Articles

Persistent luminescence nanoparticles for cancer theranostics application

Persistent luminescence nanoparticles (PLNPs) are unique optical materials that emit afterglow luminescence after ceasing excitation. They exhibit unexpected advantages for in vivo optical imaging of tumors, s...

Authors: Nian Liu, Xiao Chen, Xia Sun, Xiaolian Sun and Junpeng Shi

Autophagy blockade synergistically enhances nanosonosensitizer-enabled sonodynamic cancer nanotherapeutics

Ultrasound-triggered sonodynamic therapy (SDT) represents an emerging therapeutic modality for cancer treatment based on its specific feature of noninvasiveness, high tissue-penetrating depth and desirable the...

Authors: Liqiang Zhou, Minfeng Huo, Xiaoqin Qian, Li Ding, Luodan Yu, Wei Feng, Xinwu Cui and Yu Chen

Facile fabrication of multi-pocket nanoparticles with stepwise size transition for promoting deep penetration and tumor targeting

Nanocarriers-derived antitumor therapeutics are often associated with issues of limited tumor penetration and dissatisfactory antitumor efficacies. Some multistage delivery systems have been constructed to add...

Authors: Xingyu Hou, Dan Zhong, Yunkun Li, Hongli Mao, Jun Yang, Hu Zhang, Kui Luo, Qiyong Gong and Zhongwei Gu

Nanoparticle-mediated synergistic chemoimmunotherapy for tailoring cancer therapy: recent advances and perspectives

Nowadays, a potent challenge in cancer treatment is considered the lack of efficacious strategy, which has not been able to significantly reduce mortality. Chemoimmunotherapy (CIT) as a promising approach in b...

Authors: Rafieh Bagherifar, Seyed Hossein Kiaie, Zahra Hatami, Armin Ahmadi, Abdolvahid Sadeghnejad, Behzad Baradaran, Reza Jafari and Yousef Javadzadeh

Glycol chitosan-based tacrolimus-loaded nanomicelle therapy ameliorates lupus nephritis

Recently, we developed hydrophobically modified glycol chitosan (HGC) nanomicelles loaded with tacrolimus (TAC) (HGC-TAC) for the targeted renal delivery of TAC. Herein, we determined whether the administratio...

Authors: Chang Seong Kim, Ansuja Pulickal Mathew, Arathy Vasukutty, Saji Uthaman, Soo Yeon Joo, Eun Hui Bae, Seong Kwon Ma, In-Kyu Park and Soo Wan Kim

Nanomaterials and hepatic disease: toxicokinetics, disease types, intrinsic mechanisms, liver susceptibility, and influencing factors

The widespread use of nanomaterials (NMs) has raised concerns that exposure to them may introduce potential risks to the human body and environment. The liver is the main target organ for NMs. Hepatotoxic effe...

Authors: Ting Sun, Yiyuan Kang, Jia Liu, Yanli Zhang, Lingling Ou, Xiangning Liu, Renfa Lai and Longquan Shao

Antioxidant and C5a-blocking strategy for hepatic ischemia–reperfusion injury repair

Nonspecific liver uptake of nanomaterials after intravenous injection has hindered nanomedicine for clinical translation. However, nanomaterials’ propensity for liver distribution might enable their use in hep...

Authors: Xiaobing Zhang, Jiajia Hu, Kaelyn V. Becker, Jonathan W. Engle, Dalong Ni, Weibo Cai, Dong Wu and Shuping Qu

Nanotechnology based solutions for anti-leishmanial impediments: a detailed insight

As a neglected tropical disease, Leishmaniasis is significantly instigating morbidity and mortality across the globe. Its clinical spectrum varies from ulcerative cutaneous lesions to systemic immersion causin...

Authors: Humzah Jamshaid, Fakhar ud Din and Gul Majid Khan

Green Phellodendri Chinensis Cortex-based carbon dots for ameliorating imiquimod-induced psoriasis-like inflammation in mice

Carbon dots (CDs) with multifaceted advantages have provided hope for development brand-new nanodrug for treating thorny diseases. This study developed a green and simple calcination method to prepare novel CD...

