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  1. Ultrasound-triggered sonodynamic therapy (SDT) represents an emerging therapeutic modality for cancer treatment based on its specific feature of noninvasiveness, high tissue-penetrating depth and desirable the...

    Authors: Liqiang Zhou, Minfeng Huo, Xiaoqin Qian, Li Ding, Luodan Yu, Wei Feng, Xinwu Cui and Yu Chen

    Citation: Journal of Nanobiotechnology 2021 19:112

    Content type: Research

    Published on:

  2. Nanocarriers-derived antitumor therapeutics are often associated with issues of limited tumor penetration and dissatisfactory antitumor efficacies. Some multistage delivery systems have been constructed to add...

    Authors: Xingyu Hou, Dan Zhong, Yunkun Li, Hongli Mao, Jun Yang, Hu Zhang, Kui Luo, Qiyong Gong and Zhongwei Gu

    Citation: Journal of Nanobiotechnology 2021 19:111

    Content type: Research

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  3. Nowadays, a potent challenge in cancer treatment is considered the lack of efficacious strategy, which has not been able to significantly reduce mortality. Chemoimmunotherapy (CIT) as a promising approach in b...

    Authors: Rafieh Bagherifar, Seyed Hossein Kiaie, Zahra Hatami, Armin Ahmadi, Abdolvahid Sadeghnejad, Behzad Baradaran, Reza Jafari and Yousef Javadzadeh

    Citation: Journal of Nanobiotechnology 2021 19:110

    Content type: Review

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  4. Recently, we developed hydrophobically modified glycol chitosan (HGC) nanomicelles loaded with tacrolimus (TAC) (HGC-TAC) for the targeted renal delivery of TAC. Herein, we determined whether the administratio...

    Authors: Chang Seong Kim, Ansuja Pulickal Mathew, Arathy Vasukutty, Saji Uthaman, Soo Yeon Joo, Eun Hui Bae, Seong Kwon Ma, In-Kyu Park and Soo Wan Kim

    Citation: Journal of Nanobiotechnology 2021 19:109

    Content type: Research

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  5. The widespread use of nanomaterials (NMs) has raised concerns that exposure to them may introduce potential risks to the human body and environment. The liver is the main target organ for NMs. Hepatotoxic effe...

    Authors: Ting Sun, Yiyuan Kang, Jia Liu, Yanli Zhang, Lingling Ou, Xiangning Liu, Renfa Lai and Longquan Shao

    Citation: Journal of Nanobiotechnology 2021 19:108

    Content type: Review

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  6. Nonspecific liver uptake of nanomaterials after intravenous injection has hindered nanomedicine for clinical translation. However, nanomaterials’ propensity for liver distribution might enable their use in hep...

    Authors: Xiaobing Zhang, Jiajia Hu, Kaelyn V. Becker, Jonathan W. Engle, Dalong Ni, Weibo Cai, Dong Wu and Shuping Qu

    Citation: Journal of Nanobiotechnology 2021 19:107

    Content type: Research

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  7. Carbon dots (CDs) with multifaceted advantages have provided hope for development brand-new nanodrug for treating thorny diseases. This study developed a green and simple calcination method to prepare novel CD...

    Authors: Meiling Zhang, Jinjun Cheng, Jie Hu, Juan Luo, Yue Zhang, Fang Lu, Hui Kong, Huihua Qu and Yan Zhao

    Citation: Journal of Nanobiotechnology 2021 19:105

    Content type: Research

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  8. The ubiquitous nature of bacterial biofilms combined with the enhanced resistance towards antimicrobials has led to the development of an increasing number of strategies for biofilm eradication. Such strategie...

    Authors: Caio H. N. Barros, Dishon W. Hiebner, Stephanie Fulaz, Stefania Vitale, Laura Quinn and Eoin Casey

    Citation: Journal of Nanobiotechnology 2021 19:104

    Content type: Research

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  9. In a biological system, nanoparticles (NPs) may interact with biomolecules. Specifically, the adsorption of proteins on the nanoparticle surface may influence both the nanoparticles' and proteins' overall bio-...

    Authors: Johana Muchová, Vanessa Hearnden, Lenka Michlovská, Lucie Vištejnová, Anna Zavaďáková, Kristýna Šmerková, Silvia Kočiová, Vojtěch Adam, Pavel Kopel and Lucy Vojtová

    Citation: Journal of Nanobiotechnology 2021 19:103

    Content type: Research

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  10. The immunomodulation of the antitumor response driven by immunocheckpoint inhibitors (ICIs) such as PD-L1 (Programmed Death Ligand-1) monoclonal antibody (α-PD-L1) have shown relevant clinical outcomes in a su...

