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  1. Skin tissue is vital in protecting the body from injuries and bacterial infections. Wound infection caused by bacterial colonization is one of the main factors hindering wound healing. Wound infection caused b...

    Authors: Yapeng Lu, Meihui Zhao, Ye Peng, Sizhe He, Xiaopeng Zhu, Chao Hu, Guanghua Xia, Tao Zuo, Xueying Zhang, Yonghuan Yun, Weimin Zhang and Xuanri Shen
    Citation: Journal of Nanobiotechnology 2022 20:426
  2. Poor in vivo targeting of tumors by chemotherapeutic drugs reduces their anti-cancer efficacy in the clinic. The discovery of over-expressed components on the tumor cell surface and their specific ligands prov...

    Authors: Bing Zhang, Ying Zhang, Wenli Dang, Bin Xing, Changxiang Yu, Pan Guo, Jiaxin Pi, Xiuping Deng, Dongli Qi and Zhidong Liu
    Citation: Journal of Nanobiotechnology 2022 20:425
  3. Nanozymes are promising for precise cancer treatment, but are typically limited in terms of the low catalytic efficiency and the complexity in tumor microenvironment (TME). Herein, we describe a bimodal type o...

    Authors: Tao Jia, Dan Li, Jiarui Du, Xikui Fang, Valeriy Gerasimov, Hans Ågren and Guanying Chen
    Citation: Journal of Nanobiotechnology 2022 20:424
  4. Patients with critical limb ischemia (CLI) are at great risk of major amputation and cardiovascular events. Adipose-derived mesenchymal stem cell (ADSC) therapy is a promising therapeutic strategy for CLI, but...

    Authors: Zekun Shen, Weiyi Wang, Jinxing Chen, Bingyi Chen, Yanan Tang, Jiaxuan Hou, Jiayan Li, Shuang Liu, Yifan Mei, Liwei Zhang and Shaoying Lu
    Citation: Journal of Nanobiotechnology 2022 20:422
  5. Light-mediated nanotherapeutics have recently emerged as promising strategies to precisely control the activation of therapeutic reagents and imaging probe both in vitro and in vivo, largely ascribed to their ...

    Authors: Dan Zhao, Wang Zhang, Shuang Yu, Si-Lei Xia, Ya-Nan Liu and Guan-Jun Yang
    Citation: Journal of Nanobiotechnology 2022 20:421
  6. Intervertebral disc degeneration (IDD) is the pathological reason of back pain and the therapeutic approaches are still unsatisfactory. Recently, mesenchymal stem cell-derived small extracellular vesicles (EVs...

    Authors: Zhiwei Liao, Wencan Ke, Hui Liu, Bide Tong, Kun Wang, Xiaobo Feng, Wenbin Hua, Bingjin Wang, Yu Song, Rongjin Luo, Huaizhen Liang, Weifeng Zhang, Kangcheng Zhao, Shuai Li and Cao Yang
    Citation: Journal of Nanobiotechnology 2022 20:420
  7. Targeting cartilage is a promising strategy for the treatment of osteoarthritis, and various delivery vehicles were developed to assist the therapeutic agents into cartilage. However, the underlying biomechani...

    Authors: Zengxin Jiang, Hao Wang, Zeng Zhang, Jianfeng Pan and Hengfeng Yuan
    Citation: Journal of Nanobiotechnology 2022 20:419
  8. The cell/microenvironment interface is the starting point of integrin-mediated mechanotransduction, but many details of mechanotransductive signal integration remain elusive due to the complexity of the involv...

    Authors: Matteo Chighizola, Tania Dini, Stefania Marcotti, Mirko D’Urso, Claudio Piazzoni, Francesca Borghi, Anita Previdi, Laura Ceriani, Claudia Folliero, Brian Stramer, Cristina Lenardi, Paolo Milani, Alessandro Podestà and Carsten Schulte
    Citation: Journal of Nanobiotechnology 2022 20:418
  9. While improvements in immunoradiotherapy have significantly improved outcomes for cancer patients, this treatment approach has nevertheless proven ineffective at controlling the majority of malignancies. One o...

