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  1. Cancer cells and cancer stem cells (CSCs) are the major players of cancer malignancy and metastasis, but they are extremely difficult to access. Inspired by the vital role of macrophages and microvesicle-media...

    Authors: Yuqi Wang, Xiang Gong, Jie Li, Hong Wang, Xiaoxuan Xu, Yao Wu, Jiaoying Wang, Siling Wang, Yaping Li and Zhiwen Zhang

    Citation: Journal of Nanobiotechnology 2021 19:397

    Content type: Research

    Published on:

  2. A recent study has reported that patients with nonalcoholic fatty liver disease (NAFLD) are more susceptible to coronary microvascular dysfunction (CMD), which may predict major adverse cardiac events. However...

    Authors: Rui Zuo, Li-Feng Ye, Yi Huang, Zi-Qing Song, Lei Wang, Hui Zhi, Min-Yi Zhang, Jie-Yi Li, Li Zhu, Wen-Jing Xiao, Hong-Cai Shang, Yang Zhang, Rong-Rong He and Yang Chen

    Citation: Journal of Nanobiotechnology 2021 19:396

    Content type: Research

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  3. Stimulus-responsive therapy that allows precise imaging-guided therapy is limited for osteoarthritis (OA) therapy due to the selection of proper physiological markers as stimulus. Based on that the over-produc...

    Authors: Chong Shen, Ming Gao, Haimin Chen, Yanting Zhan, Qiumei Lan, Zhimin Li, Wei Xiong, Zainen Qin, Li Zheng and Jinmin Zhao

    Citation: Journal of Nanobiotechnology 2021 19:395

    Content type: Research

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  4. Poly(D, L-lactic-co-glycolic acid) (PLGA) nanoparticles have potential applications as a vaccine adjuvant and delivery system due to its unique advantages as biodegradability and biocompatibility.

    Authors: Shulan Han, Wenyan Ma, Dawei Jiang, Logan Sutherlin, Jing Zhang, Yu Lu, Nan Huo, Zhao Chen, Jonathan W. Engle, Yanping Wang, Xiaojie Xu, Lei Kang, Weibo Cai and Lianyan Wang

    Citation: Journal of Nanobiotechnology 2021 19:394

    Content type: Research

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  5. Bladder cancer (BC) is a common malignancy in the genitourinary system and the current theranostic approaches are unsatisfactory. Sensitivity and specificity of current diagnosis methods are not ideal and high...

    Authors: Yadong Xu, Cheng Luo, Jieqiong Wang, Lingwu Chen, Junxing Chen, Tianfeng Chen and Qinsong Zeng

    Citation: Journal of Nanobiotechnology 2021 19:393

    Content type: Review

    Published on:

  6. Colorectal cancer is a common malignancy occurring in the digestive system and ranks second in cancer mortality worldwide. In colorectal cancer, hydrogen sulfide (H2S) is selectively upregulated, resulting in the...

    Authors: Xiang Pan, Yuchen Qi, Zhen Du, Jian He, Sheng Yao, Wei Lu, Kefeng Ding and Min Zhou

    Citation: Journal of Nanobiotechnology 2021 19:392

    Content type: Research

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  7. Considering the threat of the COVID-19 pandemic, caused by SARS-CoV-2, there is an urgent need to develop effective treatments. At present, neutralizing antibodies and small-molecule drugs such as remdesivir, ...

    Authors: Tianchuan Zhu, Yuchen Xiao, Xiaojun Meng, Lantian Tang, Bin Li, Zhaoyan Zhao, Qingqin Tan, Hong Shan, Lei Liu and Xi Huang

    Citation: Journal of Nanobiotechnology 2021 19:391

    Content type: Research

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  8. Although lower temperature (< 45 °C) photothermal therapy (LPTT) have attracted enormous attention in cancer therapy, the therapeutic effect is still unsatisfying when applying LPTT alone. Therefore, combining...

