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  1. Approximately 80% of brain tumours are gliomas. Despite treatment, patient mortality remains high due to local metastasis and relapse. It has been shown that transferrin-functionalised porous silicon nanoparti...

    Authors: Youssef Abdalla, Meihua Luo, Ermei Mäkilä, Bryan W. Day, Nicolas H. Voelcker and Wing Yin Tong

    Citation: Journal of Nanobiotechnology 2021 19:60

    Content type: Research

    Published on:

  2. Virus-like particles (VLPs) are virus-derived structures made up of one or more different molecules with the ability to self-assemble, mimicking the form and size of a virus particle but lacking the genetic ma...

    Authors: Saghi Nooraei, Howra Bahrulolum, Zakieh Sadat Hoseini, Camellia Katalani, Abbas Hajizade, Andrew J. Easton and Gholamreza Ahmadian

    Citation: Journal of Nanobiotechnology 2021 19:59

    Content type: Review

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  3. The combination of an immuno-metabolic adjuvant and immune checkpoint inhibitors holds great promise for effective suppression of tumor growth and invasion. In this study, a pH-responsive co-delivery platform ...

    Authors: Chunai Gong, Xiaoyan Yu, Wei Zhang, Lu Han, Rong Wang, Yujie Wang, Shen Gao and Yongfang Yuan

    Citation: Journal of Nanobiotechnology 2021 19:58

    Content type: Research

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  4. Lung cancer is the most common type of tumour worldwide. Its relative lethality is considerably high. However, since the tumour tissues are located deep within the human body, traditional technologies, such as...

    Authors: Yanan Zhang, Abdur Rauf Khan, Xiaoye Yang, Yikang Shi, Xiaogang Zhao and Guangxi Zhai

    Citation: Journal of Nanobiotechnology 2021 19:57

    Content type: Research

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  5. Uncontrolled inflammation is a central problem for many respiratory diseases. The development of potent, targeted anti-inflammatory therapies to reduce lung inflammation and re-establish the homeostasis in the...

    Authors: Lu Wang, Yafei Rao, Xiali Liu, Liya Sun, Jiameng Gong, Huasheng Zhang, Lei Shen, Aihua Bao and Hong Yang

    Citation: Journal of Nanobiotechnology 2021 19:56

    Content type: Research

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  6. Triple negative breast cancer (TNBC) is one of the most biologically aggressive breast cancers and lacks effective treatment options, resulting in a poor prognosis. Therefore, studies aiming to explore new the...

    Authors: Chuanrong Chen, Ming Shen, Hongze Liao, Qianqian Guo, Hao Fu, Jian Yu and Yourong Duan

    Citation: Journal of Nanobiotechnology 2021 19:55

    Content type: Research

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  7. Gene and chemical therapy has become one of the rising stars in the field of molecular medicine during the last two decades. However, there are still numerous challenges in the development of efficient, target...

    Authors: Yuming Yang, Yu Han, Qiuyang Sun, Jin Cheng, Caixia Yue, Yanlei Liu, Jie Song, Weilin Jin, Xianting Ding, Jesús M. de la Fuente, Jian Ni, Xiaoqiang Wang and Daxiang Cui

    Citation: Journal of Nanobiotechnology 2021 19:54

    Content type: Research

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  8. Biogenic nanoparticles possess a capping of biomolecules derived from the organism employed in the synthesis, which contributes to their stability and biological activity. These nanoparticles have been highlig...

    Authors: Mariana Guilger-Casagrande, Taís Germano-Costa, Natália Bilesky-José, Tatiane Pasquoto-Stigliani, Lucas Carvalho, Leonardo F. Fraceto and Renata de Lima

    Citation: Journal of Nanobiotechnology 2021 19:53

    Content type: Research

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  9. Sepsis is an emergency medical condition that can lead to death and it is defined as a life-threatening organ dysfunction caused by immune dysregulation in response to an infection. It is considered the main k...

