortajarena and Jürgen Kosel

    Citation: Journal of Nanobiotechnology 2020 18:42

    Content type: Research

    Published on:

  44. The identification of foodborne pathogenic bacteria types plays a crucial role in food safety and public health. In consideration of long culturing times, tedious operations and the desired specific recognitio...

    Authors: Mingyuan Yin, Chuang Jing, Haijie Li, Qiliang Deng and Shuo Wang

    Citation: Journal of Nanobiotechnology 2020 18:41

    Content type: Research

    Published on:

  45. The repair of large bone defects is a great challenge in clinical practice. In this study, copper-loaded-ZIF-8 nanoparticles and poly (lactide-co-glycolide) (PLGA) were combined to fabricate porous PLGA/Cu(I)@ZIF...

    Authors: Fei Zou, Jianyuan Jiang, Feizhou Lv, Xinlei Xia and Xiaosheng Ma

    Citation: Journal of Nanobiotechnology 2020 18:39

    Content type: Research

    Published on:

  46. Macrophage polarization and reprogramming in the lung play a critical role in the initiation, development and progression of acute lung injury (ALI). Regulating the activation and differentiation of pulmonary ...

    Authors: Lu Wang, Huasheng Zhang, Liya Sun, Wei Gao, Ye Xiong, Aying Ma, Xiali Liu, Lei Shen, Qiang Li and Hong Yang

    Citation: Journal of Nanobiotechnology 2020 18:38

    Content type: Research

    Published on:

  47. Functionalized multi-walled carbon nanotubes (MWCNT) have become the focus of increased research interest, particularly in their application as tools in different areas, such as the biomedical field. Despite t...

    Authors: Sara Nahle, Hilary Cassidy, Mélanie M. Leroux, Reuben Mercier, Jaafar Ghanbaja, Zahra Doumandji, David Matallanas, Bertrand H. Rihn, Olivier Joubert and Luc Ferrari

    Citation: Journal of Nanobiotechnology 2020 18:36

    Content type: Research

    Published on:

  48. Novel methods are necessary to reduce morbidity and mortality of patients suffering from infections with Pseudomonas aeruginosa. Being the most common infectious species of the Pseudomonas genus, P. aeruginosa is...

    Authors: Leisha M. Armijo, Stephen J. Wawrzyniec, Michael Kopciuch, Yekaterina I. Brandt, Antonio C. Rivera, Nathan J. Withers, Nathaniel C. Cook, Dale L. Huber, Todd C. Monson, Hugh D. C. Smyth and Marek Osiński

    Citation: Journal of Nanobiotechnology 2020 18:35

    Content type: Research

    Published on:

  49. The polymer-based drug/gene delivery is promising for the treatment of inherent or acquire disease, because of the polymer’s structural flexibility, larger capacity for therapeutic agent, low host immunogenici...

    Authors: Mingxing Wang, Bo Wu, Jason D. Tucker, Sapana N. Shah, Peijuan Lu and Qilong Lu

    Citation: Journal of Nanobiotechnology 2020 18:34

    Content type: Research

    Published on:

  50. Gold nanoparticles (GNPs) are one of the most widely used nanomaterials in various fields. Especially, the unique chemical and physical properties make them as the promising candidates in drug target identific...

    Authors: Xiao Tu, Xiaoping Tan, Xiaozhou Qi, Aiguo Huang, Fei Ling and Gaoxue Wang

    Citation: Journal of Nanobiotechnology 2020 18:32

    Content type: Research

    Published on:

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