    Authors: Hongzhi Hu, Xiangtian Deng, Qingcheng Song, Wenbo Yang, Yiran Zhang, Weijian Liu, Shangyu Wang, Zihui Liang, Xin Xing, Jian Zhu, Junzhe Zhang, Zengwu Shao, Baichuan Wang and Yingze Zhang

    Citation: Journal of Nanobiotechnology 2021 19:390

    Content type: Research

    Published on:

  9. With the in-depth exploration on cancer therapeutic nanovaccines, increasing evidence shows that the poor delivery of nanovaccines to lymphoid organs has become the culprit limiting the rapid induction of anti...

    Authors: Ting Cai, Huina Liu, Shun Zhang, Jing Hu and Lingxiao Zhang

    Citation: Journal of Nanobiotechnology 2021 19:389

    Content type: Review

    Published on:

  10. Esophageal cancer is the fifth most common cancer affecting men in China. The primary treatment options are surgery and traditional radio-chemotherapy; no effective targeted therapy exists yet. Self-assembled ...

    Authors: Xiang Li, Li Zhang, Xiamei Guo, Fei Xie, Cheng Shen, Yali Jun, Chao Luo, Longfei Liu, Xiaojuan Yu, Zhengwei Zhang, Qilong Wang, Yong Gao and Keping Xu

    Citation: Journal of Nanobiotechnology 2021 19:388

    Content type: Research

    Published on:

  11. Polydopamine (PDA), which is derived from marine mussels, has excellent potential in early diagnosis of diseases and targeted drug delivery owing to its good biocompatibility, biodegradability, and phototherma...

    Authors: Menglu Zhu, Yi Shi, Yifan Shan, Junyan Guo, Xuelong Song, Yuhua Wu, Miaolian Wu, Yan Lu, Wei Chen, Xiaoling Xu and Longguang Tang

    Citation: Journal of Nanobiotechnology 2021 19:387

    Content type: Review

    Published on:

  12. The ratio of fPSA/tPSA in the "grey zone" of tPSA with the concentration range between 4 ng/ml and 10 ng/ml is significant for diagnosis of prostate cancer, and highly efficiency quantification of the ratio of...

    Authors: Yi-Cheng Zhu, Biao Cai, Quan Jiang, Yuan Zhang, Jianjun Sha and Shaowei Xie

    Citation: Journal of Nanobiotechnology 2021 19:386

    Content type: Research

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  13. Demineralization of hard tooth tissues leads to dental caries, which cause health problems and economic burdens throughout the world. A biomimetic mineralization strategy is expected to reverse early dental ca...

    Authors: Zhe Wang, Zihuai Zhou, Jiayan Fan, Leiqing Zhang, Zhixin Zhang, Zhifang Wu, Ying Shi, Haiyan Zheng, Zhengyi Zhang, Ruikang Tang and Baiping Fu

    Citation: Journal of Nanobiotechnology 2021 19:385

    Content type: Research

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  14. Pancreatic cancer is one of the most lethal malignant tumors with a low survival rate, partly because the tumor microenvironment (TME), which consists of extracellular matrix (ECM), cancer-associated fibroblas...

    Authors: Ming Jia, Dan Zhang, Chunxiang Zhang and Chunhong Li

    Citation: Journal of Nanobiotechnology 2021 19:384

    Content type: Review

    Published on:

  15. Serious infection caused by drug-resistant gram-negative bacteria and their secreted toxins (e.g., lipopolysaccharide) is a serious threat to human health. Thus, treatment strategies that efficiently kill bacteri...

    Authors: Zaihui Peng, Xiaochun Zhang, Long Yuan, Ting Li, Yajie Chen, Hao Tian, Dandan Ma, Jun Deng, Xiaowei Qi and Xuntao Yin

    Citation: Journal of Nanobiotechnology 2021 19:383

    Content type: Research

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  16. Inflammatory osteolysis, a major complication of total joint replacement surgery, can cause prosthesis failure and necessitate revision surgery. Macrophages are key effector immune cells in inflammatory respon...

    Authors: Cheng Ding, Chuang Yang, Tao Cheng, Xingyan Wang, Qiaojie Wang, Renke He, Shang Sang, Kechao Zhu, Dongdong Xu, Jiaxing Wang, Xijian Liu and Xianlong Zhang

    Citation: Journal of Nanobiotechnology 2021 19:382

    Content type: Research

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  17. The prognosis of patients with advanced gastric cancer (GC) remains unsatisfactory owing to distant metastasis and resistance to concurrent systemic therapy. Cancer-associated fibroblasts (CAFs), as essential ...