    Authors: Yun Hu, Sébastien Paris, Genevieve Bertolet, Hampartsoum B. Barsoumian, Kewen He, Duygu Sezen, Dawei Chen, Mark Wasley, Jordan DA SILVA, Joylise A. Mitchell, Tiffany A. Voss, Fatemeh Masrorpour, Claudia Kettlun Leyton, Liangpeng Yang, Carola Leuschner, Nahum Puebla-Osorio…
    Citation: Journal of Nanobiotechnology 2022 20:417
  10. Drug resistance of pathogens and immunosuppression are the main causes of clinical stagnation of osteomyelitis. The ideal treatment strategy for osteomyelitis is to achieve both efficient antibacterial and bon...

    Authors: Xiaoting Xie, Jiemao Wei, Bin Zhang, Wei Xiong, Zhiyi He, Yayun Zhang, Chenghao Gao, Yuandi Zhao and Bo Liu
    Citation: Journal of Nanobiotechnology 2022 20:416
  11. Gastrointestinal cancer (GIC) is a common malignant tumour of the digestive system that seriously threatens human health. Due to the unique organ structure of the gastrointestinal tract, endoscopic and MRI dia...

    Authors: Shenghe Deng, Junnan Gu, Zhenxing Jiang, Yinghao Cao, Fuwei Mao, Yifan Xue, Jun Wang, Kun Dai, Le Qin, Ke Liu, Ke Wu, Qianyuan He and Kailin Cai
    Citation: Journal of Nanobiotechnology 2022 20:415
  12. The chemotherapy effect of docetaxel (DTX) against triple-negative breast cancer (TNBC) remains mediocre and limited when encapsulated in conventional cholesterol liposomes, mainly ascribed to poor penetration...

    Authors: Jiaxuan Xia, Shuya Zhang, Ru Zhang, Anni Wang, Ying Zhu, Meichen Dong, Shaojie Ma, Chao Hong, Shengyao Liu, Dan Wang and Jianxin Wang
    Citation: Journal of Nanobiotechnology 2022 20:414
  13. Parkinson’s disease (PD) significantly affects patients’ quality of life and represents a high economic burden for health systems. Given the lack of safe and effective treatments for PD, drug repositioning see...

    Authors: Héctor Hernández-Parra, Hernán Cortés, José Arturo Avalos-Fuentes, María Del Prado-Audelo, Benjamín Florán, Gerardo Leyva-Gómez, Javad Sharifi-Rad and William C. Cho
    Citation: Journal of Nanobiotechnology 2022 20:413
  14. Besides the broad development of nanotechnological approaches for cancer diagnosis and therapy, currently, there is no significant progress in the treatment of different types of brain tumors. Therapeutic mole...

    Authors: Ksenia Mitusova, Oleksii O. Peltek, Timofey E. Karpov, Albert R. Muslimov, Mikhail V. Zyuzin and Alexander S. Timin
    Citation: Journal of Nanobiotechnology 2022 20:412
  15. The major challenge to controlling the COVID pandemic is the rapid mutation rate of the SARS-CoV-2 virus, leading to the escape of the protection of vaccines and most of the neutralizing antibodies to date. Th...

    Authors: Dongping Zhao, Liqin Liu, Xinlin Liu, Jinlei Zhang, Yuqing Yin, Linli Luan, Dingwen Jiang, Xiong Yang, Lei Li, Hualong Xiong, Dongming Xing, Qingbing Zheng, Ningshao Xia, Yuyong Tao, Shaowei Li and Haiming Huang
    Citation: Journal of Nanobiotechnology 2022 20:411
  16. Photodynamic therapy (PDT) has emerged as a promising tumor treatment method via light-triggered generation of reactive oxygen species (ROS) to kill tumor cells. However, the efficacy of PDT is usually restric...

    Authors: Xiaoxiong Xiao, Min Chen, Yuchen Zhang, Liang Li, Ying Peng, Wenhu Zhou and Junyu Li
    Citation: Journal of Nanobiotechnology 2022 20:410
  17. Radiation-induced skin injury (RISI) is an important challenge for clinical treatments. The main causes of RISI include hypoxia in the wound microenvironment, reactive oxygen species (ROS) activation, and down...

    Authors: Daijun Zhou, Min Du, Han Luo, Fengwei Ran, Xiang Zhao, Yan Dong, Tao Zhang, Jie Hao, Dong Li and Jianjun Li
    Citation: Journal of Nanobiotechnology 2022 20:409
  18. Nanofabrication technologies have been recently applied to the development of engineered nano–bio interfaces for manipulating complex cellular processes. In particular, vertically configurated nanostructures s...