Authors: Meiling Zhang, Jinjun Cheng, Jie Hu, Juan Luo, Yue Zhang, Fang Lu, Hui Kong, Huihua Qu and Yan Zhao

Synthesis and self-assembly of curcumin-modified amphiphilic polymeric micelles with antibacterial activity

The ubiquitous nature of bacterial biofilms combined with the enhanced resistance towards antimicrobials has led to the development of an increasing number of strategies for biofilm eradication. Such strategie...

Authors: Caio H. N. Barros, Dishon W. Hiebner, Stephanie Fulaz, Stefania Vitale, Laura Quinn and Eoin Casey

Mutual influence of selenium nanoparticles and FGF2-STAB^® on biocompatible properties of collagen/chitosan 3D scaffolds: in vitro and ex ovo evaluation

In a biological system, nanoparticles (NPs) may interact with biomolecules. Specifically, the adsorption of proteins on the nanoparticle surface may influence both the nanoparticles' and proteins' overall bio-...

Authors: Johana Muchová, Vanessa Hearnden, Lenka Michlovská, Lucie Vištejnová, Anna Zavaďáková, Kristýna Šmerková, Silvia Kočiová, Vojtěch Adam, Pavel Kopel and Lucy Vojtová

Dual activity of PD-L1 targeted Doxorubicin immunoliposomes promoted an enhanced efficacy of the antitumor immune response in melanoma murine model

The immunomodulation of the antitumor response driven by immunocheckpoint inhibitors (ICIs) such as PD-L1 (Programmed Death Ligand-1) monoclonal antibody (α-PD-L1) have shown relevant clinical outcomes in a su...

Authors: María Merino, Teresa Lozano, Noelia Casares, Hugo Lana, Iñaki F. Troconiz, Timo L. M. ten Hagen, Grazyna Kochan, Pedro Berraondo, Sara Zalba and María J. Garrido

Selenium nanoparticles produce a beneficial effect in psoriasis by reducing epidermal hyperproliferation and inflammation

Psoriasis is a chronic autoimmune skin disease characterized by hyperproliferation of keratinocytes. Wide treatment options used to treat psoriasis is associated with various adverse effects. To overcome this ...

Authors: Vinod Gangadevi, Sowjanya Thatikonda, Venkatesh Pooladanda, Geetanjali Devabattula and Chandraiah Godugu

Central composite design for the development of carvedilol-loaded transdermal ethosomal hydrogel for extended and enhanced anti-hypertensive effect

Carvedilol, the anti-hypertensive drug, has poor bioavailability when administered orally. Ethosomes-mediated transdermal delivery is considered a potential route of administration to increase the bioavailabil...

Authors: Padmanabha Rao Amarachinta, Garima Sharma, Noufel Samed, Ananda Kumar Chettupalli, Madhusudhan Alle and Jin-Chul Kim

On-demand pH-sensitive surface charge-switchable polymeric micelles for targeting Pseudomonas aeruginosa biofilms development

Bacterial biofilm is the complicated clinical issues, which usually results in bacterial resistance and reduce the therapeutic efficacy of antibiotics. Although micelles have been drawn attention in treatment ...

Authors: Xiangjun Chen, Rong Guo, Changrong Wang, Keke Li, Xinyu Jiang, Huayu He and Wei Hong

Ruthenium-loaded mesoporous silica as tumor microenvironment-response nano-fenton reactors for precise cancer therapy

Nano-Fenton reactors as novel strategy to selectively convert hydrogen peroxide (H₂O₂) into active hydroxyl radicals in tumor microenvironment for cancer therapy had attracted much attention. However, side effect...

Authors: Dongdong Sun, Zekun Wang, Pu Zhang, Chenyang Yin, Jingyuan Wang, Yu Sun, Ying Chen, Weiyun Wang, Baoliang Sun and Cundong Fan

Nanotechnology: new opportunities for the development of patch‐clamps

The patch-clamp technique is one of the best approaches to investigate neural excitability. Impressive improvements towards the automation of the patch-clamp technique have been made, but obvious limitations a...

Authors: Jia Gao, Chunyang Liao, Sijin Liu, Tian Xia and Guibin Jiang

Biomedical applications of 2D monoelemental materials formed by group VA and VIA: a concise review

The development of two-dimensional (2D) monoelemental nanomaterials (Xenes) for biomedical applications has generated intensive interest over these years. In this paper, the biomedical applications using Xene-...

