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  1. Photothermal therapy (PTT) has been extensively investigated as a tumor-localizing therapeutic modality for neoplastic disorders. However, the hyperthermia effect of PTT is greatly restricted by the thermoresi...

    Authors: Xinzhu Shan, Xuanbo Zhang, Chen Wang, Zhiqiang Zhao, Shenwu Zhang, Yuequan Wang, Bingjun Sun, Cong Luo and Zhonggui He

    Citation: Journal of Nanobiotechnology 2021 19:282

    Content type: Research

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  2. Spinal cord injury (SCI) is damage to the central nervous system (CNS) that causes devastating complications from chronic pain to breathing problems. Unfortunately, few effective and safe treatments are known ...

    Authors: Sen Lin, Dan Li, Zipeng Zhou, Chang Xu, Xifan Mei and He Tian

    Citation: Journal of Nanobiotechnology 2021 19:281

    Content type: Research

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  3. Electrostimulation (ES) therapy for wound healing is limited in clinical use due to barriers such as cumbersome equipment and intermittent delivery of therapy.

    Authors: Aiping Liu, Yin Long, Jun Li, Long Gu, Aos Karim, Xudong Wang and Angela L. F. Gibson

    Citation: Journal of Nanobiotechnology 2021 19:280

    Content type: Research

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  4. Gold nanoparticles (AuNP) are effective radiosensitisers, however, successful clinical translation has been impeded by short systemic circulation times and poor internalisation efficiency. This work examines t...

    Authors: Lindsey A. Bennie, Jie Feng, Christopher Emmerson, Wendy B. Hyland, Kyle B. Matchett, Helen O. McCarthy and Jonathan A. Coulter

    Citation: Journal of Nanobiotechnology 2021 19:279

    Content type: Research

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  5. Authors: Rong Huang, Guang-Qing Cai, Jian Li, Xi-Sheng Li, Hai-Ting Liu, Xue-Ling Shang, Jian-Dang Zhou, Xin-Min Nie and Rong Gui

    Citation: Journal of Nanobiotechnology 2021 19:278

    Content type: Correction

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    The original article was published in Journal of Nanobiotechnology 2021 19:229

  6. Salinity is a big threat to agriculture by limiting crop production. Nanopriming (seed priming with nanomaterials) is an emerged approach to improve plant stress tolerance; however, our knowledge about the und...

    Authors: Mohammad Nauman Khan, Yanhui Li, Zaid Khan, Linlin Chen, Jiahao Liu, Jin Hu, Honghong Wu and Zhaohu Li

    Citation: Journal of Nanobiotechnology 2021 19:276

    Content type: Research

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  7. Skin injury and the resultant defects are common clinical problems, and usually lead to chronic skin ulcers and even life-threatening diseases. Copper, an essential trace element of human body, has been report...

    Authors: Tian-Long Wang, Zi-Fei Zhou, Jun-Feng Liu, Xiao-Dong Hou, Zhi Zhou, Yun-Lu Dai, Zhi-Yong Hou, Feng Chen and Long-Po Zheng

    Citation: Journal of Nanobiotechnology 2021 19:275

    Content type: Research

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  8. Spinal cord injury (SCI) is an inflammatory condition, and excessive adenosine triphosphate (ATP) is released into the extracellular space, which can be catabolized into adenosine by CD73. Extracellular vesicl...

    Authors: Xiao Zhai, Kai Chen, Huan Yang, Bo Li, Tianjunke Zhou, Haojue Wang, Huipeng Zhou, Shaofeng Chen, Xiaoyi Zhou, Xiaozhao Wei, Yushu Bai and Ming Li

    Citation: Journal of Nanobiotechnology 2021 19:274

    Content type: Research

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  9. The control of contagious or refractory diseases requires early, rapid diagnostic assays that are simple, fast, and easy-to-use. Here, easy-to-implement CRISPR/Cas12a-based diagnostic platform through Raman tr...