    Authors: Yaping Chen, Hao Zhe Yoh, Ali-Reza Shokouhi, Takahide Murayama, Koukou Suu, Yasuhiro Morikawa, Nicolas H. Voelcker and Roey Elnathan
    Citation: Journal of Nanobiotechnology 2022 20:406
  19. Septic heart failure accounts for high mortality rates globally. With a strong reducing capacity, zero-valent iron nanoparticles (nanoFe) have been applied in many fields. However, the precise roles and mechan...

    Authors: Daquan Wang, Changyu Wang, Zhenxing Liang, Wangrui Lei, Chao Deng, Xiaoli Liu, Shuai Jiang, Yanli Zhu, Shaofei Zhang, Wenwen Yang, Ying Chen, Yao Qiu, Lingjie Meng and Yang Yang
    Citation: Journal of Nanobiotechnology 2022 20:405
  20. Ulcerative colitis (UC) is a major type of inflammatory bowel disease (IBD), which could induce bloody stool, diarrhea, colon atrophy and eventually lead to colorectal cancer. The conventional daily oral admin...

    Authors: Meng Gao, Chen Yang, Chenghu Wu, Yue Chen, Hongqin Zhuang, Jilong Wang and Zhiting Cao
    Citation: Journal of Nanobiotechnology 2022 20:404
  21. The current diagnosis and treatment of sarcoma continue to show limited timeliness and efficacy. In order to enable the early detection and management of sarcoma, increasing attentions have been given to the t...

    Authors: Huali Ye, Xin Hu, Yang Wen, Chongqi Tu, Francis Hornicek, Zhenfeng Duan and Li Min
    Citation: Journal of Nanobiotechnology 2022 20:403
  22. 7-p-trifluoromethylphenyl-FL118 (FLQY2) is a camptothecin analog with excellent antitumor efficacy against various solid tumors. However, its poor solubility and low bioavailability limited the development of ...

    Authors: Yi Wang, Wenchao Wang, Endian Yu, Wenya Zhuang, Xuanrong Sun, Hong Wang and Qingyong Li
    Citation: Journal of Nanobiotechnology 2022 20:402
  23. Cancer cell membrane-camouflaged nanotechnology for metal complex can enhance its biocompatibility and extend the effective circulation time in body. The ruthenium polypyridyl complex (RuPOP) has extensive ant...

    Authors: Xiaoying Li, Yanzi Yu, Qi Chen, Jiabao Lin, Xueqiong Zhu, Xiaoting Liu, Lizhen He, Tianfeng Chen and Weiling He
    Citation: Journal of Nanobiotechnology 2022 20:401
  24. Sepsis is caused mainly by infection in the blood with a broad range of bacterial species. It can be diagnosed by molecular diagnostics once compounds in the blood that interfere with molecular diagnostics are...

    Authors: Abdurhaman Teyib Abafogi, Tepeng Wu, Daekyu Lee, Jinyeop Lee, Gyoujin Cho, Luke P. Lee and Sungsu Park
    Citation: Journal of Nanobiotechnology 2022 20:400
  25. Effective therapeutics and vaccines for coronavirus disease 2019 (COVID-19) are currently lacking because of the mutation and immune escape of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2). Base...

    Authors: Xiaoli Wu, Junye Liu, Hongpeng Zhang, Hua Zhou, Wen Wang, Yuanyan Ma, Shimei Shen, Xuefei Cai, Ailong Huang and Deqiang Wang
    Citation: Journal of Nanobiotechnology 2022 20:399
  26. The ideal neural interface or scaffold for stem cell therapy shall have good biocompatibility promoting survival, maturation and integration of neural stem cells (NSCs) in targeted brain regions. The unique el...

    Authors: Yige Li, Yangnan Hu, Hao Wei, Wei Cao, Yanru Qi, Shan Zhou, Panpan Zhang, Huawei Li, Geng-Lin Li and Renjie Chai
    Citation: Journal of Nanobiotechnology 2022 20:398
  27. Ischemic stroke is one of the most serious global public health problems. However, the performance of current therapeutic regimens is limited due to their poor target specificity, narrow therapeutic time windo...

