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  1. Drug therapy of osteoarthritis (OA) is limited by the short retention and lacking of stimulus-responsiveness after intra-articular (IA) injection. The weak acid microenvironment in joint provides a potential t...

    Authors: Feng Xiong, Zainen Qin, Haimin Chen, Qiumei Lan, Zetao Wang, Nihan Lan, Yuan Yang, Li Zheng, Jinmin Zhao and Dan Kai

    Citation: Journal of Nanobiotechnology 2020 18:139

    Content type: Research

    Published on:

  2. Neutrophil-based drug delivery system possesses excellent advantages in targeting at tumour because neutrophils are easily recruited by chemotactic factor in tumor microenvironment. Herein, we developed a nove...

    Authors: Bo Ye, Bao Zhao, Kun Wang, Yilong Guo, Qinguo Lu, Longpo Zheng, Ang Li and Jianou Qiao

    Citation: Journal of Nanobiotechnology 2020 18:138

    Content type: Research

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  3. An amendment to this paper has been published and can be accessed via the original article.

    Authors: Baohua Zhao, He Wang, Wenjing Dong, Shaowen Cheng, Haisheng Li, Jianglin Tan, Junyi Zhou, Weifeng He, Lanlan Li, Jianxiang Zhang, Gaoxing Luo and Wei Qian

    Citation: Journal of Nanobiotechnology 2020 18:137

    Content type: Correction

    Published on:

    The original article was published in Journal of Nanobiotechnology 2020 18:59

  5. Targeted contrast nanoparticles for breast tumor imaging facilitates early detection and improves treatment efficacy of breast cancer. This manuscript reports the development of an epidermal growth factor rece...

    Authors: Jesse S. Chen, Jingwen Chen, Somnath Bhattacharjee, Zhengyi Cao, Han Wang, Scott D. Swanson, Hong Zong, James R. Baker Jr and Su He Wang

    Citation: Journal of Nanobiotechnology 2020 18:135

    Content type: Research

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  6. The nucleus, besides its functions in the gene maintenance and regulation, plays a significant role in the cell mechanosensitivity and mechanotransduction. It is the largest cellular organelle that is often co...

    Authors: Yuri M. Efremov, Svetlana L. Kotova, Anastasia A. Akovantseva and Peter S. Timashev

    Citation: Journal of Nanobiotechnology 2020 18:134

    Content type: Research

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  7. Infliximab (IFX), a TNF-α blocking chimeric monoclonal antibody, induces clinical response and mucosal healing in patients with inflammatory bowel disease (IBD). However, systemic administration of this agent ...

    Authors: Jung Min Kim, Da Hye Kim, Hyo Jeong Park, Hyun Woo Ma, I Seul Park, Mijeong Son, So Youn Ro, Seokmann Hong, Hyo Kyung Han, Soo Jeong Lim, Seung Won Kim and Jae Hee Cheon

    Citation: Journal of Nanobiotechnology 2020 18:133

    Content type: Research

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  8. Due to increasing aging of population prevalence of age-related disorders including osteoporosis is rapidly growing. Due to health and economic impact of the disease, there is an urgent need to develop techniq...

    Authors: A. Seweryn, M. Alicka, A. Fal, K. Kornicka-Garbowska, K. Lawniczak-Jablonska, M. Ozga, P. Kuzmiuk, M. Godlewski and K. Marycz

    Citation: Journal of Nanobiotechnology 2020 18:132

    Content type: Research

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  9. Radiation therapy is a main treatment option for cancer. Due to normal tissue toxicity, radiosensitizers are commonly used to enhance RT. In particular, heavy metal or high-Z materials, such as gold nanopartic...

    Authors: Lin Bai, Fangchao Jiang, Renjie Wang, Chaebin Lee, Hui Wang, Weizhong Zhang, Wen Jiang, Dandan Li, Bin Ji, Zibo Li, Shi Gao, Jin Xie and Qingjie Ma

    Citation: Journal of Nanobiotechnology 2020 18:131

    Content type: Research

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  10. Fast point-of-care (POC) diagnostics represent an unmet medical need and include applications such as lateral flow assays (LFAs) for the diagnosis of sepsis and consequences of cytokine storms and for the trea...