    Authors: María Merino, Teresa Lozano, Noelia Casares, Hugo Lana, Iñaki F. Troconiz, Timo L. M. ten Hagen, Grazyna Kochan, Pedro Berraondo, Sara Zalba and María J. Garrido

    Citation: Journal of Nanobiotechnology 2021 19:102

    Content type: Research

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  11. Psoriasis is a chronic autoimmune skin disease characterized by hyperproliferation of keratinocytes. Wide treatment options used to treat psoriasis is associated with various adverse effects. To overcome this ...

    Authors: Vinod Gangadevi, Sowjanya Thatikonda, Venkatesh Pooladanda, Geetanjali Devabattula and Chandraiah Godugu

    Citation: Journal of Nanobiotechnology 2021 19:101

    Content type: Research

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  12. Carvedilol, the anti-hypertensive drug, has poor bioavailability when administered orally. Ethosomes-mediated transdermal delivery is considered a potential route of administration to increase the bioavailabil...

    Authors: Padmanabha Rao Amarachinta, Garima Sharma, Noufel Samed, Ananda Kumar Chettupalli, Madhusudhan Alle and Jin-Chul Kim

    Citation: Journal of Nanobiotechnology 2021 19:100

    Content type: Research

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  13. Bacterial biofilm is the complicated clinical issues, which usually results in bacterial resistance and reduce the therapeutic efficacy of antibiotics. Although micelles have been drawn attention in treatment ...

    Authors: Xiangjun Chen, Rong Guo, Changrong Wang, Keke Li, Xinyu Jiang, Huayu He and Wei Hong

    Citation: Journal of Nanobiotechnology 2021 19:99

    Content type: Research

    Published on:

  14. Nano-Fenton reactors as novel strategy to selectively convert hydrogen peroxide (H2O2) into active hydroxyl radicals in tumor microenvironment for cancer therapy had attracted much attention. However, side effect...

    Authors: Dongdong Sun, Zekun Wang, Pu Zhang, Chenyang Yin, Jingyuan Wang, Yu Sun, Ying Chen, Weiyun Wang, Baoliang Sun and Cundong Fan

    Citation: Journal of Nanobiotechnology 2021 19:98

    Content type: Research

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  15. The development of two-dimensional (2D) monoelemental nanomaterials (Xenes) for biomedical applications has generated intensive interest over these years. In this paper, the biomedical applications using Xene-...

    Authors: Ping Gao, Yufen Xiao, YuliangWang, Leijiao Li, Wenliang Li and Wei Tao

    Citation: Journal of Nanobiotechnology 2021 19:96

    Content type: Review

    Published on:

  16. There is a great interest in the efficient intracellular delivery of Cas9-sgRNA ribonucleoprotein complex (RNP) and its possible applications for in vivo CRISPR-based gene editing. In this study, a nanoporous ...

    Authors: Pardis Rahimi Salekdeh, Leila Ma’mani, Javad Tavakkoly-Bazzaz, Hossein Mousavi, Mohammad Hossein Modarressi and Ghasem Hosseini Salekdeh

    Citation: Journal of Nanobiotechnology 2021 19:95

    Content type: Research

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  17. Periodically regenerated hair follicles provide an excellent research model for studying tissue regeneration and stem cell homeostasis. Periodic activation and differentiation of hair follicle stem cells (HFSC...

    Authors: Peng Chen, Feifei Zhang, Zhexiang Fan, Tianding Shen, Bingcheng Liu, Ruosi Chen, Qian Qu, Jin Wang, Yong Miao and Zhiqi Hu

    Citation: Journal of Nanobiotechnology 2021 19:94

    Content type: Research

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  18. Metal sulfide nanomaterials (MeSNs) are a novel class of metal-containing nanomaterials composed of metal ions and sulfur compounds. During the past decade, scientists found that the MeSNs engineered by specif...

    Authors: Weidong Fei, Meng Zhang, Xiaoyu Fan, Yiqing Ye, Mengdan Zhao, Caihong Zheng, Yangyang Li and Xiaoling Zheng

    Citation: Journal of Nanobiotechnology 2021 19:93

    Content type: Review

    Published on:

  19. An amendment to this paper has been published and can be accessed via the original article.

    Authors: Yu-Wei Ge, Xiao-Liang Liu, De-gang Yu, Zhen-An Zhu, Qin-Fei Ke, Yuan-Qing Mao, Ya-Ping Guo and Jing-Wei Zhang

    Citation: Journal of Nanobiotechnology 2021 19:91

    Content type: Correction

    Published on:

    The original article was published in Journal of Nanobiotechnology 2021 19:11

  20. Despite tremendous progress has been achieved in tumor theranostic over the past decade, accurate identification and complete eradication of tumor cells remain a great challenge owing to the limitation of sing...