Authors: Ping Gao, Yufen Xiao, YuliangWang, Leijiao Li, Wenliang Li and Wei Tao

Bi-functionalized aminoguanidine-PEGylated periodic mesoporous organosilica nanoparticles: a promising nanocarrier for delivery of Cas9-sgRNA ribonucleoproteine

There is a great interest in the efficient intracellular delivery of Cas9-sgRNA ribonucleoprotein complex (RNP) and its possible applications for in vivo CRISPR-based gene editing. In this study, a nanoporous ...

Authors: Pardis Rahimi Salekdeh, Leila Ma’mani, Javad Tavakkoly-Bazzaz, Hossein Mousavi, Mohammad Hossein Modarressi and Ghasem Hosseini Salekdeh

Nanoscale microenvironment engineering for expanding human hair follicle stem cell and revealing their plasticity

Periodically regenerated hair follicles provide an excellent research model for studying tissue regeneration and stem cell homeostasis. Periodic activation and differentiation of hair follicle stem cells (HFSC...

Authors: Peng Chen, Feifei Zhang, Zhexiang Fan, Tianding Shen, Bingcheng Liu, Ruosi Chen, Qian Qu, Jin Wang, Yong Miao and Zhiqi Hu

Engineering of bioactive metal sulfide nanomaterials for cancer therapy

Metal sulfide nanomaterials (MeSNs) are a novel class of metal-containing nanomaterials composed of metal ions and sulfur compounds. During the past decade, scientists found that the MeSNs engineered by specif...

Authors: Weidong Fei, Meng Zhang, Xiaoyu Fan, Yiqing Ye, Mengdan Zhao, Caihong Zheng, Yangyang Li and Xiaoling Zheng

Ultrasound targeted microbubble destruction combined with Fe-MOF based bio-/enzyme-mimics nanoparticles for treating of cancer

Authors: Xi Xiang, Houqing Pang, Tian Ma, Fangxue Du, Ling Li, Jianbo Huang, Lang Ma and Li Qiu

Correction to: Graphene-modified CePO₄ nanorods effectively treat breast cancer-induced bone metastases and regulate macrophage polarization to improve osteo-inductive ability

An amendment to this paper has been published and can be accessed via the original article.

Authors: Yu-Wei Ge, Xiao-Liang Liu, De-gang Yu, Zhen-An Zhu, Qin-Fei Ke, Yuan-Qing Mao, Ya-Ping Guo and Jing-Wei Zhang

BiVO₄/Fe₃O₄@polydopamine superparticles for tumor multimodal imaging and synergistic therapy

Despite tremendous progress has been achieved in tumor theranostic over the past decade, accurate identification and complete eradication of tumor cells remain a great challenge owing to the limitation of sing...

Authors: Ze Wang, Guan Wang, Tingting Kang, Shuwei Liu, Lu Wang, Haoyang Zou, Yu Chong and Yi Liu

Targeting triple‐negative breast cancer with an aptamer‐functionalized nanoformulation: a synergistic treatment that combines photodynamic and bioreductive therapies

Areas of hypoxia are often found in triple-negative breast cancer (TNBC), it is thus more difficult to treat than other types of breast cancer, and may require combination therapies. A new strategy that combin...

Authors: Yi-Te Chou, Chih-Yu Lin, Jyun-Wei Wen, Ling-Chun Hung, Ying-Feng Chang, Chia-Min Yang, Li-chen Wu and Ja-an Annie Ho

Correction to: M2 Macrophagy-derived exosomal miRNA-5106 induces bone mesenchymal stem cells towards osteoblastic fate by targeting salt-inducible kinase 2 and 3

An amendment to this paper has been published and can be accessed via the original article.

Authors: Yuan Xiong, Lang Chen, Chenchen Yan, Wu Zhou, Tao Yu, Yun Sun, Faqi Cao, Hang Xue, Yiqiang Hu, Dong Chen, Bobin Mi and Guohui Liu

Hypoxia modulation by dual-drug nanoparticles for enhanced synergistic sonodynamic and starvation therapy

Sonodynamic therapy (SDT) is an emerging non-invasive therapeutic technique. SDT-based cancer therapy strategies are presently underway, and it may be perceived as a promising approach to improve the efficienc...