    Authors: Christoph Ruppert, Lars Kaiser, Lisa Johanna Jacob, Stefan Laufer, Matthias Kohl and Hans-Peter Deigner

    Citation: Journal of Nanobiotechnology 2020 18:130

    Content type: Methodology

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  11. Liquid deposit mimicking surface aerosolization in the airway is a promising strategy for targeting bronchopulmonary tumors with reduced doses of nanoparticle (NPs). In mimicking and studying such delivery app...

    Authors: Lucie Sancey, Odile Sabido, Zhiguo He, Fabien Rossetti, Alain Guignandon, Valérie Bin, Jean-Luc Coll, Michèle Cottier, François Lux, Olivier Tillement, Samuel Constant, Christophe Mas and Delphine Boudard

    Citation: Journal of Nanobiotechnology 2020 18:129

    Content type: Research

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  12. Nanoparticles, which are exposed to biological fluids are rapidly interacting with proteins and other biomolecules forming a corona. In addition to dimension, charge and material the distinct protein corona in...

    Authors: Michael M. Gruber, Birgit Hirschmugl, Natascha Berger, Magdalena Holter, Snježana Radulović, Gerd Leitinger, Laura Liesinger, Andrea Berghold, Eva Roblegg, Ruth Birner-Gruenberger, Vesna Bjelic-Radisic and Christian Wadsack

    Citation: Journal of Nanobiotechnology 2020 18:128

    Content type: Research

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  13. The biofunctionalization of titanium implants for high osteogenic ability is a promising approach for the development of advanced implants to promote osseointegration, especially in compromised bone conditions...

    Authors: Kaimin Wu, Mengyuan Liu, Nan Li, Li Zhang, Fanhui Meng, Lingzhou Zhao, Min Liu and Yumei Zhang

    Citation: Journal of Nanobiotechnology 2020 18:127

    Content type: Research

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  14. Pancreatic adenocarcinoma (PDAC) is one of the most fatal malignancies. Surgical resection supplemented by chemotherapy remains the major therapeutic regimen, but with unavoidable resistance and systemic toxic...

    Authors: Tao Cheng, Zhiheng Zhang, Hua Shen, Ziying Jian, Junsheng Li, Yujun Chen, Yi Shen and Xinyi Dai

    Citation: Journal of Nanobiotechnology 2020 18:126

    Content type: Research

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  15. Incidents of viral outbreaks have increased at an alarming rate over the past decades. The most recent human coronavirus known as COVID-19 (SARS-CoV-2) has already spread around the world and shown R0 values from...

    Authors: Estefânia V. R. Campos, Anderson E. S. Pereira, Jhones Luiz de Oliveira, Lucas Bragança Carvalho, Mariana Guilger-Casagrande, Renata de Lima and Leonardo Fernandes Fraceto

    Citation: Journal of Nanobiotechnology 2020 18:125

    Content type: Review

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  16. Chemotherapy is a standard cancer treatment which uses anti-cancer drugs to destroy or slow the growth of cancer cells. However, chemotherapy has limited therapeutic effects in bladder cancer. One of the reaso...

    Authors: Guanchen Zhu, Kaikai Wang, Haixiang Qin, Xiaozhi Zhao, Wei Chen, Linfeng Xu, Wenmin Cao and Hongqian Guo

    Citation: Journal of Nanobiotechnology 2020 18:124

    Content type: Research

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  17. Poor targeting and penetration of chemotherapy drugs in solid tumors, and the development of resistance to chemotherapeutic agents are currently hindering the therapy of breast cancer; meanwhile, breast cancer...

    Authors: Zhe Ma, Nan Li, Bing Zhang, YuYu Hui, Ying Zhang, Peng Lu, Jiaxin Pi and Zhidong Liu

    Citation: Journal of Nanobiotechnology 2020 18:123

    Content type: Research

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  18. Radiotherapy is an essential step during the treatment of glioblastoma multiforme (GBM), one of the most lethal malignancies. The survival in patients with GBM was improved by the current standard of care for ...