    Authors: Sheng Zheng, Jiafeng Wang, Ning Ding, Wenwen Chen, Hongda Chen, Meng Xue, Fei Chen, Jiaojiao Ni, Zhuo Wang, Zhenghua Lin, Haiping Jiang, Xiangrui Liu and Liangjing Wang

    Citation: Journal of Nanobiotechnology 2021 19:381

    Content type: Research

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  18. Mesenchymal stem cells (MSCs) play important roles in tissue repair and regeneration, such as the induction of angiogenesis, particularly under hypoxic conditions. However, the molecular mechanisms underlying ...

    Authors: Lite Ge, Chengfeng Xun, Wenshui Li, Shengyu Jin, Zuo Liu, Yi Zhuo, Da Duan, Zhiping Hu, Ping Chen and Ming Lu

    Citation: Journal of Nanobiotechnology 2021 19:380

    Content type: Research

    Published on:

  19. Matrix metalloproteinase (MMP) 2 and 9 are the family members of proteases normally up-regulated in tumor to enhance the invasion and metastatic of tumor cells, and are associated with poor outcome of head and...

    Authors: Lin-Lin Bu, Han-Qi Wang, Yuanwei Pan, Lei Chen, Hao Wu, Xianjia Wu, Chenchen Zhao, Lang Rao, Bing Liu and Zhi-Jun Sun

    Citation: Journal of Nanobiotechnology 2021 19:379

    Content type: Research

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  20. Glioma is one of the deadliest human cancers. Although many therapeutic strategies for glioma have been explored, these strategies are seldom used in the clinic. The challenges facing the treatment of glioma n...

    Authors: Wenyan Hao, Yuexin Cui, Yueyue Fan, Mengyu Chen, Guobao Yang, Yuli Wang, Meiyan Yang, Zhiping Li, Wei Gong, Yang Yang and Chunsheng Gao

    Citation: Journal of Nanobiotechnology 2021 19:378

    Content type: Research

    Published on:

  21. As we know, radiotherapy plays an irreplaceable role in the clinical management on solid tumors. However, due to the non-specific killing effects of ionizing radiation, normal tissues damages would be almost s...

    Authors: Jiao Guo, Haiyu Yang, Ya Liu, Wei Liu, Ruiying Zhao, He Li, Wei Long, Wenqing Xu, Meili Guo and Xiaodong Zhang

    Citation: Journal of Nanobiotechnology 2021 19:377

    Content type: Research

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  22. Cytosine-phosphate-guanine (CpG) dinucleotides has been used as adjuvants for cancer immunotherapy. However, unmodified CpG are not very efficient in clinical trials. Glucose, ligand of C-type lectin receptors...

    Authors: Xiaojing Xu, Minfeng Gan, Youzhen Ge, Cheng Yi, Tianyun Feng, Mengjie Liu, Cenhao Wu, Xiang Chen, Weidong Zhang, Lixiang Zhao and Jun Zou

    Citation: Journal of Nanobiotechnology 2021 19:376

    Content type: Research

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  23. Mild-temperature photothermal therapy (mild-PTT) has emerged as a highly promising antitumor strategy by triggering immunogenic cell death (ICD) to elicit both innate and adaptive immune responses for tumor co...

    Authors: Zaigang Zhou, Ning Jiang, Jiashe Chen, Chunjuan Zheng, Yuanyuan Guo, Ruirong Ye, Ruogu Qi and Jianliang Shen

    Citation: Journal of Nanobiotechnology 2021 19:375

    Content type: Research

    Published on:

  24. Intimal hyperplasia caused by vascular injury is an important pathological process of many vascular diseases, especially occlusive vascular disease. In recent years, Nano-drug delivery system has attracted a w...

    Authors: Boyan Liu, Wenhua Yan, Li Luo, Shuai Wu, Yi Wang, Yuan Zhong, Dan Tang, Ali Maruf, Meng Yan, Kun Zhang, Xian Qin, Kai Qu, Wei Wu and Guixue Wang

    Citation: Journal of Nanobiotechnology 2021 19:374

    Content type: Research

    Published on:

  25. Uncontrollable inflammation and nerve cell apoptosis are the most destructive pathological response after spinal cord injury (SCI). So, inflammation suppression combined with neuroprotection is one of the most...