    Authors: Ze Wang, Guan Wang, Tingting Kang, Shuwei Liu, Lu Wang, Haoyang Zou, Yu Chong and Yi Liu

    Citation: Journal of Nanobiotechnology 2021 19:90

    Content type: Research

    Published on:

  21. Areas of hypoxia are often found in triple-negative breast cancer (TNBC), it is thus more difficult to treat than other types of breast cancer, and may require combination therapies. A new strategy that combin...

    Authors: Yi-Te Chou, Chih-Yu Lin, Jyun-Wei Wen, Ling-Chun Hung, Ying-Feng Chang, Chia-Min Yang, Li-chen Wu and Ja-an Annie Ho

    Citation: Journal of Nanobiotechnology 2021 19:89

    Content type: Research

    Published on:

  22. An amendment to this paper has been published and can be accessed via the original article.

    Authors: Yuan Xiong, Lang Chen, Chenchen Yan, Wu Zhou, Tao Yu, Yun Sun, Faqi Cao, Hang Xue, Yiqiang Hu, Dong Chen, Bobin Mi and Guohui Liu

    Citation: Journal of Nanobiotechnology 2021 19:88

    Content type: Correction

    Published on:

    The original article was published in Journal of Nanobiotechnology 2020 18:66

  23. Sonodynamic therapy (SDT) is an emerging non-invasive therapeutic technique. SDT-based cancer therapy strategies are presently underway, and it may be perceived as a promising approach to improve the efficienc...

    Authors: Jingxue Wang, Ju Huang, Weichen Zhou, Jiawen Zhao, Qi Peng, Liang Zhang, Zhigang Wang, Pan Li and Rui Li

    Citation: Journal of Nanobiotechnology 2021 19:87

    Content type: Research

    Published on:

  24. The agricultural sector is currently facing many global challenges, such as climate change, and environmental problems such as the release of pesticides and fertilizers, which will be exacerbated in the face o...

    Authors: Howra Bahrulolum, Saghi Nooraei, Nahid Javanshir, Hossein Tarrahimofrad, Vasighe Sadat Mirbagheri, Andrew J. Easton and Gholamreza Ahmadian

    Citation: Journal of Nanobiotechnology 2021 19:86

    Content type: Review

    Published on:

  25. Graphene oxide (GO), a novel carbon-based nanomaterial, has promising applications in biomedicine. However, it induces potential cytotoxic effects on the gastrointestinal (GI) tract cells, and these effects ha...

    Authors: Siliang Liu, Angao Xu, Yanfei Gao, Yue Xie, Zhipeng Liu, Meiling Sun, Hua Mao and Xinying Wang

    Citation: Journal of Nanobiotechnology 2021 19:85

    Content type: Research

    Published on:

  26. The development of nano delivery systems is rapidly emerging area of nanotechnology applications where nanomaterials (NMs) are employed to deliver therapeutic agents to specific site in a controlled manner. To...

    Authors: Priyadarshani S. Sadalage, Reshma V. Patil, Darshana V. Havaldar, Shruti S. Gavade, Ana Cláudia Santos and Kiran D. Pawar

    Citation: Journal of Nanobiotechnology 2021 19:84

    Content type: Research

    Published on:

  27. Chemokine therapy with C–C motif chemokine ligand 25 (CCL25) is currently under investigation as a promising approach to treat articular cartilage degeneration. We developed a delayed release mechanism based o...

    Authors: J. Spinnen, K. Fröhlich, N. Sinner, M. Stolk, J. Ringe, L. Shopperly, M. Sittinger, T. Dehne and M. Seifert

    Citation: Journal of Nanobiotechnology 2021 19:83

    Content type: Research

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  28. Ischemic heart disease (IHD) is the leading cause of morbidity and mortality worldwide, and imposes a serious economic load. Thus, it is crucial to perform a timely and accurate diagnosis and monitoring in the...

    Authors: Xiajing Chen, Yanan Zhang, Hui Zhang, Liang Zhang, Lingjuan Liu, Yang Cao, Haitao Ran and Jie Tian

    Citation: Journal of Nanobiotechnology 2021 19:82

    Content type: Research

    Published on:

  29. Triple-negative breast cancer (TNBC) is a kind of aggressive breast cancer with a high rate of metastasis, poor overall survival time, and a low response to targeted therapies. To improve the therapeutic effic...