    Authors: Davide Di Bella, João P. S. Ferreira, Renee de Nazare O. Silva, Cinthya Echem, Aline Milan, Eliana H. Akamine, Maria H. Carvalho and Stephen F. Rodrigues

    Citation: Journal of Nanobiotechnology 2021 19:52

    Content type: Research

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  10. Programmable nano-bio interfaces driven by tuneable vertically configured nanostructures have recently emerged as a powerful tool for cellular manipulations and interrogations. Such interfaces have strong pote...

    Authors: Roey Elnathan, Andrew W. Holle, Jennifer Young, Marina A. George, Omri Heifler, Andriy Goychuk, Erwin Frey, Ralf Kemkemer, Joachim P. Spatz, Alon Kosloff, Fernando Patolsky and Nicolas H. Voelcker

    Citation: Journal of Nanobiotechnology 2021 19:51

    Content type: Short Communication

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  11. Sialyl-Lewis X/L-selectin high affinity binding interactions between transmembrane O-glycosylated mucins proteins and the embryo have been implicated in implantation processes within the human reproductive sys...

    Authors: Lewis W. Francis, Seydou N. Yao, Lydia C. Powell, Sean Griffiths, Alexander Berquand, Thomas Piasecki, William Howe, Andrea S. Gazze, Mary C. Farach-Carson, Pamela Constantinou, Daniel Carson, Lavinia Margarit, Deya Gonzalez and R. Steven Conlan

    Citation: Journal of Nanobiotechnology 2021 19:50

    Content type: Research

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  12. Nanomaterials in plant protection promise many benefits over conventional pesticide products. Nano-enabled pesticides may alter the functionality or risk profile of active ingredients. Cationic nanochitin whis...

    Authors: Zhenya Li, Hezhong Wang, Shiheng An and Xinming Yin

    Citation: Journal of Nanobiotechnology 2021 19:49

    Content type: Research

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  13. Bacteremia-induced sepsis is a leading cause of mortality in intensive care units. To control a bacterial infection, an immune response is required, but this response might contribute to organ failure. Kidneys...

    Authors: Chia-Chih Liao, Huang-Ping Yu, Shih-Chun Yang, Ahmed Alalaiwe, You-Shan Dai, Fu-Chao Liu and Jia-You Fang

    Citation: Journal of Nanobiotechnology 2021 19:48

    Content type: Research

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  14. Protein tyrosine kinase 7 (PTK 7) is a membrane receptor, which can be found in various kinds of cancers. In view of this, detection of PTK 7 in the peripheral circulation would be an effective way for the ear...

    Authors: Yunsu Ma, Yuan Wang, Yongjie Liu, Lujia Shi and Dongzhi Yang

    Citation: Journal of Nanobiotechnology 2021 19:47

    Content type: Research

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  15. Streptococcal infections are associated with life-threatening pneumonia and sepsis. The rise in antibiotic resistance calls for novel approaches to treat bacterial diseases. Anti-virulence strategies promote a...

    Authors: Hervé Besançon, Viktoriia Babiychuk, Yu Larpin, René Köffel, Dominik Schittny, Lara Brockhus, Lucy J. Hathaway, Parham Sendi, Annette Draeger and Eduard Babiychuk

    Citation: Journal of Nanobiotechnology 2021 19:46

    Content type: Research

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  16. The cellular response to nanoparticles (NPs) for the mechanical clue and biochemical changes are unexplored. Here, we provide the comprehensive analysis of the Chinese Hamster Ovary (CHO-K1) cell line to study...

    Authors: Karmveer Yadav, Syed Azmal Ali, Ashok Kumar Mohanty, Eshwarmoorthy Muthusamy, Kesavan Subaharan and Gautam Kaul

    Citation: Journal of Nanobiotechnology 2021 19:45

    Content type: Research

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  17. Gene silencing using siRNA can be a new potent strategy to treat many incurable diseases at the genetic level, including cancer and viral infections. Treatments using siRNA essentially requires an efficient an...