    Authors: Jinyeong Choi, Gaeun Kim, Su Bin Cho and Hyung-Jun Im

    Citation: Journal of Nanobiotechnology 2020 18:122

    Content type: Review

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  19. Combining ultrasound imaging with photoacoustic imaging provides tissue imaging with high contrast and resolution, thereby enabling rapid, direct measurements and the tracking of tumour growth and metastasis. ...

    Authors: Minmin Lan, Lianhua Zhu, Yixuan Wang, Daijia Shen, Kejing Fang, Yu Liu, Yanli Peng, Bin Qiao and Yanli Guo

    Citation: Journal of Nanobiotechnology 2020 18:121

    Content type: Research

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  20. Brain-derived neurotrophic factor (BDNF) is essential for the development and function of human neurons, therefore it is a promising target for neurodegenerative disorders treatment. Here, we studied BDNF-base...

    Authors: Maria Dąbkowska, Karolina Łuczkowska, Dorota Rogińska, Anna Sobuś, Monika Wasilewska, Zofia Ulańczyk and Bogusław Machaliński

    Citation: Journal of Nanobiotechnology 2020 18:120

    Content type: Research

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  21. A novel bioactive inorganic material containing silicon, calcium and oxygen, calcium silicate (Ca2SiO4, C2S) with a CaO-SiO2 ingredient, has been identified as a potential candidate for artificial bone. Autophagy...

    Authors: Wang Ruolan, Chen Liangjiao and Shao Longquan

    Citation: Journal of Nanobiotechnology 2020 18:119

    Content type: Research

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  22. Developing a universal strategy to improve the specificity and sensitivity of PEGylated nanoaparticles (PEG-NPs) for assisting in the diagnosis of tumors is important in multimodality imaging. Here, we develop...

    Authors: Yi-An Cheng, Tung-Ho Wu, Yun-Ming Wang, Tian-Lu Cheng, I-Ju Chen, Yun-Chi Lu, Kuo-Hsiang Chuang, Chih-Kuang Wang, Chiao-Yun Chen, Rui-An Lin, Huei-Jen Chen, Tzu-Yi Liao, En-Shuo Liu and Fang-Ming Chen

    Citation: Journal of Nanobiotechnology 2020 18:118

    Content type: Research

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  23. Stimulus-responsive therapy permits precise control of therapeutic effect only at lesion of interest, which determines it a promising method for diagnosis and imaging-guided precision therapy. The acid environ...

    Authors: Qiumei Lan, Rongbin Lu, Haimin Chen, Yunfen Pang, Feng Xiong, Chong Shen, Zainen Qin, Li Zheng, Guojie Xu and Jinmin Zhao

    Citation: Journal of Nanobiotechnology 2020 18:117

    Content type: Research

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  24. The management of metastatic cancer remains a major challenge in cancer therapy worldwide. The targeted delivery of chemotherapeutic drugs through rationally designed formulations is one potential therapeutic ...

    Authors: Ruoning Wang, Yujie Yang, Mengmeng Yang, Dandan Yuan, Jinyu Huang, Rui Chen, Honglan Wang, Lihong Hu, Liuqing Di and Junsong Li

    Citation: Journal of Nanobiotechnology 2020 18:116

    Content type: Research

    Published on:

  25. Glucocorticoids (GCs) show powerful treatment effect on rheumatoid arthritis (RA). However, the clinical application is limited by their nonspecific distribution after systemic administration, serious adverse ...

    Authors: Feili Yan, Zhirong Zhong, Yao Wang, Yue Feng, Zhiqiang Mei, Hui Li, Xiang Chen, Liang Cai and Chunhong Li

    Citation: Journal of Nanobiotechnology 2020 18:115

    Content type: Research

    Published on:

  26. Diacid metabolite as the stable form of norcantharidin (DM-NCTD) derived from Chinese blister beetle (Mylabris spp.). The previous studies reported that DM-NCTD could enhance ABT-737-triggered cell viability inhi...