    Authors: Hanyi Fang, Yongkang Gai, Sheng Wang, Qingyao Liu, Xiao Zhang, Min Ye, Jianling Tan, Yu Long, Kuanyin Wang, Yongxue Zhang and Xiaoli Lan

    Citation: Journal of Nanobiotechnology 2021 19:81

    Content type: Research

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  30. The recently developed biomimetic strategy is one of the mostly effective strategies for improving the theranostic efficacy of diverse nanomedicines, because nanoparticles coated with cell membranes can disgui...

    Authors: Yipengchen Yin, Yongjing Li, Sheng Wang, Ziliang Dong, Chao Liang, Jiaxin Sun, Changchun Wang, Rong Chai, Weiwei Fei, Jianping Zhang, Ming Qi, Liangzhu Feng and Qin Zhang

    Citation: Journal of Nanobiotechnology 2021 19:80

    Content type: Research

    Published on:

  31. Osteosarcoma (OS) is the most common primary malignant bone tumor occurring in children and young adults. Drug-resistant osteosarcoma often results in chemotherapy failure. Therefore, new treatments aimed at n...

    Authors: Wei-Nan Zeng, Qiu-Ping Yu, Duan Wang, Jun-Li Liu, Qing-Jun Yang, Zong-Ke Zhou and Yi-Ping Zeng

    Citation: Journal of Nanobiotechnology 2021 19:79

    Content type: Research

    Published on:

  32. Micro/nano-textured hierarchical titanium topography is more bioactive and biomimetic than smooth, micro-textured or nano-textured titanium topographies. Bone marrow mesenchymal stem cells (BMSCs) and exosomes...

    Authors: Zhengchuan Zhang, Ruogu Xu, Yang Yang, Chaoan Liang, Xiaolin Yu, Yun Liu, Tianlu Wang, Yi Yu and Feilong Deng

    Citation: Journal of Nanobiotechnology 2021 19:78

    Content type: Research

    Published on:

  33. Although many treatments for breast cancer are available, poor tumour targeting limits the effectiveness of most approaches. Consequently, it is difficult to achieve satisfactory results with monotherapies. Th...

    Authors: Pengcheng Xu, Ru Wang, Wenqian Yang, Yanyan Liu, Dongsheng He, Zixuan Ye, Daquan Chen, Yuan Ding, Jiasheng Tu and Yan Shen

    Citation: Journal of Nanobiotechnology 2021 19:77

    Content type: Research

    Published on:

  34. Hepatocellular carcinoma (HCC) is a common malignant tumor with poor prognosis. Magnetic resonance imaging (MRI) is one of the most effective imaging methods for the early diagnosis of HCC. However, the curren...

    Authors: Kai Fan, Chengying Lu, Gaofeng Shu, Xiu-Ling Lv, Enqi Qiao, Nannan Zhang, Minjiang Chen, Jingjing Song, Fazong Wu, Zhongwei Zhao, Xiaoling Xu, Min Xu, Chunmiao Chen, Weibin Yang, Jihong Sun, Yongzhong Du…

    Citation: Journal of Nanobiotechnology 2021 19:76

    Content type: Research

    Published on:

  35. Cadmium (Cd) is amongst the most toxic heavy metals that severely affects crop growth, whereas application of nanoparticles (NPs) to negate the toxic effects of heavy metals could be an effective management ap...

    Authors: Yuzhan Li, Luxin Liang, Wu Li, Umair Ashraf, Lin Ma, Xiangru Tang, Shenggang Pan, Hua Tian and Zhaowen Mo

    Citation: Journal of Nanobiotechnology 2021 19:75

    Content type: Research

    Published on:

  36. This research was to develop a special method for enriching Circulating tumor cells (CTCs) of Hepatocellular carcinoma (HCC) by Glypican-3 immunoliposomes (GPC3-IML), and to analyze the correlation between the...

    Authors: Bin Yi, Tian Wu, Nan Zhu, Yao Huang, Xiaoyu Yang, Lei Yuan, Yingjun Wu, Xiaofei Liang and Xiaoqing Jiang

    Citation: Journal of Nanobiotechnology 2021 19:74

    Content type: Research

    Published on:

  37. Blood prostate-specific antigen (PSA) levels are widely used as diagnostic biomarkers for prostate cancer. Lateral-flow immunoassay (LFIA)-based PSA detection can overcome the limitations associated with other...