    Authors: Yeong Chae Ryu, Kyung Ah Kim, Byoung Choul Kim, Hui-Min David Wang and Byeong Hee Hwang

    Citation: Journal of Nanobiotechnology 2021 19:44

    Content type: Research

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  18. A low pH environment is created due to the production of acids by oral biofilms that further leads to the dissolution of hydroxyapatite crystal in the tooth structure significantly altering the equilibrium. Al...

    Authors: Zohaib Akram, Sultan Aati, Hein Ngo and Amr Fawzy

    Citation: Journal of Nanobiotechnology 2021 19:43

    Content type: Research

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  19. Although immunotherapy has revolutionized treatment strategies for some types of cancers, most patients failed to respond or obtain long-term benefit. Tumor-infiltrating CD8+ T lymphocytes are closely related to ...

    Authors: Haitao Zhao, Chao Wang, Yanling Yang, Yan Sun, Weijun Wei, Cheng Wang, Liangrong Wan, Cheng Zhu, Lianghua Li, Gang Huang and Jianjun Liu

    Citation: Journal of Nanobiotechnology 2021 19:42

    Content type: Research

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  20. Owing to strong and tunable surface plasmon resonance (SPR) effect and good biocompatibility, gold nanoparticles have been suggested to be a versatile platform for a broad range of biomedical applications. In ...

    Authors: Beilei Gong, Yuanbing Shen, Huiyan Li, Xiaojun Li, Xia Huan, Jihong Zhou, Yuqing Chen, Jian Wu and Wei Li

    Citation: Journal of Nanobiotechnology 2021 19:41

    Content type: Research

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  21. Cardiac arrest (CA) is a leading cause of death worldwide. Even after successful cardiopulmonary resuscitation (CPR), the majorities of survivals are companied with permanent myocardial and cerebral injury. Hy...

    Authors: Xiaotian Sun, Yiqing Wang, Shuyan Wen, Kai Huang, Jiechun Huang, Xianglin Chu, Fangrui Wang and Liewen Pang

    Citation: Journal of Nanobiotechnology 2021 19:40

    Content type: Research

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  22. A limitation of current anticancer nanocarriers is the contradiction between multiple functions and favorable biocompatibility. Thus, we aimed to develop a compatible drug delivery system loaded with paclitaxe...

    Authors: Mingfang Wu, Chen Zhong, Qian Zhang, Lu Wang, Lingling Wang, Yanjie Liu, Xiaoxue Zhang and Xiuhua Zhao

    Citation: Journal of Nanobiotechnology 2021 19:39

    Content type: Research

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  23. Increasing antibiotic resistance continues to focus on research into the discovery of novel antimicrobial agents. Due to its antimicrobial and wound healing-promoting activity, metal nanoparticles have attract...

    Authors: Reihaneh Haghniaz, Atiya Rabbani, Fereshteh Vajhadin, Taous Khan, Rozina Kousar, Abdul Rehman Khan, Hossein Montazerian, Javed Iqbal, Alberto Libanori, Han-Jun Kim and Fazli Wahid

    Citation: Journal of Nanobiotechnology 2021 19:38

    Content type: Research

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  24. The aim to develop a highly stable near-infrared (NIR) photoinduced tumor therapy agent stems from its considerable potential for biological application. Due to its long wavelength, biological imaging exhibits...

    Authors: Yunjian Xu, Shiqi Wang, Zhenjiang Chen, Rui Hu, Shaoqiang Li, Yihua Zhao, Liwei Liu and Junle Qu

    Citation: Journal of Nanobiotechnology 2021 19:37

    Content type: Research

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  25. Owing to the hypoxia status of the tumor, the reactive oxygen species (ROS) production during photodynamic therapy (PDT) of the tumor is less efficient. Herein, a facile method which involves the synthesis of ...