    Authors: Jiajie Liang, Peijun Teng, Wei Xiao, Guanbo He, Qifang Song, Ying Zhang, Bin Peng, Gan Li, Liangshan Hu, Donglin Cao and Yong Tang

    Citation: Journal of Nanobiotechnology 2021 19:273

    Content type: Research

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  10. Retinol binding protein 4 (RBP4) has been regarded as an important serological biomarker for type 2 diabetes mellitus (T2DM). Hence, the construction of a highly sensitive detection method for RBP4 is the key ...

    Authors: Wei Gong, Suqing Yang, Fen Zhang, Fengshun Tian, Junman Chen, Zhigang Yin, Shijia Ding, Wei Yang and Rong Luo

    Citation: Journal of Nanobiotechnology 2021 19:272

    Content type: Research

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  11. Myocardial infarction (MI) is one of the leading causes of global death. Dendritic cell-derived exosomes (DEXs) provide us with the possibility of improving cardiac function after MI but are limited by low ret...

    Authors: Youming Zhang, Zichun Cai, Yunli Shen, Qizheng Lu, Wei Gao, Xin Zhong, Kang Yao, Jie Yuan and Haibo Liu

    Citation: Journal of Nanobiotechnology 2021 19:271

    Content type: Research

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  12. Rotator cuff tear (RCT) is a common problem of the musculoskeletal system. With the advantage of promoting bone formation, calcium phosphate materials have been widely used to augment tendon-bone healing. Howe...

    Authors: Haoran Liao, Han-Ping Yu, Wei Song, Guangcheng Zhang, Bingqiang Lu, Ying-Jie Zhu, Weilin Yu and Yaohua He

    Citation: Journal of Nanobiotechnology 2021 19:270

    Content type: Research

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  13. Many patients suffer from implant loosening after the implantation of titanium alloy caused by immune response to the foreign bodies and this could inhibit the following osteogenesis, which could possibly give...

    Authors: Wei Liu, Muyu Yu, Feng Chen, Longqing Wang, Cheng Ye, Qing Chen, Qi Zhu, Dong Xie, Mingzhe Shao and Lili Yang

    Citation: Journal of Nanobiotechnology 2021 19:269

    Content type: Research

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  14. Tumor-associated macrophages (TAMs) are the most abundant stromal cells in the tumor microenvironment. Turning the TAMs against their host tumor cells is an intriguing therapeutic strategy particularly attract...

    Authors: Hua-Zhen Xu, Tong-Fei Li, Chao Wang, Yan Ma, Yan Liu, Mei-Yan Zheng, Zhang-Jun-Yan Liu, Jin-Bo Chen, Ke Li, Shi-Kuan Sun, Naoki Komatsu, Yong-Hong Xu, Li Zhao and Xiao Chen

    Citation: Journal of Nanobiotechnology 2021 19:268

    Content type: Research

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  15. Sarcomas comprise a group of aggressive malignancies with very little treatment options beyond standard chemotherapy. Reposition of approved drugs represents an attractive approach to identify effective therap...

    Authors: Óscar Estupiñán, Enrique Niza, Iván Bravo, Verónica Rey, Juan Tornín, Borja Gallego, Pilar Clemente-Casares, Francisco Moris, Alberto Ocaña, Verónica Blanco-Lorenzo, Mar Rodríguez-Santamaría, Aitana Vallina-Álvarez, M. Victoria González, Aida Rodríguez, Daniel Hermida-Merino, Carlos Alonso-Moreno…

    Citation: Journal of Nanobiotechnology 2021 19:267

    Content type: Research

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  16. Acute kidney injury (AKI) with high mortality rates is associated with an excess of reactive oxygen/nitrogen species (RONS) within kidney tissues. Recently, nanomedicine antioxidant therapy has been used to al...