    Authors: Hyung-Mo Kim, Jaehi Kim, Jaehyun An, Sungje Bock, Xuan-Hung Pham, Kim-Hung Huynh, Yoonsik Choi, Eunil Hahm, Hobeom Song, Jung-Won Kim, Won-Yeop Rho, Dae Hong Jeong, Ho-Young Lee, Sangchul Lee and Bong-Hyun Jun

    Citation: Journal of Nanobiotechnology 2021 19:73

    Content type: Research

    Published on:

  38. This review highlights current developments, challenges, and future directions for the use of invasive and noninvasive biosample-based small biosensors for early diagnosis of Alzheimer’s disease (AD) with biom...

    Authors: Hem Prakash Karki, Yeongseok Jang, Jinmu Jung and Jonghyun Oh

    Citation: Journal of Nanobiotechnology 2021 19:72

    Content type: Review

    Published on:

  39. siRNAs hold a great potential for cancer therapy, however, poor stability in body fluids and low cellular uptake limit their use in the clinic. To enhance the bioavailability of siRNAs in tumors, novel, safe, ...

    Authors: Ezgi Oner, Mustafa Kotmakci, Anne-Marie Baird, Steven G. Gray, Bilge Debelec Butuner, Emir Bozkurt, Ayse Gulten Kantarci and Stephen P. Finn

    Citation: Journal of Nanobiotechnology 2021 19:71

    Content type: Research

    Published on:

  40. Although there has been substantial progress in the research field of gene delivery, there are some challenges remaining, e.g. there are still cell types such as primary cells and suspension cells (immune cell...

    Authors: Friederike Richter, Prosper Mapfumo, Liam Martin, Jana I. Solomun, Franziska Hausig, Jochen J. Frietsch, Thomas Ernst, Stephanie Hoeppener, Johannes C. Brendel and Anja Traeger

    Citation: Journal of Nanobiotechnology 2021 19:70

    Content type: Research

    Published on:

  41. Escherichia coli K1 (E. coli K1) caused neonatal meningitis remains a problem, which rises the urgent need for an effective vaccine. Previously, we rationally designed and produced the recombinant protein OmpAVa...

    Authors: Jin Zhang, Hongwu Sun, Chen Gao, Ying Wang, Xin Cheng, Yun Yang, Qiang Gou, Langhuang Lei, Yanping Chen, Xingyong Wang, Quanming Zou and Jiang Gu

    Citation: Journal of Nanobiotechnology 2021 19:69

    Content type: Research

    Published on:

  42. It was shown that some nanomaterials may have anticancer properties, but lack of selectivity is one of challenges, let alone selective suppression of cancer growth by regulating the cellular microenvironment. ...

    Authors: Daomei Chen, Bin Li, Tao Lei, Di Na, Minfang Nie, Yepeng Yang, Congjia, Xie, Zijuan He and Jiaqiang Wang

    Citation: Journal of Nanobiotechnology 2021 19:68

    Content type: Research

    Published on:

  43. Nanoparticles assembled from food-grade calcium carbonate have attracted attention because of their biocompatibility, digestibility, particle and surface features (such as size, surface area, and partial wetta...

    Authors: Xiaoming Guo, Xiaoying Li, Leung Chan, Wei Huang and Tianfeng Chen

    Citation: Journal of Nanobiotechnology 2021 19:67

    Content type: Research

    Published on:

  44. An amendment to this paper has been published and can be accessed via the original article.

    Authors: Yang Mu, Cunyu Jia, Xu Zheng, Haipeng Zhu, Xin Zhang, Haoran Xu, Baoyuan Liu, Qin Zhao and En-Min Zhou

    Citation: Journal of Nanobiotechnology 2021 19:66

    Content type: Correction

    Published on:

    The original article was published in Journal of Nanobiotechnology 2021 19:34

  45. Human cytomegalovirus (HCMV) is a worldwide infection, causing different troublesome in immunosupressed patients and very related to Human Immunodeficiency Virus 1 (HIV-1) infection, mainly in developing count...

    Authors: I. Relaño-Rodríguez, M. S. Espinar-Buitrago, V. Martín-Cañadilla, R. Gómez-Ramirez, J. L. Jiménez and M. A. Muñoz-Fernández

    Citation: Journal of Nanobiotechnology 2021 19:65

    Content type: Research

    Published on:

  46. Owing to high genetic diversities of tumor cells and low response rate of standard chemotherapy, patients with triple negative breast cancer (TNBC) have short progression-free survivals and poor outcomes, whic...

    Authors: Qunjiao Jiang, Li Liu, Qiuying Li, Yi Cao, Dong Chen, Qishi Du, Xiaobo Yang, Dongping Huang, Renjun Pei, Xing Chen and Gang Huang

    Citation: Journal of Nanobiotechnology 2021 19:64

    Content type: Research

    Published on:

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