    Authors: Jiayan Zhao, Hang Wu, Jiulong Zhao, Yichen Yin, Zhilun Zhang, Shige Wang and Kun Lin

    Citation: Journal of Nanobiotechnology 2021 19:36

    Content type: Research

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  26. This article has been retracted. Please see the Retraction Notice for more detail: https://doi.org/10.1186/s12951-021-00780-0

    Authors: Ji‑jun Fu, Ming‑ yue Chen, Jie‑xia Li, Jun‑ hua Zhou, Sheng‑nan Xie, Ping Yuan, Bo Tang and Cheng‑ cheng Liu

    Citation: Journal of Nanobiotechnology 2021 19:35

    Content type: Retraction Note

    Published on:

    The original article was published in Journal of Nanobiotechnology 2018 16:83

  27. The widespread popularity of porcine circovirus type 2(PCV2) has seriously affected the healthy development of the pig industry and caused huge economic losses worldwide. A rapid and reliable method is require...

    Authors: Yang Mu, Cunyu Jia, Xu Zheng, Haipeng Zhu, Xin Zhang, Haoran Xu, Baoyuan Liu, Qin Zhao and En-Min Zhou

    Citation: Journal of Nanobiotechnology 2021 19:34

    Content type: Research

    Published on:

  28. The outbreak and pandemic of coronavirus SARS-CoV-2 caused significant threaten to global public health and economic consequences. It is extremely urgent that global people must take actions to develop safe an...

    Authors: Qizhong Lu, Zongliang Zhang, Hexian Li, Kunhong Zhong, Qin Zhao, Zeng Wang, Zhiguo Wu, Donghui Yang, Shuang Sun, Nian Yang, Meijun Zheng, Qiang Chen, Cheng Long, Wenhao Guo, Hui Yang, Chunlai Nie…

    Citation: Journal of Nanobiotechnology 2021 19:33

    Content type: Research

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  29. The use of drug nanocarriers to encapsulate drugs for oral administration may become an important strategy in addressing the challenging oral absorption of some drugs. In this study—with the premise of control...

    Authors: Shiqi Guo, Yanzi Liang, Lanze Liu, Miaomiao Yin, Aiping Wang, Kaoxiang Sun, Youxin Li and Yanan Shi

    Citation: Journal of Nanobiotechnology 2021 19:32

    Content type: Research

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  30. Effective methods to deliver therapeutic genes to solid tumors and improve their bioavailability are the main challenges of current medical research on gene therapy. The development of efficient non-viral gene...

    Authors: Kai Wang, Fusheng Shang, Dagui Chen, Tieliu Cao, Xiaowei Wang, Jianpeng Jiao, Shengli He and Xiaofei Liang

    Citation: Journal of Nanobiotechnology 2021 19:31

    Content type: Research

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  31. The advances in products based on nanotechnology have directed extensive research on low-cost, biologically compatible, and easily degradable materials.

    Authors: Gitishree Das, Han-Seung Shin, Estefânia V. Ramos Campos, Leonardo Fernandes Fraceto, Maria del Pilar Rodriguez-Torres, Kelli Cristina Freitas Mariano, Daniele Ribeiro de Araujo, Fabián Fernández-Luqueño, Renato Grillo and Jayanta Kumar Patra

    Citation: Journal of Nanobiotechnology 2021 19:30

    Content type: Review

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  32. Glioblastoma (GBM) is the most invasive primary intracranial tumor, and its effective treatment is one of the most daunting challenges in oncology. The blood–brain barrier (BBB) is the main obstacle that preve...

    Authors: Chen He, Zhiyuan Zhang, Yinan Ding, Kangli Xue, Xihui Wang, Rui Yang, Yanli An, Dongfang Liu, Chunmei Hu and Qiusha Tang

    Citation: Journal of Nanobiotechnology 2021 19:29

    Content type: Research

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  33. Spinal Cord injury (SCI) is a kind of severe traumatic disease. The inflammatory response is a significant feature after SCI. Tetramethylpyrazine (TMP), a perennial herb of umbelliferae, is an alkaloid extract...

    Authors: Yan Lin, Yujie Wan, Xingjie Du, Jian Li, Jun Wei, Ting Li, Chunhong Li, Zhongbing Liu, Meiling Zhou and Zhirong Zhong

    Citation: Journal of Nanobiotechnology 2021 19:28

    Content type: Research

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  34. Magnetic nanoparticles such as magnetosomes modified with antibodies allow a high probability of their interaction with targets of interest. Magnetosomes biomineralized by magnetotactic bacteria are in homogen...