    Authors: Ranran Duan, Ke Sun, Fang Fang, Ning Wang, Ruya He, Yang Gao, Lijun Jing, Yanfei Li, Zhe Gong, Yaobing Yao, Tingting Luan, Chaopeng Zhang, Jinwei Zhang, Yi Zhao, Haojie Xie, Yongyan Zhou…
    Citation: Journal of Nanobiotechnology 2022 20:397
  28. The abnormal expression of long non-coding RNAs (LncRNAs) in platelet-derived microparticles (PMPs) is closely related to immune disorders and may lead to antiphospholipid antibody syndrome and recurrent misca...

    Authors: Zhiwei Sun, Qian Zhou, Yufei Yang, Lei Li, Mengru Yu, Hui Li, Aihua Li, Xietong Wang and Yanyan Jiang
    Citation: Journal of Nanobiotechnology 2022 20:396
  29. The rapid advancement of nanomedicine and nanoparticle (NP) materials presents novel solutions potentially capable of revolutionizing health care by improving efficacy, bioavailability, drug targeting, and saf...

    Authors: Saquib Waheed, Zhibin Li, Fangyingnan Zhang, Anna Chiarini, Ubaldo Armato and Jun Wu
    Citation: Journal of Nanobiotechnology 2022 20:395
  30. Epithelial-mesenchymal transition (EMT), a differentiation process with aberrant changes of tumor cells, is identified as an initial and vital procedure for metastatic processes. Inflammation is a significant ...

    Authors: Tianze Jiang, Laozhi Xie, Songlei Zhou, Yipu Liu, Yukun Huang, Ni Mei, Fenfen Ma, Jingru Gong, Xiaoling Gao and Jun Chen
    Citation: Journal of Nanobiotechnology 2022 20:394
  31. High-quality point-of-care is critical for timely decision of disease diagnosis and healthcare management. In this regard, biosensors have revolutionized the field of rapid testing and screening, however, are ...

    Authors: Sabyasachi Dash, Tuhin Das, Paritosh Patel, Pritam Kumar Panda, Mrutyunjay Suar and Suresh K. Verma
    Citation: Journal of Nanobiotechnology 2022 20:393
  32. Injuries to the urethra can be caused by malformations, trauma, inflammation, or carcinoma, and reconstruction of the injured urethra is still a significant challenge in clinical urology. Implanting grafts for...

    Authors: Qinyuan Tan, Hanxiang Le, Chao Tang, Ming Zhang, Weijie Yang, Yazhao Hong and Xiaoqing Wang
    Citation: Journal of Nanobiotechnology 2022 20:392
  33. Cancer nanomedicines based on synthetic polypeptides have attracted much attention due to their superior biocompatibility and biodegradability, stimuli responsive capability through secondary conformation chan...

    Authors: Maliheh Hasannia, Khalil Abnous, Seyed Mohammad Taghdisi, Sirous Nekooei, Mohammad Ramezani and Mona Alibolandi
    Citation: Journal of Nanobiotechnology 2022 20:391
  34. Abundant glutathione (GSH) is a biological characteristic of lots of tumor cells. A growing number of studies are utilizing GSH depletion as an effective adjuvant therapy for tumor. However, due to the compens...

    Authors: Yang Gao, Yun Li, Hongmei Cao, Haixue Jia, Dianyu Wang, Chunhua Ren, Zhongyan Wang, Cuihong Yang and Jianfeng Liu
    Citation: Journal of Nanobiotechnology 2022 20:390
  35. Dysregulated mucosal immune responses and colonic fibrosis impose two formidable challenges for ulcerative colitis treatment. It indicates that monotherapy could not sufficiently deal with this complicated dis...

    Authors: Jiaxin Zhang, Ante Ou, Xueping Tang, Rong Wang, Yujuan Fan, Yuefei Fang, Yuge Zhao, Pengfei Zhao, Dongying Chen, Bing Wang and Yongzhuo Huang
    Citation: Journal of Nanobiotechnology 2022 20:389
  36. The anticancer treatment is largely affected by the microenvironment of the tumors, which not only resists the tumors to the thermo/chemo-therapy, but also promotes their growth and invasion. In this work, the...

    Authors: Ying Zhang, Jingyao Zhu, Zheng Zhang, Dannong He, Jun Zhu, Yunsheng Chen and Yixin Zhang
    Citation: Journal of Nanobiotechnology 2022 20:388
  37. The plant toxin ricin, especially its cytotoxic A chain (RTA), can be genetically engineered with targeting ligands to develop specific anti-cancer recombinant immunotoxins (RITs). Here, we used affibody molec...