    Authors: Dong-Yang Zhang, Hengke Liu, Kathy S. Zhu, Ting He, Muhammad Rizwan Younis, Chen Yang, Shan Lei, Jiayingzi Wu, Jing Lin, Junle Qu and Peng Huang

    Citation: Journal of Nanobiotechnology 2021 19:266

    Content type: Research

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  17. Though the combination of photodynamic therapy (PDT) and chemodynamic therapy (CDT) appears to be very attractive in cancer treatment, hypoxia and overproduced glutathione (GSH) in the tumor microenvironment (...

    Authors: Li Zhang, Yadi Fan, Zhe Yang, Mo Yang and Chun-Yuen Wong

    Citation: Journal of Nanobiotechnology 2021 19:265

    Content type: Research

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  18. Exosome therapy is a promising therapeutic approach for intervertebral disc degeneration (IVDD) and achieves its therapeutic effects by regulating metabolic disorders, the microenvironment and cell homeostasis...

    Authors: Hongyuan Xing, Zengjie Zhang, Qijiang Mao, Chenggui Wang, Youlong Zhou, Xiaopeng Zhou, Liwei Ying, Haibin Xu, Shaojun Hu and Ning Zhang

    Citation: Journal of Nanobiotechnology 2021 19:264

    Content type: Research

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  19. Melatonin has been proposed as a potent anticarcinogen presents a short half-life for osteosarcoma (OS). Cell-in-cell (CIC) structures play a role in the development of malignant tumors by changing the tumor c...

    Authors: Weilin Zhang, Wei Zhao, Qin Li, Duoyi Zhao, Junxing Qu, Ziyang Yuan, Zhihong Cheng, Xiaojuan Zhu, Xiuli Zhuang and Zhiyu Zhang

    Citation: Journal of Nanobiotechnology 2021 19:263

    Content type: Research

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  20. Photothermal therapy (PTT) is an emerging anti-cancer therapeutic strategy that generates hyperthermia to ablate cancer cells under laser irradiation. Gold (Au) coated liposome (AL) was reported as an effectiv...

    Authors: Miyeon Jeon, Gaeun Kim, Wooseung Lee, Seungki Baek, Han Na Jung and Hyung-Jun Im

    Citation: Journal of Nanobiotechnology 2021 19:262

    Content type: Research

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  21. Chemodynamic therapy (CDT), employing Fenton or Fenton-like catalysts to convert hydrogen peroxide (H2O2) into toxic hydroxyl radicals (·OH) to kill cancer cells, holds great promise in tumor therapy due to its h...

    Authors: Lulu Zhou, Jinjin Chen, Yunhao Sun, Keke Chai, Zhounan Zhu, Chunhui Wang, Mengyao Chen, Wenmei Han, Xiaochun Hu, Ruihao Li, Tianming Yao, Hui Li, Chunyan Dong and Shuo Shi

    Citation: Journal of Nanobiotechnology 2021 19:261

    Content type: Research

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  22. Fluorescent carbon-dots (CDs) with multifaceted advantages have provided hope for improvement of crop growth. Near infrared (NIR) CDs would be more competitive and promising than short-wavelength emissive CDs,...

    Authors: Yuhui Wang, Zhuomi Xie, Xiuhua Wang, Xin Peng and Jianping Zheng

    Citation: Journal of Nanobiotechnology 2021 19:260

    Content type: Research

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  23. Plant-derived extracellular vesicles (PDEVs) have been exploited for cancer treatment with several benefits. Bitter melon is cultivated as a vegetable and folk medicine with anticancer and anti-inflammatory ac...

    Authors: Meng Yang, Qingqiong Luo, Xu Chen and Fuxiang Chen

    Citation: Journal of Nanobiotechnology 2021 19:259

    Content type: Research

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  24. The rational chemical design of nanoparticles can be readily controlled and optimized by quantitatively studying protein adsorption at variously charged polymer carriers, determining their fate in biological f...