Authors: Jingxue Wang, Ju Huang, Weichen Zhou, Jiawen Zhao, Qi Peng, Liang Zhang, Zhigang Wang, Pan Li and Rui Li

Green synthesis of metal nanoparticles using microorganisms and their application in the agrifood sector

The agricultural sector is currently facing many global challenges, such as climate change, and environmental problems such as the release of pesticides and fertilizers, which will be exacerbated in the face o...

Authors: Howra Bahrulolum, Saghi Nooraei, Nahid Javanshir, Hossein Tarrahimofrad, Vasighe Sadat Mirbagheri, Andrew J. Easton and Gholamreza Ahmadian

Graphene oxide exacerbates dextran sodium sulfate-induced colitis via ROS/AMPK/p53 signaling to mediate apoptosis

Graphene oxide (GO), a novel carbon-based nanomaterial, has promising applications in biomedicine. However, it induces potential cytotoxic effects on the gastrointestinal (GI) tract cells, and these effects ha...

Authors: Siliang Liu, Angao Xu, Yanfei Gao, Yue Xie, Zhipeng Liu, Meiling Sun, Hua Mao and Xinying Wang

Optimally biosynthesized, PEGylated gold nanoparticles functionalized with quercetin and camptothecin enhance potential anti-inflammatory, anti-cancer and anti-angiogenic activities

The development of nano delivery systems is rapidly emerging area of nanotechnology applications where nanomaterials (NMs) are employed to deliver therapeutic agents to specific site in a controlled manner. To...

Authors: Priyadarshani S. Sadalage, Reshma V. Patil, Darshana V. Havaldar, Shruti S. Gavade, Ana Cláudia Santos and Kiran D. Pawar

Therapies with CCL25 require controlled release via microparticles to avoid strong inflammatory reactions

Chemokine therapy with C–C motif chemokine ligand 25 (CCL25) is currently under investigation as a promising approach to treat articular cartilage degeneration. We developed a delayed release mechanism based o...

Authors: J. Spinnen, K. Fröhlich, N. Sinner, M. Stolk, J. Ringe, L. Shopperly, M. Sittinger, T. Dehne and M. Seifert

A non-invasive nanoparticles for multimodal imaging of ischemic myocardium in rats

Ischemic heart disease (IHD) is the leading cause of morbidity and mortality worldwide, and imposes a serious economic load. Thus, it is crucial to perform a timely and accurate diagnosis and monitoring in the...

Authors: Xiajing Chen, Yanan Zhang, Hui Zhang, Liang Zhang, Lingjuan Liu, Yang Cao, Haitao Ran and Jie Tian

Biomimetic oxygen delivery nanoparticles for enhancing photodynamic therapy in triple-negative breast cancer

Triple-negative breast cancer (TNBC) is a kind of aggressive breast cancer with a high rate of metastasis, poor overall survival time, and a low response to targeted therapies. To improve the therapeutic effic...

Authors: Hanyi Fang, Yongkang Gai, Sheng Wang, Qingyao Liu, Xiao Zhang, Min Ye, Jianling Tan, Yu Long, Kuanyin Wang, Yongxue Zhang and Xiaoli Lan

MSCs-engineered biomimetic PMAA nanomedicines for multiple bioimaging-guided and photothermal-enhanced radiotherapy of NSCLC

The recently developed biomimetic strategy is one of the mostly effective strategies for improving the theranostic efficacy of diverse nanomedicines, because nanoparticles coated with cell membranes can disgui...

Authors: Yipengchen Yin, Yongjing Li, Sheng Wang, Ziliang Dong, Chao Liang, Jiaxin Sun, Changchun Wang, Rong Chai, Weiwei Fei, Jianping Zhang, Ming Qi, Liangzhu Feng and Qin Zhang

Mitochondria-targeting graphene oxide nanocomposites for fluorescence imaging-guided synergistic phototherapy of drug-resistant osteosarcoma

Osteosarcoma (OS) is the most common primary malignant bone tumor occurring in children and young adults. Drug-resistant osteosarcoma often results in chemotherapy failure. Therefore, new treatments aimed at n...