    Authors: Chuanjie Zhang, Daoyong Li, Hengshuo Hu, Zhe Wang, Jinyu An, Zhanshan Gao, Kaihua Zhang, Xifan Mei, Chao Wu and He Tian

    Citation: Journal of Nanobiotechnology 2021 19:373

    Content type: Research

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  26. Extracellular vesicles (EVs) are recognized as novel cell-free therapeutics. Non-alcoholic steatohepatitis (NASH) remains a critical health problem. Herein, we show that EVs from pan peroxisome proliferator-ac...

    Authors: Jimin Kim, Seul Ki Lee, Seon-Yeong Jeong, Hye Jin Cho, Joonghoon Park, Tae Min Kim and Soo Kim

    Citation: Journal of Nanobiotechnology 2021 19:372

    Content type: Research

    Published on:

  27. Effective amelioration of neuronal damages in the case of cerebral ischemic stroke (CIS) is essential for the protection of brain tissues and their functional recovery. However, most drugs can not penetrate th...

    Authors: Jingbo Hu, Xueying Tan, Dongwei Wang, Yixuan Li, Hongze Liang, Jiejun Peng, Fengyan Li, Quan Zhou, Peiwu Geng, Shuanghu Wang, Yue Yu and Jin Liu

    Citation: Journal of Nanobiotechnology 2021 19:371

    Content type: Research

    Published on:

  28. Nickel nanoparticles (Nano-Ni) are increasingly used in industry and biomedicine with the development of nanotechnology. However, the genotoxic and carcinogenic effects of Nano-Ni and the underlying mechanisms...

    Authors: Yiqun Mo, Yue Zhang, Yuanbao Zhang, Jiali Yuan, Luke Mo and Qunwei Zhang

    Citation: Journal of Nanobiotechnology 2021 19:370

    Content type: Research

    Published on:

  29. Fluorescence imaging as the beacon for optical navigation has wildly developed in preclinical studies due to its prominent advantages, including noninvasiveness and superior temporal resolution. However, the t...

    Authors: Zhuxin Wei, Guangxin Duan, Baoxing Huang, Shanshan Qiu, Dandan Zhou, Jianfeng Zeng, Jiabin Cui, Chunhong Hu, Ximing Wang, Ling Wen and Mingyuan Gao

    Citation: Journal of Nanobiotechnology 2021 19:369

    Content type: Research

    Published on:

  30. Humans have a limited postinjury regenerative ability. Therefore, cell-derived biomaterials have long been utilized for tissue repair. Cells with multipotent differentiation potential, such as stem cells, have...

    Authors: Yuan Ding, Yanjie Li, Zhongquan Sun, Xin Han, Yining Chen, Yao Ge, Zhengwei Mao and Weilin Wang

    Citation: Journal of Nanobiotechnology 2021 19:368

    Content type: Review

    Published on:

  31. Colon cancer is a most common malignant cancer in digestive system, and it is prone to develop resistance to the commonly used chemotherapy drugs, leading to local recurrence and metastasis. Paris saponin VII ...

    Authors: Shaobo Bai, Yang Sun, Ying Cheng, Weiliang Ye, Chenchao Jiang, Miao Liu, Qifeng Ji, Bangle Zhang, Qibing Mei, Daozhou Liu and Siyuan Zhou

    Citation: Journal of Nanobiotechnology 2021 19:367

    Content type: Research

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  32. 42 is one of the most extensively studied blood and Cerebrospinal fluid (CSF) biomarkers for the diagnosis of symptomatic and prodromal Alzheimer’s disease (AD). Because of the heterogeneity and transient natur...

    Authors: Liding Zhang, Xuewei Du, Ying Su, Shiqi Niu, Yanqing Li, Xiaohan Liang and Haiming Luo

    Citation: Journal of Nanobiotechnology 2021 19:366

    Content type: Research

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  33. Tumor phototherapy especially photodynamic therapy (PDT) or photothermal therapy (PTT), has been considered as an attractive strategy to elicit significant immunogenic cell death (ICD) at an optimal tumor rete...