    Authors: Minchen Liu, Jue Tu, Yi Feng, Jiquan Zhang and Jing Wu

    Citation: Journal of Nanobiotechnology 2020 18:114

    Content type: Short Communication

    Published on:

  27. Human mesenchymal stem cell (MSC)-derived exosomes (Exos) are a promising therapeutic agent for cell-free regenerative medicine. However, their poor organ-targeting ability and therapeutic efficacy have been f...

    Authors: Xiuying Li, Ying Wang, Liyan Shi, Binxi Li, Jing Li, Zhenhong Wei, Huiying Lv, Liya Wu, Hao Zhang, Bai Yang, Xiaohua Xu and Jinlan Jiang

    Citation: Journal of Nanobiotechnology 2020 18:113

    Content type: Research

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  28. A method with high sensitivity, good accuracy and fast response is of ever increasing importance for the simultaneous detection of AA, DA and UA. In this paper, a simple and sensitive electrochemical sensor, w...

    Authors: Yiyong Wu, Peihong Deng, Yaling Tian, Jinxia Feng, Jingyun Xiao, Junhua Li, Jun Liu, Guangli Li and Quanguo He

    Citation: Journal of Nanobiotechnology 2020 18:112

    Content type: Research

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  29. Electrospun (e-spun) nanofibers for wound dressing have attracted wide attention due to its large specific surface area, large porosity and breathability. Compared with solution electrospinning (e-spinning), m...

    Authors: Ying-Tao Zhao, Jun Zhang, Yuan Gao, Xiao-Fei Liu, Jiang-Jun Liu, Xiao-Xiong Wang, Hong-Fei Xiang and Yun-Ze Long

    Citation: Journal of Nanobiotechnology 2020 18:111

    Content type: Research

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  30. Due to the unexpected side effects of the iodinated contrast agents, novel contrast agents for X-ray computed tomography (CT) imaging are urgently needed. Nanoparticles made by heavy metal elements are often e...

    Authors: Ji-jun Fu, Jun-jie Guo, Ai-ping Qin, Xi-yong Yu, Qiang Zhang, Xue-ping Lei, Yu-gang Huang, Ming-yue Chen, Jie-xia Li, Yu Zhang, Jing-ping Liu, Yuan-ye Dang, Dan Wu, Xiao-ya Zhao, Zhong-xiao Lin, Yin-lei Lin…

    Citation: Journal of Nanobiotechnology 2020 18:110

    Content type: Research

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  31. Antisense oligonucleotides (ASOs) based technology is considered a potential strategy against antibiotic-resistant bacteria; however, a major obstacle to the application of ASOs is how to deliver them into bac...

    Authors: Yue Hu, Zhou Chen, Xinggang Mao, Mingkai Li, Zheng Hou, Jingru Meng, Xiaoxing Luo and Xiaoyan Xue

    Citation: Journal of Nanobiotechnology 2020 18:109

    Content type: Research

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  32. Drug delivery systems (DDSs) based on nanomaterials have shown a promise for cancer chemotherapy; however, it remains a great challenge to localize on-demand release of anticancer drugs in tumor tissues to imp...

    Authors: Xiaoying Wang, Zeliang Xuan, Xiaofeng Zhu, Haitao Sun, Jingchao Li and Zongyu Xie

    Citation: Journal of Nanobiotechnology 2020 18:108

    Content type: Review

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  33. Tuberculosis (TB) is a highly infectious disease caused by Mycobacterium tuberculosis (Mtb), which often parasites in macrophages. This study is performed to investigate the bactericidal effect and underlying mec...

    Authors: Shuang Xie, Gangjing Li, Yuru Hou, Min Yang, Fahui Li, Jianhu Li, Dairong Li and Yonghong Du

    Citation: Journal of Nanobiotechnology 2020 18:107

    Content type: Research

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  34. Topical isotretinoin is commonly used to treat acne. However, topical isotretinoin has side effects and can hardly permeate through the stratum corneum, the most important skin barrier. Therefore, this study a...