Authors: Wei-Nan Zeng, Qiu-Ping Yu, Duan Wang, Jun-Li Liu, Qing-Jun Yang, Zong-Ke Zhou and Yi-Ping Zeng

Micro/nano-textured hierarchical titanium topography promotes exosome biogenesis and secretion to improve osseointegration

Micro/nano-textured hierarchical titanium topography is more bioactive and biomimetic than smooth, micro-textured or nano-textured titanium topographies. Bone marrow mesenchymal stem cells (BMSCs) and exosomes...

Authors: Zhengchuan Zhang, Ruogu Xu, Yang Yang, Chaoan Liang, Xiaolin Yu, Yun Liu, Tianlu Wang, Yi Yu and Feilong Deng

A DM1-doped porous gold nanoshell system for NIR accelerated redox-responsive release and triple modal imaging guided photothermal synergistic chemotherapy

Although many treatments for breast cancer are available, poor tumour targeting limits the effectiveness of most approaches. Consequently, it is difficult to achieve satisfactory results with monotherapies. Th...

Authors: Pengcheng Xu, Ru Wang, Wenqian Yang, Yanyan Liu, Dongsheng He, Zixuan Ye, Daquan Chen, Yuan Ding, Jiasheng Tu and Yan Shen

Sialic acid-engineered mesoporous polydopamine dual loaded with ferritin gene and SPIO for achieving endogenous and exogenous synergistic T2-weighted magnetic resonance imaging of HCC

Hepatocellular carcinoma (HCC) is a common malignant tumor with poor prognosis. Magnetic resonance imaging (MRI) is one of the most effective imaging methods for the early diagnosis of HCC. However, the curren...

Authors: Kai Fan, Chengying Lu, Gaofeng Shu, Xiu-Ling Lv, Enqi Qiao, Nannan Zhang, Minjiang Chen, Jingjing Song, Fazong Wu, Zhongwei Zhao, Xiaoling Xu, Min Xu, Chunmiao Chen, Weibin Yang, Jihong Sun, Yongzhong Du…

ZnO nanoparticle-based seed priming modulates early growth and enhances physio-biochemical and metabolic profiles of fragrant rice against cadmium toxicity

Cadmium (Cd) is amongst the most toxic heavy metals that severely affects crop growth, whereas application of nanoparticles (NPs) to negate the toxic effects of heavy metals could be an effective management ap...

Authors: Yuzhan Li, Luxin Liang, Wu Li, Umair Ashraf, Lin Ma, Xiangru Tang, Shenggang Pan, Hua Tian and Zhaowen Mo

The clinical significance of CTC enrichment by GPC3-IML and its genetic analysis in hepatocellular carcinoma

This research was to develop a special method for enriching Circulating tumor cells (CTCs) of Hepatocellular carcinoma (HCC) by Glypican-3 immunoliposomes (GPC3-IML), and to analyze the correlation between the...

Authors: Bin Yi, Tian Wu, Nan Zhu, Yao Huang, Xiaoyu Yang, Lei Yuan, Yingjun Wu, Xiaofei Liang and Xiaoqing Jiang

Au–Ag assembled on silica nanoprobes for visual semiquantitative detection of prostate-specific antigen

Blood prostate-specific antigen (PSA) levels are widely used as diagnostic biomarkers for prostate cancer. Lateral-flow immunoassay (LFIA)-based PSA detection can overcome the limitations associated with other...

Authors: Hyung-Mo Kim, Jaehi Kim, Jaehyun An, Sungje Bock, Xuan-Hung Pham, Kim-Hung Huynh, Yoonsik Choi, Eunil Hahm, Hobeom Song, Jung-Won Kim, Won-Yeop Rho, Dae Hong Jeong, Ho-Young Lee, Sangchul Lee and Bong-Hyun Jun

Advances in the development paradigm of biosample‐based biosensors for early ultrasensitive detection of alzheimer’s disease

This review highlights current developments, challenges, and future directions for the use of invasive and noninvasive biosample-based small biosensors for early diagnosis of Alzheimer’s disease (AD) with biom...