    Authors: Ying Tian, Muhammad Rizwan Younis, Yuxia Tang, Xiang Liao, Gang He, Shouju Wang, Zhaogang Teng, Peng Huang, Longjiang Zhang and Guangming Lu

    Citation: Journal of Nanobiotechnology 2021 19:365

    Content type: Research

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  34. Malignant tumor is usually associated with epigenetic dysregulation, such as overexpression of histone deacetylase (HDAC), thus HDAC has emerged as a therapeutic target for cancer. Histone deacetylase inhibito...

    Authors: Huan Li, Songpei Li, Yinshan Lin, Sheng Chen, Langyu Yang, Xin Huang, Hao Wang, Xiyong Yu and Lingmin Zhang

    Citation: Journal of Nanobiotechnology 2021 19:364

    Content type: Research

    Published on:

  35. Our study aimed to explore the function of circRNA_0001805 in the pathogenesis of NAFLD and the underlying mechanism. A nanodrug system (GA-RM/GZ/PL) was constructed to overexpress circRNA_0001805 specifically...

    Authors: Jian Li, Jing Qi, Yishu Tang, Huaizheng Liu, Kefu Zhou, Zheren Dai, Lehong Yuan and Chuanzheng Sun

    Citation: Journal of Nanobiotechnology 2021 19:363

    Content type: Research

    Published on:

  36. Healing of MRSA (methicillin-resistant Staphylococcus aureus) infected deep burn wounds (MIDBW) in diabetic patients remains an obstacle but is a cutting-edge research problem in clinical science. Surgical deb...

    Authors: Shibo Xu, Linna Chang, Yanan Hu, Xingjun Zhao, Shuocheng Huang, Zhenhua Chen, Xiuli Ren and Xifan Mei

    Citation: Journal of Nanobiotechnology 2021 19:362

    Content type: Research

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  37. Hepatocellular carcinoma is insensitive to many chemotherapeutic agents. Ferroptosis is a form of programmed cell death with a Fenton reaction mechanism. It converts endogenous hydrogen peroxide into highly to...

    Authors: Qiao-Mei Zhou, Yuan-Fei Lu, Jia-Ping Zhou, Xiao-Yan Yang, Xiao-Jie Wang, Jie-Ni Yu, Yong-Zhong Du and Ri-Sheng Yu

    Citation: Journal of Nanobiotechnology 2021 19:361

    Content type: Research

    Published on:

  38. In addition to early detection, early diagnosis, and early surgery, it is of great significance to use new strategies for the treatment of hepatocellular carcinoma (HCC). Studies showed that the combination of...

    Authors: Zhe Li, Gang Yang, Lu Han, Rong Wang, Chunai Gong and Yongfang Yuan

    Citation: Journal of Nanobiotechnology 2021 19:360

    Content type: Research

    Published on:

  39. Acne is a common skin disorder that involves an infection inside the hair follicle, which is usually treated with antibiotics, resulting in unbalanced skin microbiota and microbial resistance. For this reason,...

    Authors: Camila Folle, Ana M. Marqués, Natalia Díaz-Garrido, Marta Espina, Elena Sánchez-López, Josefa Badia, Laura Baldoma, Ana Cristina Calpena and Maria Luisa García

    Citation: Journal of Nanobiotechnology 2021 19:359

    Content type: Research

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  40. Sonodynamic therapy (SDT), presenting spatial and temporal control of ROS generation triggered by ultrasound field, has attracted considerable attention in tumor treatment. However, its therapeutic efficacy is...

    Authors: Tian Zhang, Qiang Zheng, Yike Fu, Congkun Xie, Gonglin Fan, Yifan Wang, Yongjun Wu, Xiujun Cai, Gaorong Han and Xiang Li

    Citation: Journal of Nanobiotechnology 2021 19:358

    Content type: Research

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  41. Photoresponsive drug delivery can achieve spatiotemporal control of drug accumulation at desired sites. Long-wavelength light is preferable owing to its deep tissue penetration and low toxicity. One-photon upc...