    Authors: Shiyi Wang, Rihua Jiang, Tianqi Meng, Fuqiang Zhang, Jing Li, Yongri Jin, JeungHoon Lee, Mingji Zhu and Jinlan Jiang

    Citation: Journal of Nanobiotechnology 2020 18:106

    Content type: Research

    Published on:

  35. Spinal cord injury (SCI) is a catastrophic injury that can cause irreversible motor dysfunction with high disability. Exosomes participate in the transport of miRNAs and play an essential role in intercellular...

    Authors: Dongdong Jiang, Fangyi Gong, Xuhui Ge, Chengtang Lv, Chenyu Huang, Shuang Feng, Zheng Zhou, Yuluo Rong, Jiaxing Wang, Chengyue Ji, Jian Chen, Wene Zhao, Jin Fan, Wei Liu and Weihua Cai

    Citation: Journal of Nanobiotechnology 2020 18:105

    Content type: Research

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  36. This study aimed to develop a ternary nanocomposite system of organoclay, glycol-chitosan, and Eudragit®S100 as an effective colon targeted drug delivery carrier to enhance the oral absorption of insulin. A nanoc...

    Authors: Sang Hoon Lee, Seung-Yun Back, Jae Geun Song and Hyo-Kyung Han

    Citation: Journal of Nanobiotechnology 2020 18:104

    Content type: Research

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  37. Selenium (Se) in soil mainly consists of selenite, selenate, and elemental Se. However, little is known about the mechanism involved in the uptake and biotransformation of elemental Se by plants.

    Authors: Kang Wang, Yaqi Wang, Kui Li, Yanan Wan, Qi Wang, Zhong Zhuang, Yanbin Guo and Huafen Li

    Citation: Journal of Nanobiotechnology 2020 18:103

    Content type: Research

    Published on:

  38. In this study, a multifunctional tetraphenylporphyrin (TPP) conjugated polyethylene glycol with biotin (TPP-PEG-biotin) as a photo-dynamic therapy (PDT) material encapsulating a ruthenium complex 1 (Ru-1) was ...

    Authors: Baskaran Purushothaman, Jeongmin Lee, Sera Hong and Joon Myong Song

    Citation: Journal of Nanobiotechnology 2020 18:102

    Content type: Research

    Published on:

  39. Cell membrane-based nanocarriers are promising candidates for delivering antitumor agents. The employment of a simple and feasible method to improve the tumor-targeting abilities of these systems is appealing ...

    Authors: Yin Chen, Xue Shen, Songling Han, Tao Wang, Jianqi Zhao, Yongwu He, Shilei Chen, Shengqi Deng, Cheng Wang and Junping Wang

    Citation: Journal of Nanobiotechnology 2020 18:101

    Content type: Research

    Published on:

  40. Plant-derived extracellular vesicles (PDEVs) have great potential for clinical applications. Ultracentrifugation, considered the gold standard method for the preparation of PDEVs, is efficacious but time-consu...

    Authors: Meng Yang, Xiaoyan Liu, Qingqiong Luo, Lili Xu and Fuxiang Chen

    Citation: Journal of Nanobiotechnology 2020 18:100

    Content type: Research

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  41. CuS-modified hollow mesoporous organosilica nanoparticles (HMON@CuS) have been preferred as non-invasive treatment for cancer, as near infrared (NIR)-induced photo-thermal effect (PTT) and/or photo-dynamic eff...

    Authors: Weihong Guo, Zhian Chen, Jiajia Chen, Xiaoli Feng, Yang Yang, Huilin Huang, Yanrui Liang, Guodong Shen, Yu Liang, Chao Peng, Yanbing Li, Guoxin Li, Wenhua Huang, Bingxia Zhao and Yanfeng Hu

    Citation: Journal of Nanobiotechnology 2020 18:99

    Content type: Research

    Published on:

  42. In this study, we aimed to design a novel oral insulin delivery system, named “oil-soluble” reversed lipid nanoparticles (ORLN), in which a hydrophilic insulin molecule is encapsulated by a phospholipid (PC) s...

