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  1. DNA methylation detection is indispensable for the diagnosis and prognosis of various diseases including malignancies. Hence, it is crucial to develop a simple, sensitive, and specific detection strategy.

    Authors: Shu Zhang, Jian Huang, Jingrun Lu, Min Liu, Yan Li, Lichao Fang, Hui Huang, Jianjun Huang, Fei Mo and Junsong Zheng

    Citation: Journal of Nanobiotechnology 2019 17:121

    Content type: Research

    Published on:

  2. Tamoxifen (Tam) is the most frequent treatment for estrogen receptor (ER) positive breast cancer. We recently showed that fibronectin (FN) leads to Tam resistance and selection of breast cancer stem cells. Wit...

    Authors: María Inés Diaz Bessone, Lorena Simón-Gracia, Pablo Scodeller, María de los Angeles Ramirez, María Amparo Lago Huvelle, Galo J. A. A. Soler-Illia and Marina Simian

    Citation: Journal of Nanobiotechnology 2019 17:120

    Content type: Research

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  3. The functional preservation of the central nervous system (CNS) is based on the neuronal plasticity and survival. In this context, the neuroinflammatory state plays a key role and involves the microglial cells...

    Authors: Quentin Lemaire, Antonella Raffo-Romero, Tanina Arab, Christelle Van Camp, Francesco Drago, Stefano Forte, Jean-Pascal Gimeno, Séverine Begard, Morvane Colin, Jacopo Vizioli, Pierre-Eric Sautière, Michel Salzet and Christophe Lefebvre

    Citation: Journal of Nanobiotechnology 2019 17:119

    Content type: Research

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  4. Developing new strategies to reduce the output power of microwave (MW) ablation while keeping anti-tumor effect are highly desirable for the simultaneous achievement of effective tumor killing and avoidance of...

    Authors: Jian-ping Dou, Qiong Wu, Chang-hui Fu, Dong-yun Zhang, Jie Yu, Xian-wei Meng and Ping Liang

    Citation: Journal of Nanobiotechnology 2019 17:118

    Content type: Research

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  5. Cancer cells always develop ways to resist and evade chemotherapy. To overcome this obstacle, herein, we introduce a programmatic release drug delivery system that imparts avoiding drug efflux and nuclear tran...

    Authors: Yanyan Li, Yongxia Zhai, Wei Liu, Kaixiang Zhang, Junjie Liu, Jinjin Shi and Zhenzhong Zhang

    Citation: Journal of Nanobiotechnology 2019 17:117

    Content type: Research

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  6. Tumor cells with heterogeneity and diversity can express different markers. At present, positive separation of circulating tumor cells (CTC) taking EpCAM as the marker was used in most cases which could be one...

    Authors: Jingde Chen, Lin Chen, Shibin Du, Jing Wu, Ming Quan, Hua Yin, Yin Wu, Xuanting Ye, Xiaofei Liang and Hong Jiang

    Citation: Journal of Nanobiotechnology 2019 17:116

    Content type: Review

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  7. We designed liposomes dually functionalized with ApoE-derived peptide (mApoE) and chlorotoxin (ClTx) to improve their blood–brain barrier (BBB) crossing. Our results demonstrated the synergistic activity of Cl...

    Authors: Beatrice Formicola, Roberta Dal Magro, Carlos V. Montefusco-Pereira, Claus-Michael Lehr, Marcus Koch, Laura Russo, Gianvito Grasso, Marco A. Deriu, Andrea Danani, Sandrine Bourdoulous and Francesca Re

    Citation: Journal of Nanobiotechnology 2019 17:115

    Content type: Short Communication

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  8. The biological activity of MXenes has been studied for several years because of their potential biomedical applications; however, investigations have so far been limited to 2D titanium carbides. Although monol...

    Authors: A. Szuplewska, A. Rozmysłowska-Wojciechowska, S. Poźniak, T. Wojciechowski, M. Birowska, M. Popielski, M. Chudy, W. Ziemkowska, L. Chlubny, D. Moszczyńska, A. Olszyna, J. A. Majewski and A. M. Jastrzębska

    Citation: Journal of Nanobiotechnology 2019 17:114

    Content type: Research

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  9. Synergistic therapy of tumor is a promising way in curing cancer and in order to achieve effective tumor therapy with real-time drug release monitoring, dynamic cellular imaging and antitumor activity.