Authors: Hem Prakash Karki, Yeongseok Jang, Jinmu Jung and Jonghyun Oh

Development of EphA2 siRNA-loaded lipid nanoparticles and combination with a small‐molecule histone demethylase inhibitor in prostate cancer cells and tumor spheroids

siRNAs hold a great potential for cancer therapy, however, poor stability in body fluids and low cellular uptake limit their use in the clinic. To enhance the bioavailability of siRNAs in tumors, novel, safe, ...

Authors: Ezgi Oner, Mustafa Kotmakci, Anne-Marie Baird, Steven G. Gray, Bilge Debelec Butuner, Emir Bozkurt, Ayse Gulten Kantarci and Stephen P. Finn

Improved gene delivery to K-562 leukemia cells by lipoic acid modified block copolymer micelles

Although there has been substantial progress in the research field of gene delivery, there are some challenges remaining, e.g. there are still cell types such as primary cells and suspension cells (immune cell...

Authors: Friederike Richter, Prosper Mapfumo, Liam Martin, Jana I. Solomun, Franziska Hausig, Jochen J. Frietsch, Thomas Ernst, Stephanie Hoeppener, Johannes C. Brendel and Anja Traeger

Development of a chitosan‐modified PLGA nanoparticle vaccine for protection against Escherichia coli K1 caused meningitis in mice

Escherichia coli K1 (E. coli K1) caused neonatal meningitis remains a problem, which rises the urgent need for an effective vaccine. Previously, we rationally designed and produced the recombinant protein OmpAVa...

Authors: Jin Zhang, Hongwu Sun, Chen Gao, Ying Wang, Xin Cheng, Yun Yang, Qiang Gou, Langhuang Lei, Yanping Chen, Xingyong Wang, Quanming Zou and Jiang Gu

Selective mediation of ovarian cancer SKOV3 cells death by pristine carbon quantum dots/Cu₂O composite through targeting matrix metalloproteinases, angiogenic cytokines and cytoskeleton

It was shown that some nanomaterials may have anticancer properties, but lack of selectivity is one of challenges, let alone selective suppression of cancer growth by regulating the cellular microenvironment. ...

Authors: Daomei Chen, Bin Li, Tao Lei, Di Na, Minfang Nie, Yepeng Yang, Congjia, Xie, Zijuan He and Jiaqiang Wang

Edible CaCO₃ nanoparticles stabilized Pickering emulsion as calcium‐fortified formulation

Nanoparticles assembled from food-grade calcium carbonate have attracted attention because of their biocompatibility, digestibility, particle and surface features (such as size, surface area, and partial wetta...

Authors: Xiaoming Guo, Xiaoying Li, Leung Chan, Wei Huang and Tianfeng Chen

Correction to: A nanobody-horseradish peroxidase fusion protein-based competitive ELISA for rapid detection of antibodies against porcine circovirus type 2

An amendment to this paper has been published and can be accessed via the original article.

Authors: Yang Mu, Cunyu Jia, Xu Zheng, Haipeng Zhu, Xin Zhang, Haoran Xu, Baoyuan Liu, Qin Zhao and En-Min Zhou

Nanotechnology against human cytomegalovirus in vitro: polyanionic carbosilane dendrimers as antiviral agents

Human cytomegalovirus (HCMV) is a worldwide infection, causing different troublesome in immunosupressed patients and very related to Human Immunodeficiency Virus 1 (HIV-1) infection, mainly in developing count...

Authors: I. Relaño-Rodríguez, M. S. Espinar-Buitrago, V. Martín-Cañadilla, R. Gómez-Ramirez, J. L. Jiménez and M. A. Muñoz-Fernández

NIR-laser-triggered gadolinium-doped carbon dots for magnetic resonance imaging, drug delivery and combined photothermal chemotherapy for triple negative breast cancer

Owing to high genetic diversities of tumor cells and low response rate of standard chemotherapy, patients with triple negative breast cancer (TNBC) have short progression-free survivals and poor outcomes, whic...

Authors: Qunjiao Jiang, Li Liu, Qiuying Li, Yi Cao, Dong Chen, Qishi Du, Xiaobo Yang, Dongping Huang, Renjun Pei, Xing Chen and Gang Huang