    Authors: Sha Wu, Fengfei Ma, Jinxin He, Qing X. Li, Bruce D. Hammock, Jiesheng Tian and Ting Xu

    Citation: Journal of Nanobiotechnology 2021 19:27

    Content type: Research

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  35. With the rapid advancement and progress of nanotechnology, nanomaterials with enzyme-like catalytic activity have fascinated the remarkable attention of researchers, due to their low cost, high operational sta...

    Authors: Negar Alizadeh and Abdollah Salimi

    Citation: Journal of Nanobiotechnology 2021 19:26

    Content type: Review

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  36. Virus-like particle (VLP) vaccines have recently emerged as a safe and effective alternative to conventional vaccine technologies. The strong immunogenic effects of VLPs can be harnessed for making vaccines ag...

    Authors: Vili Lampinen, Suvi Heinimäki, Olli H. Laitinen, Marko Pesu, Minna M. Hankaniemi, Vesna Blazevic and Vesa P. Hytönen

    Citation: Journal of Nanobiotechnology 2021 19:25

    Content type: Research

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  37. Toxicological evaluation of engineered nanomaterials (ENMs) is essential for occupational health and safety, particularly where bulk manufactured ENMs such as few-layer graphene (FLG) are concerned. Additional...

    Authors: Michael J. Burgum, Martin J. D. Clift, Stephen J. Evans, Nicole Hondow, Afshin Tarat, Gareth J. Jenkins and Shareen H. Doak

    Citation: Journal of Nanobiotechnology 2021 19:24

    Content type: Research

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  38. Three-dimensional photopolymerization techniques such as multiphoton polymerization lithography (MPL) and stimulated emission depletion (STED) lithography are powerful tools for fabricating structures in the s...

    Authors: Bianca Buchegger, Alexander Tanzer, Sandra Posch, Christian Gabriel, Thomas A. Klar and Jaroslaw Jacak

    Citation: Journal of Nanobiotechnology 2021 19:23

    Content type: Short Communication

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  39. Breast cancer (BC) is the most frequently diagnosed cancer and the leading cause of cancer-associated deaths in women. Recent studies have indicated that microRNA (miRNA) regulation in genomic instability (GI)...

    Authors: Siqi Bao, Ting Hu, Jiaqi Liu, Jianzhong Su, Jie Sun, Yue Ming, Jiaxin Li, Nan Wu, Hongyan Chen and Meng Zhou

    Citation: Journal of Nanobiotechnology 2021 19:22

    Content type: Research

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  40. Nanoparticles are being increasingly used in biomedical applications owing to their unique physical and chemical properties and small size. However, their biophysical assessment and evaluation of side-effects ...

    Authors: Tae Hwan Shin, Abdurazak Aman Ketebo, Da Yeon Lee, Seungah Lee, Seong Ho Kang, Shaherin Basith, Balachandran Manavalan, Do Hyeon Kwon, Sungsu Park and Gwang Lee

    Citation: Journal of Nanobiotechnology 2021 19:21

    Content type: Research

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  41. Accumulating evidence shows that mesenchymal stem cell-derived extracellular vesicles (EVs) hold great promise to promote hair growth. However, large-scale production of EVs is still a challenge. Recently, exo...

    Authors: Lei Cao, Tian Tian, Yuanbo Huang, Shiqin Tao, Xiaohong Zhu, Mifang Yang, Jing Gu, Guangdong Feng, Yinni Ma, Rushan Xia, Wenrong Xu and Lei Wang

    Citation: Journal of Nanobiotechnology 2021 19:20

    Content type: Research

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  42. Incidence of pulmonary aspergillosis is rising worldwide, owing to an increased population of immunocompromised patients. Notable potential of the pulmonary route has been witnessed in antifungal delivery due ...