    Authors: Chen Du, Yan Liang, Qingming Ma, Qianwen Sun, Jinghui Qi, Jie Cao, Shangcong Han, Mingtao Liang, Bo Song and Yong Sun

    Citation: Journal of Nanobiotechnology 2019 17:113

    Content type: Research

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  10. Cerium oxide nanoparticles are effective scavengers of reactive oxygen species and have been proposed as a treatment for oxidative stress-related diseases. Consequently, we aimed to investigate the effect of t...

    Authors: Bernat Córdoba-Jover, Altamira Arce-Cerezo, Jordi Ribera, Montse Pauta, Denise Oró, Gregori Casals, Guillermo Fernández-Varo, Eudald Casals, Victor Puntes, Wladimiro Jiménez and Manuel Morales-Ruiz

    Citation: Journal of Nanobiotechnology 2019 17:112

    Content type: Research

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  11. Triple negative breast cancer (TNBC) has the poorest prognosis of all breast cancer subtypes and is one of the most fatal diseases for women. Combining cytotoxic chemotherapy with immunotherapy has shown great...

    Authors: Shen-Jun Yuan, Yong-Hong Xu, Chao Wang, Hui-Chao An, Hua-Zhen Xu, Ke Li, Naoki Komatsu, Li Zhao and Xiao Chen

    Citation: Journal of Nanobiotechnology 2019 17:110

    Content type: Research

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  12. Multidrug resistance (MDR) generally leads to breast cancer treatment failure. The most common mechanism of MDR is the overexpression of ATP-binding cassette (ABC) efflux transporters such as P-glycoprotein (P...

    Authors: Sipei Zhang, Nan Guo, Guoyun Wan, Tao Zhang, Chunyu Li, Yongfei Wang, Yinsong Wang and Yuanyuan Liu

    Citation: Journal of Nanobiotechnology 2019 17:109

    Content type: Research

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  13. A major bottleneck in drug delivery is the breakdown and degradation of the delivery system through the endosomal/lysosomal network of the host cell, hampering the correct delivery of the drug of interest. In ...

    Authors: Ismael Plaza-GA, Vanesa Manzaneda-González, Matic Kisovec, Víctor Almendro-Vedia, Mónica Muñoz-Úbeda, Gregor Anderluh, Andrés Guerrero-Martínez, Paolo Natale and Iván López Montero

    Citation: Journal of Nanobiotechnology 2019 17:108

    Content type: Research

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  14. New nanophotosensitizers for photothermal cancer therapy (PTT) are still sought. In this paper we propose fancy shaped, non agglomerated core/shell PtAu NRs nanoraspberries (PtAu NRs) as potential nanophotosen...

    Authors: J. Depciuch, M. Stec, B. Klebowski, J. Baran and M. Parlinska-Wojtan

    Citation: Journal of Nanobiotechnology 2019 17:107

    Content type: Research

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  15. Improving the water solubility of hydrophobic drugs, increasing their accumulation in tumor tissue and allowing their simultaneous action by different pathways are essential issues for a successful chemotherap...

    Authors: E. Villar-Alvarez, A. Cambón, A. Pardo, L. Arellano, A. V. Marcos, B. Pelaz, P. del Pino, A. Bouzas Mosquera, V. X. Mosquera, A. Almodlej, G. Prieto, S. Barbosa and P. Taboada

    Citation: Journal of Nanobiotechnology 2019 17:106

    Content type: Research

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  16. To develop a novel fluorine-18 (18F)-labeled arginine–glycine–aspartic acid (RGD)-coupled ultra-small iron oxide nanoparticle (USPIO) (hereafter, referred to as 18F-RGD@USPIO) and conduct an in-depth investigatio...

    Authors: Yanshu Wang, Huanhuan Liu, Defan Yao, Jinning Li, Shuyan Yang, Caiyuan Zhang, Weibo Chen and Dengbin Wang

    Citation: Journal of Nanobiotechnology 2019 17:105

    Content type: Research

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  17. Efficient and highly controllable antibacterial effect, as well as good biocompatibility are required for antibacterial materials to overcome multi-drug resistance in bacteria. Herein, nano graphene oxide (NGO...

    Authors: Yongxin Zhang, Hao Fu, De-E Liu, Jinxia An and Hui Gao

    Citation: Journal of Nanobiotechnology 2019 17:104

    Content type: Research

    Published on:

  18. Immunocompromised individuals and those with lung dysfunction readily acquire pulmonary bacterial infections, which may cause serious diseases and carry a heavy economic burden. Maintaining adequate antibiotic...