    Authors: Maria Dąbkowska, Zofia Ulańczyk, Karolina Łuczkowska, Dorota Rogińska, Anna Sobuś, Monika Wasilewska, Maria Olszewska, Katarzyna Jakubowska and Bogusław Machaliński

    Citation: Journal of Nanobiotechnology 2021 19:258

    Content type: Research

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  25. Cerebral infarction and cerebral hemorrhage, also known as “stroke”, is one of the leading cause of death. At present, there is no real specific medicine for stroke. Crinis Carbonisatus (named Xue-yu-tan in Chine...

    Authors: Yue Zhang, Suna Wang, Fang Lu, Meiling Zhang, Hui Kong, Jinjun Cheng, Juan Luo, Yan Zhao and Huihua Qu

    Citation: Journal of Nanobiotechnology 2021 19:257

    Content type: Research

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  26. Due to the global rise of the human population, one of the top-most challenges for poor and developing nations is to use the food produces safely and sustainably. In this regard, the storage of surplus food (a...

    Authors: Antul Kumar, Anuj Choudhary, Harmanjot Kaur, Sahil Mehta and Azamal Husen

    Citation: Journal of Nanobiotechnology 2021 19:256

    Content type: Review

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  27. Although nanomedicine have greatly developed and human life span has been extended, we have witnessed the soared incidence of central nervous system (CNS) diseases including neurodegenerative diseases (Alzheim...

    Authors: Ying Zhang, Pan Guo, Zhe Ma, Peng Lu, Dereje Kebebe and Zhidong Liu

    Citation: Journal of Nanobiotechnology 2021 19:255

    Content type: Review

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  28. Developing novel photosensitizers for deep tissue imaging and efficient photodynamic therapy (PDT) remains a challenge because of the poor water solubility, low reactive oxygen species (ROS) generation efficie...

    Authors: Xuzi Cai, Kang-Nan Wang, Wen Ma, Yuanyuan Yang, Gui Chen, Huijiao Fu, Chunhui Cui, Zhiqiang Yu and Xuefeng Wang

    Citation: Journal of Nanobiotechnology 2021 19:254

    Content type: Research

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  29. Peptide molecule has high bioactivity, good biocompatibility, and excellent biodegradability. In addition, it has adjustable amino acid structure and sequence, which can be flexible designed and tailored to fo...

    Authors: Yan Wang, Xiaoyuan Zhang, Keming Wan, Nan Zhou, Gang Wei and Zhiqiang Su

    Citation: Journal of Nanobiotechnology 2021 19:253

    Content type: Review

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  30. The niche of tissue development in vivo involves the growth matrix, biophysical cues and cell-cell interactions. Although natural extracellular matrixes may provide good supporting for seeding cells in vitro, ...

    Authors: Rui Bai, Jianfeng Liu, Jiao Zhang, Jinmiao Shi, Zhigeng Jin, Yi Li, Xiaoyu Ding, Xiaoming Zhu, Chao Yuan, Bingshui Xiu, Huiliang Liu, Zengqiang Yuan and Zhiqiang Liu

    Citation: Journal of Nanobiotechnology 2021 19:252

    Content type: Research

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  31. Glioblastoma is a lethal neoplasm with few effective therapy options. As a mainstay in the current treatment of glioma at present, chemotherapeutic agents usually show inadequate therapeutic efficiency due to ...

    Authors: Jiangkang Xu, Xiaoye Yang, Jianbo Ji, Yuan Gao, Na Qiu, Yanwei Xi, Anchang Liu and Guangxi Zhai

    Citation: Journal of Nanobiotechnology 2021 19:251

    Content type: Research

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  32. Tetraspanin expression of extracellular vesicles (EVs) is often used as a surrogate for their detection and classification, a practice that typically assumes their consistent expression across EV sources.

    Authors: Rachel R. Mizenko, Terza Brostoff, Tatu Rojalin, Hanna J. Koster, Hila S. Swindell, Gary S. Leiserowitz, Aijun Wang and Randy P. Carney

    Citation: Journal of Nanobiotechnology 2021 19:250

    Content type: Research

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  33. Discovery of early-stage biomarkers is a long-sought goal of Alzheimer’s disease (AD) diagnosis. Age is the greatest risk factor for most AD and accumulating evidence suggests that age-dependent elevation of a...