    Authors: Seong Guk Park, Heeyeon Kim, Heejin Jun, Sun Young Choi, Eunhee Kim and Sebyung Kang
    Citation: Journal of Nanobiotechnology 2022 20:387
  38. The colonization of bacterial pathogens is a major concern in wound infection and becoming a public health issue. Herein, a core–shell structured Ag@MSN (silver core embedded with mesoporous silica, AM)-based ...

    Authors: Qiqi Liu, Ying Zhang, Jingkai Huang, Zhourui Xu, Xiang Li, Jingyu Yang, Haoqiang Huang, Shiqi Tang, Yujuan Chai, Jinbo Lin, Chengbin Yang, Jia Liu and Suxia Lin
    Citation: Journal of Nanobiotechnology 2022 20:386
  39. Exosomes are recognized as effective platforms for targeted delivery for their high physicochemical stability and biocompatibility. However, most of the exosomes are inevitably and rapidly cleared by mononucle...

    Authors: Zhuo Wan, Xueqi Gan, Ruiyan Mei, Jianbin Du, Wen Fan, Mengying Wei, Guodong Yang, Weiwei Qin, Zhuoli Zhu and Li Liu
    Citation: Journal of Nanobiotechnology 2022 20:385
  40. Melanoma is the most malignant skin tumor and is difficult to cure with the alternative treatments of chemotherapy, biotherapy, and immunotherapy. Our previous study showed that triptolide (TP) exhibited powerful...

    Authors: Yongwei Gu, Yue Du, Liangdi Jiang, Xiaomeng Tang, Aixue Li, Yunan Zhao, Yitian Lang, Xiaoyan Liu and Jiyong Liu
    Citation: Journal of Nanobiotechnology 2022 20:384
  41. Bioactive materials have been extensively developed for the adjuvant therapy of cancer. However, few materials can meet the requirements for the postoperative resection of hepatocellular carcinoma (HCC) due to...

    Authors: Sheng Chen, Yonghong Song, Xu Yan, Liang Dong, Yunjun Xu, Shouhu Xuan, Quan Shu, Baoqiang Cao, Jinlong Hu, Hanye Xing, Wenshu Wu, Zhengbao Zha and Yang Lu
    Citation: Journal of Nanobiotechnology 2022 20:381
  42. Innate immunity is the first line of defense against invading pathogens. Innate immune cells can recognize invading pathogens through recognizing pathogen-associated molecular patterns (PAMPs) via pattern reco...

    Authors: Chung-Nga Ko, Shaohong Zang, Yingtang Zhou, Zhangfeng Zhong and Chao Yang
    Citation: Journal of Nanobiotechnology 2022 20:380
  43. Disruption of the postsynaptic density protein-95 (PSD95)—neuronal nitric oxide synthase (nNOS) coupling is an effective way to treat ischemic stroke, however, it still faces some challenges, especially lack o...

    Authors: Yingying Ding, Yang Jin, Tao Peng, Yankun Gao, Yang Zang, Hongliang He, Fei Li, Yu Zhang, Hongjuan Zhang and Lina Chen
    Citation: Journal of Nanobiotechnology 2022 20:379
  44. Type 1 diabetes mellitus (T1DM) is an autoimmune disease mediated by autoreactive T cells and dominated by Th1 response polarization. Insulin replacement therapy faces great challenges to this autoimmune disea...

    Authors: Haoming Huang, Dian Hu, Zhuo Chen, Jiarong Xu, Rengui Xu, Yusheng Gong, Zhengming Fang, Ting Wang and Wei Chen
    Citation: Journal of Nanobiotechnology 2022 20:377
  45. Breast cancer is the leading cause of cancer-related deaths in women and remains a formidable therapeutic challenge. Mitochondria participate in a myriad of essential cellular processes, such as metabolism, an...

    Authors: Liwei Gu, Jiaxing Zhang, Dandan Liu, Jiayun Chen, Shuzhi Liu, Qing Peng, Ya Tian, Maobo Du, Junzhe Zhang, Wei Xiao, Shuo Shen and Jigang Wang
    Citation: Journal of Nanobiotechnology 2022 20:376

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