    Authors: Yu Wang, Qian Yuan, Wei Feng, Wendan Pu, Jun Ding, Hongjun Zhang, Xiaoyu Li, Bo Yang, Qing Dai, Lin Cheng, Jinyu Wang, Fengjun Sun and Dinglin Zhang

    Citation: Journal of Nanobiotechnology 2019 17:103

    Content type: Research

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  19. Natural extracellular matrices (ECMs) are three-dimensional (3D) and multi-scale hierarchical structure. However, coatings used as ECM-mimicking structures for osteogenesis are typically two-dimensional or sin...

    Authors: Mengfei Yu, Yu Liu, Xiaowen Yu, Jianhua Li, Wenquan Zhao, Ji’an Hu, Kui Cheng, Wenjian Weng, Bin Zhang, Huiming Wang and Lingqing Dong

    Citation: Journal of Nanobiotechnology 2019 17:102

    Content type: Research

    Published on:

  20. Diverse properties of graphenic materials have been extensively explored to determine properties that make good electrochemical nanomaterial-based biosensors. These are reviewed by critically examining the inf...

    Authors: Teddy Tite, Elena Alina Chiticaru, Jorge S. Burns and Mariana Ioniţă

    Citation: Journal of Nanobiotechnology 2019 17:101

    Content type: Review

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  21. Pesticides and fertilizers are widely used to enhance agriculture yields, although the fraction of the pesticides applied in the field that reaches the targets is less than 0.1%. Such indiscriminate use of che...

    Authors: Marcela Candido Camara, Estefânia Vangelie Ramos Campos, Renata Aparecida Monteiro, Anderson do Espirito Santo Pereira, Patrícia Luiza de Freitas Proença and Leonardo Fernandes Fraceto

    Citation: Journal of Nanobiotechnology 2019 17:100

    Content type: Review

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  22. Combined therapy has demonstrated to be an effective strategy for cancer therapy. Herein, an injectable hydrogel based on the genetically engineered polypeptide and hollow gold nanoshells (HAuNS) has been deve...

    Authors: RuiMei Jin, Jie Yang, DongHui Zhao, XiaoLin Hou, ChaoQing Li, Wei Chen, YuanDi Zhao, ZhongYuan Yin and Bo Liu

    Citation: Journal of Nanobiotechnology 2019 17:99

    Content type: Research

    Published on:

  23. The authors apologized for the unfortunate error in figure during publication of the article and they also explained that some of the solid grey graphs in Fig. 5 are intentionally based on the same data. For 8...

    Authors: Philipp Nold, Raimo Hartmann, Neus Feliu, Karsten Kantner, Mahmoud Gamal, Beatriz Pelaz, Jonas Hühn, Xing Sun, Philipp Jungebluth, Pablo del Pino, Holger Hackstein, Paolo Macchiarini, Wolfgang J. Parak and Cornelia Brendel

    Citation: Journal of Nanobiotechnology 2019 17:98

    Content type: Correction

    Published on:

    The original article was published in Journal of Nanobiotechnology 2017 15:24

  24. Porcine epidemic diarrhea virus (PEDV), which is characterized by severe watery diarrhea, vomiting, dehydration and a high mortality rate in piglets, leads to enormous economic losses to the pork industry and ...

    Authors: Zhiqian Ma, Tianyu Wang, Zhiwei Li, Xuyang Guo, Yangsheng Tian, Yang Li and Shuqi Xiao

    Citation: Journal of Nanobiotechnology 2019 17:96

    Content type: Research

    Published on:

  25. It is extremely difficult to develop targeted treatments for triple-negative breast (TNB) cancer, because these cells do not express any of the key biomarkers usually exploited for this goal.

    Authors: Shiwei Niu, Gareth R. Williams, Jianrong Wu, Junzi Wu, Xuejing Zhang, Xia Chen, Shude Li, Jianlin Jiao and Li-Min Zhu

    Citation: Journal of Nanobiotechnology 2019 17:95

    Content type: Research

    Published on:

  26. The persistence, biodistribution, and risk of integration into the host genome of any new therapeutic DNA vaccine must be established in preclinical studies. We previously developed the DNA vaccine pcDNA-CCOL2A1 ...