    Authors: Ranjot Kaur, Sarah R. Dennison, Andrea J. Burrow, Shivaprakash M. Rudramurthy, Rajan Swami, Varun Gorki, O. P. Katare, Anupama Kaushik, Bhupinder Singh and Kamalinder K. Singh

    Citation: Journal of Nanobiotechnology 2021 19:19

    Content type: Research

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  43. The combination therapy which has been proposed as the strategy for the cancer treatment could achieve a synergistic effect for cancer therapies and reduce the dosage of the applied drugs. On account of the th...

    Authors: Fatemeh Abedi, Soodabeh Davaran, Malak Hekmati, Abolfazl Akbarzadeh, Behzad Baradaran and Sevil Vaghefi Moghaddam

    Citation: Journal of Nanobiotechnology 2021 19:18

    Content type: Research

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  44. Chemotherapy and gene therapy are used in clinical practice for the treatment of castration-resistant prostate cancer. However, the poor efficiency of drug delivery and serious systemic side effects remain an ...

    Authors: Yiran Zhang, Yanming Wang, Li Meng, Qingqing Huang, Yueqi Zhu, Wenguo Cui, Yingsheng Cheng and Ranlu Liu

    Citation: Journal of Nanobiotechnology 2021 19:17

    Content type: Research

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  45. Tumor-targeted nanoparticles hold great promise as new tools for therapy of liquid cancers. Furthermore, the therapeutic efficacy of nanoparticles can be improved by enhancing the cancer cellular internalization.

    Authors: Kai-Wen Ho, I.-J.u Chen, Yi-An Cheng, Tzu-Yi Liao, En-Shuo Liu, Huei-Jen Chen, Yun-Chi Lu, Yu-Cheng Su, Steve R. Roffler, Bo-Cheng Huang, Hui-Ju Liu, Ming-Yii Huang, Chiao-Yun Chen and Tian-Lu Cheng

    Citation: Journal of Nanobiotechnology 2021 19:16

    Content type: Research

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  46. There is a strong need for non-invasive and patient-friendly delivery systems of protein drugs for long-term therapy. However, oral delivery of protein drugs is a big challenge due to many barriers including i...

    Authors: Jae Geun Song, Sang Hoon Lee and Hyo-Kyung Han

    Citation: Journal of Nanobiotechnology 2021 19:15

    Content type: Research

    Published on:

  47. Nano-drug delivery systems show considerable promise for effective cancer therapy. Polymeric micelles have attracted extensive attention as practical nanocarriers for target drug delivery and controlled drug d...

    Authors: Changzhen Sun, Ji Lu, Jun Wang, Ping Hao, Chunhong Li, Lu Qi, Lin Yang, Bin He, Zhirong Zhong and Na Hao

    Citation: Journal of Nanobiotechnology 2021 19:14

    Content type: Research

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  48. To date, triple-negative breast cancer (TNBC) treatment options are limited because of the loss of target receptors and, as a result, are only managed with chemotherapy. What is worse is that TNBC is frequentl...

    Authors: Long Zhang, Chaofeng Mu, Tinghong Zhang, Dejun Yang, Chenou Wang, Qiong Chen, Lin Tang, Luhui Fan, Cong Liu, Jianliang Shen and Huaqiong Li

    Citation: Journal of Nanobiotechnology 2021 19:13

    Content type: Research

    Published on:

  49. After the golden age of antibiotic discovery, bacterial infections still represent a major challenge for public health worldwide. The biofilm mode of growth is mostly responsible for chronic infections that cu...

    Authors: David Da Costa, Chloé Exbrayat-Héritier, Basile Rambaud, Simon Megy, Raphaël Terreux, Bernard Verrier and Charlotte Primard

    Citation: Journal of Nanobiotechnology 2021 19:12

    Content type: Research

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  50. Advantages of polymeric nanoparticles as drug delivery systems include controlled release, enhanced drug stability and bioavailability, and specific tissue targeting. Nanoparticle properties such as hydrophobi...

    Authors: Sean Swetledge, Jangwook P. Jung, Renee Carter and Cristina Sabliov

    Citation: Journal of Nanobiotechnology 2021 19:10

    Content type: Review

    Published on:

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