    Authors: Shan-Shan Wang, Zi-Kai Liu, Jing-Jing Liu, Qing Cheng, Yan-Xia Wang, Yan Liu, Wen-Wen Ni, Hong-Zhuan Chen and Mingke Song

    Citation: Journal of Nanobiotechnology 2021 19:249

    Content type: Research

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  34. Osteoporosis (OP) is a systemic skeletal disease marked by bone mass reduction and bone tissue destruction. Hormone replacement therapy is an effective treatment for post-menopausal OP, but estrogen has poor t...

    Authors: Yuanyuan Guo, Yongwei Liu, Chen Shi, Tingting Wu, Yongzhi Cui, Siyuan Wang, Ping Liu, Xiaobo Feng, Yu He and Dehao Fu

    Citation: Journal of Nanobiotechnology 2021 19:248

    Content type: Research

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  35. The regeneration of periodontal bone defect remains a vital clinical challenge. To date, numerous biomaterials have been applied in this field. However, the immune response and vascularity in defect areas may ...

    Authors: Tian Ding, Wenyan Kang, Jianhua Li, Lu Yu and Shaohua Ge

    Citation: Journal of Nanobiotechnology 2021 19:247

    Content type: Research

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  36. Hypoxic tumor microenvironment (TME) promotes tumor metastasis and drug resistance, leading to low efficiency of cancer chemotherapy. The development of targeted agents or multi-target therapies regulating hyp...

    Authors: Yan Chen, Lei Fang, Weixin Zhou, Jinghan Chang, Xiaojuan Zhang, Chuanchuan He, Chen Chen, Ruicong Yan, Yakai Yan, Yao Lu, Chuanrui Xu and Guangya Xiang

    Citation: Journal of Nanobiotechnology 2021 19:246

    Content type: Research

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  37. A red blood cell membrane (RBCm)-derived drug delivery system allows prolonged circulation of an antitumor treatment and overcomes the issue of accelerated blood clearance induced by PEGylation. However, RBCm-...

    Authors: Yongtai Zhang, Qing Xia, Tong Wu, Zehui He, Yanyan Li, Zhe Li, Xuefeng Hou, Yuanzhi He, Shuyao Ruan, Zhi Wang, Jia Sun and Nianping Feng

    Citation: Journal of Nanobiotechnology 2021 19:245

    Content type: Research

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  38. Macromoleculization of nitroxides has been an effective strategy to improve low relaxivities and poor in vivo stability, however, nitroxides-based metal-free magnetic resonance imaging (MRI) macromolecular con...

    Authors: Shiwei Guo, Xiaoming Wang, Zhiqian Li, Dayi Pan, Yan Dai, Yun Ye, Xiaohe Tian, Zhongwei Gu, Qiyong Gong, Hu Zhang and Kui Luo

    Citation: Journal of Nanobiotechnology 2021 19:244

    Content type: Research

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  39. The clinical treatment of metastatic spinal tumor remains a huge challenge owing to the intrinsic limitations of the existing methods. Programmed cell death protein 1 (PD1)/programmed cell death ligand 1 (PD-L...

    Authors: Zhenqing Wang, Liang Chen, Yiqun Ma, Xilei Li, Annan Hu, Huiren Wang, Wenxing Wang, Xiaomin Li, Bo Tian and Jian Dong

    Citation: Journal of Nanobiotechnology 2021 19:243

    Content type: Research

    Published on:

  40. Exosomes are lipid bilayer membrane vesicles and are emerging as competent nanocarriers for drug delivery. The clinical translation of exosomes faces many challenges such as massive production, standard isolat...