    Authors: Xiao Zhao, Juan Long, Fei Liang, Nan Liu, Yuying Sun and Yongzhi Xi

    Citation: Journal of Nanobiotechnology 2019 17:94

    Content type: Research

    Published on:

  27. Exosomes (Exo) hold great promise as endogenous nanocarriers that can deliver biological information between cells. However, Exo are limited in terms of their abilities to target specific recipient cell types....

    Authors: Chunai Gong, Jing Tian, Zhuo Wang, Yuan Gao, Xin Wu, Xueying Ding, Lei Qiang, Guorui Li, Zhimin Han, Yongfang Yuan and Shen Gao

    Citation: Journal of Nanobiotechnology 2019 17:93

    Content type: Research

    Published on:

  28. The selectively accumulate in tumor site and completely release drug within cancer cells great limit the therapeutic effect of nano-drug delivery system. Moreover, absence of appropriate biomarker is one of th...

    Authors: Yifan Wang, Yanqiu Zhang, Zhengxing Ru, Wei Song, Lin Chen, Hao Ma and Lizhu Sun

    Citation: Journal of Nanobiotechnology 2019 17:91

    Content type: Research

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  29. Radiopharmaceuticals have proven to be effective agents, since they can be successfully applied for both diagnostics and therapy. Effective application of relevant radionuclides in pre-clinical and clinical st...

    Authors: Oleksii O. Peltek, Albert R. Muslimov, Mikhail V. Zyuzin and Alexander S. Timin

    Citation: Journal of Nanobiotechnology 2019 17:90

    Content type: Review

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  30. The emergence of resistance to chemotherapy or target therapy, tumor metastasis, and systemic toxicity caused by available anticancer drugs hamper the successful colorectal cancer (CRC) treatment. The rise in ...

    Authors: Shu-Ting Hong, Huaching Lin, Chen-Shen Wang, Chih-Hsien Chang, Anya Maan-Yuh Lin, James Chih-Hsin Yang and Yu-Li Lo

    Citation: Journal of Nanobiotechnology 2019 17:89

    Content type: Research

    Published on:

  31. Gold nanoparticles (AuNPs) have been proposed for many applications in medicine and bioanalysis. For use in all these applications, maintaining the stability of AuNPs in solution by suppressing aggregation is ...

    Authors: Zhanwu Hou, Zhen Wang, Run Liu, Hua Li, Zhengyi Zhang, Tian Su, Jeffy Yang and Huadong Liu

    Citation: Journal of Nanobiotechnology 2019 17:88

    Content type: Research

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  32. Adoptive T cell-transfer (ATC) therapy is a highly promising cancer-treatment approach. However, in vivo-administered T cells tend to disperse, with only a small proportion reaching the tumour. To remedy this,...

    Authors: Laura Sanz-Ortega, Yadileiny Portilla, Sonia Pérez-Yagüe and Domingo F. Barber

    Citation: Journal of Nanobiotechnology 2019 17:87

    Content type: Research

    Published on:

  33. Controllable and multiple DNA release is critical in modern gene-based therapies. Current approaches require complex assistant molecules for combined release. To overcome the restrictions on the materials and ...

    Authors: Xinyi Guo, Hongxiang Zhang, Yanyan Wang, Wei Pang and Xuexin Duan

    Citation: Journal of Nanobiotechnology 2019 17:86

    Content type: Research

    Published on:

  34. Lack of effective tumor-specific delivery systems remains an unmet clinical challenge for successful translation of innovative therapies, such as, therapeutic oligonucleotides. In the past decade, exosomes hav...

    Authors: Abi J. Vázquez-Ríos, Ángela Molina-Crespo, Belén L. Bouzo, Rafael López-López, Gema Moreno-Bueno and María de la Fuente

    Citation: Journal of Nanobiotechnology 2019 17:85

    Content type: Research

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  35. Macrophages with tumor-tropic migratory properties can serve as a cellular carrier to enhance the efficacy of anti neoplastic agents. However, limited drug loading (DL) and insufficient drug release at the tum...

    Authors: Lei Qiang, Zheng Cai, Wenjun Jiang, Jiyong Liu, Zongguang Tai, Guorui Li, Chunai Gong, Shen Gao and Yuan Gao

    Citation: Journal of Nanobiotechnology 2019 17:83

    Content type: Research

    Published on:

  36. Skin damages are defined as one of most common lesions people suffer from, some of wounds are notoriously difficult to eradicate such as chronic wounds and deep burns. Existing wound therapies have been proved...