    Authors: Tao Wang, Liao Shen, Yadan Zhang, Haiyan Li, Yongan Wang and Dongqin Quan

    Citation: Journal of Nanobiotechnology 2020 18:98

    Content type: Research

    Published on:

  43. Three-dimensional (3D) printing involves the layering of seed cells, biologically compatible scaffolds, and biological activity factors to precisely recapitulate a biological tissue. Graphene oxide (GO), a typ...

    Authors: Zhong Cheng, Li Xigong, Diao Weiyi, Hu Jingen, Wang Shuo, Lin Xiangjin and Wu Junsong

    Citation: Journal of Nanobiotechnology 2020 18:97

    Content type: Research

    Published on:

  44. The traditional treatment for diabetes usually requires frequent insulin injections to maintain normoglycemia, which is painful and difficult to achieve blood glucose control.

    Authors: Xia Zhou, Hongwei Wu, Ruimin Long, Shibin Wang, Haiwang Huang, Yanhua Xia, Pei Wang, Yifeng Lei, Yuanyuan Cai, Duanhua Cai and Yuangang Liu

    Citation: Journal of Nanobiotechnology 2020 18:96

    Content type: Research

    Published on:

  45. Currently, the diagnosis and treatment of neuroblastomas—the most frequent solid tumors in children—exploit the norepinephrine transporter (hNET) via radiolabeled norepinephrine analogs. We aim to develop a na...

    Authors: Yazan Haddad, Marketa Charousova, Hana Zivotska, Zbynek Splichal, Miguel Angel Merlos Rodrigo, Hana Michalkova, Sona Krizkova, Barbora Tesarova, Lukas Richtera, Petr Vitek, Kamila Stokowa-Soltys, David Hynek, Vedran Milosavljevic, Simona Rex and Zbynek Heger

    Citation: Journal of Nanobiotechnology 2020 18:95

    Content type: Research

    Published on:

  46. Celastrol has been proven effective in anti-inflammatory but was limited in the clinic due to the poor solubility and side effects induced by low bioavailability. Osteoarthritis has acidic and inflammatory env...

    Authors: Tian Jin, Di Wu, Xiao-Ming Liu, Jiang-Tao Xu, Bing-Jie Ma, Yun Ji, Yu-Ying Jin, Si-Yin Wu, Tao Wu and Ke Ma

    Citation: Journal of Nanobiotechnology 2020 18:94

    Content type: Research

    Published on:

  47. Since vascular endothelial growth factor (VEGF) is a significant regulator of cancer angiogenesis, it is essential to develop a technology for its sensitive detection. Herein, we sensitized a chemiluminescence...

    Authors: Fahimeh Ghavamipour, Hossein Rahmani, Maryam Shanehsaz, Khosro Khajeh, Manouchehr Mirshahi and Reza H. Sajedi

    Citation: Journal of Nanobiotechnology 2020 18:93

    Content type: Research

    Published on:

  48. Cell membrane- covered drug-delivery nanoplatforms have been garnering attention because of their enhanced bio-interfacing capabilities that originate from source cells. In this top-down technique, nanoparticl...

    Authors: Chunai Gong, Xiaoyan Yu, Benming You, Yan Wu, Rong Wang, Lu Han, Yujie Wang, Shen Gao and Yongfang Yuan

    Citation: Journal of Nanobiotechnology 2020 18:92

    Content type: Research

    Published on:

  50. Ovarian cancer is a highly aggressive malignant disease in gynecologic cancer. It is an urgent task to develop three-dimensional (3D) cell models in vitro and dissect the cell progression-related drug resistan...

    Authors: Hong Song, Guo-hui Cai, Jian Liang, Di-shu Ao, Huan Wang and Ze-hong Yang

    Citation: Journal of Nanobiotechnology 2020 18:90

    Content type: Research

    Published on:

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