    Authors: Yong-Jiang Li, Jun-Yong Wu, Jihua Liu, Wenjie Xu, Xiaohan Qiu, Si Huang, Xiong-Bin Hu and Da-Xiong Xiang

    Citation: Journal of Nanobiotechnology 2021 19:242

    Content type: Review

    Published on:

  41. Bacterial proliferation on the endosseous implants surface presents a new threat to the using of the bone implants. Unfortunately, there is no effective constructed antibacterial coating which is bacterial ant...

    Authors: Xin Liao, Xingfang Yu, Haiping Yu, Jiaqi Huang, Bi Zhang and Jie Xiao

    Citation: Journal of Nanobiotechnology 2021 19:241

    Content type: Research

    Published on:

  42. There has been a great interest in developing strategies for enhancing antigen delivery to the mucosal immune system as well as identifying mucosal active immunostimulating agents. To elevate the potential of O-2...

    Authors: Kai Zhao, Beini Sun, Ci Shi, Yanwei Sun, Zheng Jin and Gaowei Hu

    Citation: Journal of Nanobiotechnology 2021 19:240

    Content type: Research

    Published on:

  43. Applied nanomaterials in targeted drug delivery have received increased attention due to tangible advantages, including enhanced cell adhesion and internalization, controlled targeted release, convenient detec...

    Authors: Reza Taheri-Ledari, Wenjie Zhang, Maral Radmanesh, Nicole Cathcart, Ali Maleki and Vladimir Kitaev

    Citation: Journal of Nanobiotechnology 2021 19:239

    Content type: Research

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  44. Cancer synergistic therapy strategy in combination with therapeutic gene and small molecule drug offers the possibility to amplify anticancer efficiency. Colon cancer-associated transcript-1 (CCAT1) is a well ...

    Authors: Fan Jia, Yunhao Li, Xiongwei Deng, Xuan Wang, Xinyue Cui, Jianqing Lu, Zian Pan and Yan Wu

    Citation: Journal of Nanobiotechnology 2021 19:238

    Content type: Research

    Published on:

  45. During wound healing, the overproduction of reactive oxygen species (ROS) can break the cellular oxidant/antioxidant balance, which prolongs healing. The wound dressings targeting the mitigation of ROS will be...

    Authors: Qianmin Ou, Shaohan Zhang, Chuanqiang Fu, Le Yu, Peikun Xin, Zhipeng Gu, Zeyuan Cao, Jun Wu and Yan Wang

    Citation: Journal of Nanobiotechnology 2021 19:237

    Content type: Research

    Published on:

  46. Recently, we designed novel amphipathic cell-penetrating peptides, called WRAP, able to transfer efficiently siRNA molecules into cells. In order to gain more information about the relationship between amino a...

    Authors: Karidia Konate, Emilie Josse, Milana Tasic, Karima Redjatti, Gudrun Aldrian, Sébastien Deshayes, Prisca Boisguérin and Eric Vivès

    Citation: Journal of Nanobiotechnology 2021 19:236

    Content type: Research

    Published on:

  47. Pregnancy exposure to titanium dioxide nanoparticles (TiO2NPs) is a vital consideration due to their inadvertent ingestion from environmental contamination. The potential health effects of TiO2NPs on the neurodev...

    Authors: Junhao Su, Xinhao Duan, Yu Qiu, Lixiao Zhou, Hongyang Zhang, Min Gao, Yijun Liu, Zhen Zou, Jingfu Qiu and Chengzhi Chen

    Citation: Journal of Nanobiotechnology 2021 19:234

    Content type: Research

    Published on:

  48. Biofilm formation is one of the main reasons for persistent bacterial infections. Recently, pH-sensitive copolymers have fascinated incredible attention to tackle biofilm-related infections. However, the prope...

    Authors: Rong Guo, Keke Li, Baocheng Tian, Changrong Wang, Xiangjun Chen, Xinyu Jiang, Huayu He and Wei Hong

    Citation: Journal of Nanobiotechnology 2021 19:232

    Content type: Research

    Published on:

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