    Authors: Wei Wang, Kong-jun Lu, Chao-heng Yu, Qiao-ling Huang and Yong-Zhong Du

    Citation: Journal of Nanobiotechnology 2019 17:82

    Content type: Review

    Published on:

  37. Magnetic nanoparticles (MNPs) are characterized by unique physicochemical and biological properties that allow their employment as highly biocompatible drug carriers. Gelsolin (GSN) is a multifunctional actin-...

    Authors: Robert Bucki, Katarzyna Niemirowicz-Laskowska, Piotr Deptuła, Agnieszka Z. Wilczewska, Paweł Misiak, Bonita Durnaś, Krzysztof Fiedoruk, Ewelina Piktel, Joanna Mystkowska and Paul A. Janmey

    Citation: Journal of Nanobiotechnology 2019 17:81

    Content type: Research

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  38. The gastric cancer is the second most malignant tumor in the world. HER-2 is one of the key targets for the gastric cancer therapy. Anti-HER-2 antibodies like trastuzumab, exhibits the satisfactory therapeutic...

    Authors: Jiayu Zhang, Tiancheng Zhao, Fanglei Han, Yu Hu and Yezhou Li

    Citation: Journal of Nanobiotechnology 2019 17:80

    Content type: Research

    Published on:

  39. Protein nanocages have emerged as popular nanocarriers for either drug delivery or biotemplates for the preparation of nanomaterials. However, only three interfaces, namely exterior surface, intersubunit and i...

    Authors: Jiachen Zang, Bowen Zheng, Xiuqing Zhang, Paolo Arosio and Guanghua Zhao

    Citation: Journal of Nanobiotechnology 2019 17:79

    Content type: Research

    Published on:

  40. The design of efficient drug delivery vectors requires versatile formulations able to simultaneously direct a multitude of molecular targets and to bypass the endosomal recycling pathway of cells. Liposomal-ba...

    Authors: Diego de la Fuente-Herreruela, Ajay K. Monnappa, Mónica Muñoz-Úbeda, Aarón Morallón-Piña, Eduardo Enciso, Luis Sánchez, Fabrice Giusti, Paolo Natale and Iván López-Montero

    Citation: Journal of Nanobiotechnology 2019 17:77

    Content type: Research

    Published on:

  41. Molybdenum disulfide (MoS2) has been widely explored for biomedical applications due to its brilliant photothermal conversion ability. In this paper, we report a novel multifunctional MoS2-based drug delivery sys...

    Authors: Chen Zhang, Doudou Zhang, Jian Liu, Jie Wang, Yusheng Lu, Junxia Zheng, Bifei Li and Lee Jia

    Citation: Journal of Nanobiotechnology 2019 17:76

    Content type: Research

    Published on:

  42. To improve the outcome of cancer treatment, the combination of multiple therapy models has proved to be effective and promising. Gas therapy (GT) and chemodynamic therapy (CDT), mainly targeting the mitochondr...

    Authors: Bin Zhao, Penghe Zhao, Zhaokui Jin, Mingjian Fan, Jin Meng and Qianjun He

    Citation: Journal of Nanobiotechnology 2019 17:75

    Content type: Research

    Published on:

  43. Diabetes is one of the biggest medical challenges worldwide. The key to efficiently treat type 1 diabetes is to accurately inject insulin according to the blood glucose levels. In this study, we aimed to devel...

    Authors: Yujie Zhang, Mingxin Wu, Wubin Dai, Min Chen, Zhaoyang Guo, Xin Wang, Di Tan, Kui Shi, Longjian Xue, Sheng Liu and Yifeng Lei

    Citation: Journal of Nanobiotechnology 2019 17:74

    Content type: Research

    Published on:

  44. Magnetic nanosensors have become attractive instruments for the diagnosis and treatment of different diseases. They represent an efficient carrier system in drug delivery or in transporting contrast agents. Fo...

    Authors: Simon Doswald, Wendelin Jan Stark and Beatrice Beck-Schimmer

    Citation: Journal of Nanobiotechnology 2019 17:73

    Content type: Review

    Published on:

  45. Nano-sized vesicles, so called extracellular vesicles (EVs), from regenerative cardiac cells represent a promising new therapeutic approach to treat cardiovascular diseases. However, it is not yet sufficiently...

    Authors: Christien M. Beez, Marion Haag, Oliver Klein, Sophie Van Linthout, Michael Sittinger and Martina Seifert

    Citation: Journal of Nanobiotechnology 2019 17:72

    Content type: Research

    Published on:

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