    Authors: Kaiqi Long, Han Han, Weirong Kang, Wen Lv, Lang Wang, Yufeng Wang, Liang Ge and Weiping Wang

    Citation: Journal of Nanobiotechnology 2021 19:357

    Content type: Research

    Published on:

  42. Hepatocellular carcinoma (HCC) is a common malignant tumor with high rate of metastasis and recurrence. Although immune checkpoint blockade (ICB) has emerged as a promising type of immunotherapy in advanced HC...

    Authors: Jianjun Xu, Qichang Zheng, Xiang Cheng, Shaobo Hu, Chen Zhang, Xing Zhou, Ping Sun, Weimin Wang, Zhe Su, Tianhao Zou, Zifang Song, Yun Xia, Xiaoqing Yi and Yang Gao

    Citation: Journal of Nanobiotechnology 2021 19:355

    Content type: Research

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  43. Oral administration is an appealing route of delivering cancer treatments. However, the gastrointestinal tract is characterized by specific and efficient physical, chemical, and biological barriers that decrea...

    Authors: Alessandro Parodi, Polina Buzaeva, Daria Nigovora, Alexey Baldin, Dmitry Kostyushev, Vladimir Chulanov, Lyudmila V. Savvateeva and Andrey A. Zamyatnin Jr

    Citation: Journal of Nanobiotechnology 2021 19:354

    Content type: Review

    Published on:

  44. Titanium (Ti) implants are widely used in dentistry and orthopedics owing to their excellent corrosion resistance, biocompatibility, and mechanical properties, which have gained increasing attention from the v...

    Authors: Zheng Wang, Xiaojing Wang, Yingruo Wang, Yanli Zhu, Xinqiang Liu and Qihui Zhou

    Citation: Journal of Nanobiotechnology 2021 19:353

    Content type: Review

    Published on:

  45. Human adipose-derived stem cells (hADSCs) have been used in various fields of tissue engineering because of their promising therapeutic efficacy. However, the stemness of hADSCs cannot be maintained for long d...

    Authors: Yeong Hwan Kim, Gwang-Bum Im, Sung-Won Kim, Yu-Jin Kim, Taekyung Yu, Ju-Ro Lee, Soong Ho Um, Yoon Ki Joung and Suk Ho Bhang

    Citation: Journal of Nanobiotechnology 2021 19:352

    Content type: Research

    Published on:

  46. Multi-modal therapy has attracted increasing attention as it provides enhanced effectiveness and potential stimulation of the immune community. However, low accumulation at the tumor sites and quick immune cle...

    Authors: Jingjing Wang, Luyao Sun, Jie Liu, Bing Sun, Li Li and Zhi Ping Xu

    Citation: Journal of Nanobiotechnology 2021 19:351

    Content type: Research

    Published on:

  47. Nanoscale drug delivery systems have emerged as broadly applicable approach for chemo-photothermal therapy. However, these nanoscale drug delivery systems suffer from carrier-induced toxicity, uncontrolled dru...

    Authors: Mingtao Ao, Fei Yu, Yixiang Li, Mengya Zhong, Yonghe Tang, Hua Yang, Xiaojing Wu, Yifan Zhuang, Huiyun Wang, Xiaolian Sun, Xuehui Hong and Xiao Dong Chen

    Citation: Journal of Nanobiotechnology 2021 19:350

    Content type: Research

    Published on:

  48. One of the main challenges of tissue-engineered vascular prostheses is restenosis due to intimal hyperplasia. The aim of this study is to develop a material for scaffolds able to support cell growth while tole...

    Authors: Yuqing Niu, Massimiliano Galluzzi, Ming Fu, Jinhua Hu and Huimin Xia

    Citation: Journal of Nanobiotechnology 2021 19:349

    Content type: Research

    Published on:

  49. Viral infections are the most common among diseases that globally require around 60 percent of medical care. However, in the heat of the pandemic, there was a lack of medical equipment and inpatient facilities...

    Authors: Julija Dronina, Urte Samukaite-Bubniene and Arunas Ramanavicius

    Citation: Journal of Nanobiotechnology 2021 19:348

    Content type: Review

    Published on:

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