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  1. For certain human cancers, sperm associated antigen 5 (SPAG5) exerts important functions for their development and progression. However, whether RNA interference (RNAi) targeting SPAG5 has antitumor effects has n...

    Authors: Jianye Liu, Yi Zhang, Hongliang Zeng, Long Wang, Qun Zhang, Pei Wu, Xiaoming Liu, Hongyi Xie, Wei Xiang, Biao Liu, Jiahao Liu, Xuewen Liu, Jianfei Xie, Jin Tang, Zhi Long, Leye He…

    Citation: Journal of Nanobiotechnology 2021 19:189

    Content type: Research

    Published on:

  2. The toxicity and inefficient delivery of triptolide (TPL) in tumor therapy have greatly limited the clinical application. Thus, we fabricated a CD44-targeting and tumor microenvironment pH/redox-sensitive nano...

    Authors: Jinfeng Shi, Yali Ren, Jiaqi Ma, Xi Luo, Jiaxin Li, Yihan Wu, Huan Gu, Chaomei Fu, Zhixing Cao and Jinming Zhang

    Citation: Journal of Nanobiotechnology 2021 19:188

    Content type: Research

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  3. Ex vivo and in vivo detection and imaging of adenosine triphosphate (ATP) is critically important for the diagnosis and treatment of diseases, which still remains challenges up to present.

    Authors: Binbin Chu, Ajun Wang, Liang Cheng, Runzhi Chen, Huayi Shi, Bin Song, Fenglin Dong, Houyu Wang and Yao He

    Citation: Journal of Nanobiotechnology 2021 19:187

    Content type: Research

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  4. Many pathogens, including Yersinia pestis, cannot be consistently and reliably cultured from blood. New approaches are needed to facilitate the detection of proteins, nucleic acid and microorganisms in whole bloo...

    Authors: Alexandra N. Ii, Shih-Chao Lin, Benjamin Lepene, Weidong Zhou, Kylene Kehn-Hall and Monique L. van Hoek

    Citation: Journal of Nanobiotechnology 2021 19:186

    Content type: Research

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  5. Circulating tumor cells (CTCs) are the dominant factor leading to tumor metastasis. This study aims to investigate the effect of disparate sources of CTCs on the treatment and prognosis of patients with advanc...

    Authors: Yan Liu, Qiuying Li, Tingsong Chen, Tianhao Shen, Xufeng Zhang, Ping Song, Lantao Liu, Jianming Liu, Tinghui Jiang and Xiaofei Liang

    Citation: Journal of Nanobiotechnology 2021 19:185

    Content type: Research

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  6. Gestational trophoblastic tumors seriously endanger child productive needs and the health of women in childbearing age. Nanodrug-based therapy mediated by transporters provides a novel strategy for the treatme...

    Authors: Weidong Fei, Yunchun Zhao, Xiaodong Wu, Dongli Sun, Yao Yao, Fengmei Wang, Meng Zhang, Chaoqun Li, Jiale Qin and Caihong Zheng

    Citation: Journal of Nanobiotechnology 2021 19:184

    Content type: Research

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  7. Acid-tolerant enteric pathogens can evade small intestinal acid barriers, colonize and infect the intestinal tract. However, broad-spectrum antibiotics are not the best therapeutic strategy because of the disr...

    Authors: Qiuke Li, Jinze Li, Weikang Yu, Zhihua Wang, Jiawei Li, Xingjun Feng, Jiajun Wang and Anshan Shan

    Citation: Journal of Nanobiotechnology 2021 19:183

    Content type: Research

    Published on:

  8. Photodynamic therapy (PDT) may elicit antitumor immune response in addition to killing cancer cells. However, PDT as a monotherapy often fails to induce a strong immunity. Immune checkpoint inhibitors, which s...

    Authors: Xueyuan Yang, Weizhong Zhang, Wen Jiang, Anil Kumar, Shiyi Zhou, Zhengwei Cao, Shuyue Zhan, Wei Yang, Rui Liu, Yong Teng and Jin Xie

    Citation: Journal of Nanobiotechnology 2021 19:182

    Content type: Research

    Published on:

  9. Triple-negative breast cancer (TNBC) is a highly aggressive malignant disease with a high rate of recurrence and metastasis, few effective treatment options and poor prognosis. Here, we designed and constructe...

    Authors: Peiqi Zhao, Yuanlin Xu, Wei Ji, Shiyong Zhou, Lanfang Li, Lihua Qiu, Zhengzi Qian, Xianhuo Wang and Huilai Zhang

    Citation: Journal of Nanobiotechnology 2021 19:181

    Content type: Research

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  10. Ferritin, the natural iron storage protein complex, self-assembles into a uniform cage-like structure. Human H-ferritin (HFn) has been shown to transverse the blood–brain barrier (BBB) by binding to transferri...

    Authors: Chiun-Wei Huang, Chia-Pao Chuang, Yan-Jun Chen, Hsu-Yuan Wang, Jia-Jia Lin, Chiung-Yin Huang, Kuo-Chen Wei and Feng-Ting Huang

    Citation: Journal of Nanobiotechnology 2021 19:180

    Content type: Research

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  11. Non-Hodgkin’s lymphoma (NHL) is a malignant disease of lymphoid tissue. At present, chemotherapy is still the main method for the treatment of NHL. R-CHOP can significantly improve the survival rate of patient...

    Authors: Qiangqiang Zhao, Duanfeng Jiang, Xiaoying Sun, Qiuyu Mo, Shaobin Chen, Wansong Chen, Rong Gui and Xianjun Ma

    Citation: Journal of Nanobiotechnology 2021 19:179

    Content type: Research

    Published on:

  12. One of the most common complications in diabetic nephropathy is generation of high levels of ROS which can be regulated by herbal antioxidants. However, polyphenols like calycosin, the bioactive compound of Radix...

    Authors: Chunrong Huang, Lian-Fang Xue, Bo Hu, Huan-Huan Liu, Si-Bo Huang, Suliman Khan and Yu Meng

    Citation: Journal of Nanobiotechnology 2021 19:178

    Content type: Research

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  13. Ras activation is a frequent event in hepatocellular carcinoma (HCC). Combining a RAS inhibitor with traditional clinical therapeutics might be hampered by a variety of side effects, thus hindering further cli...

    Authors: Bolin Wu, Yanchi Yuan, Jiayin Liu, Haitao Shang, Jing Dong, Xitian Liang, Dongxu Wang, Yichi Chen, Chunyue Wang, Yang Zhou, Hui Jing and Wen Cheng

    Citation: Journal of Nanobiotechnology 2021 19:177

    Content type: Research

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  14. An amendment to this paper has been published and can be accessed via the original article.

    Authors: Bin Yi, Tian Wu, Nan Zhu, Yao Huang, Xiaoyu Yang, Lei Yuan, Yingjun Wu, Xiaofei Liang and Xiaoqing Jiang

    Citation: Journal of Nanobiotechnology 2021 19:176

    Content type: Correction

    Published on:

    The original article was published in Journal of Nanobiotechnology 2021 19:74

  15. Adoptive T cell transfer-based immunotherapy yields unsatisfactory results in the treatment of solid tumors, partially owing to limited tumor infiltration and the immunosuppressive microenvironment in solid tu...

    Authors: Dehua Lu, Yanpu Wang, Ting Zhang, Feng Wang, Kui Li, Shixin Zhou, Hua Zhu, Zhi Yang and Zhaofei Liu

    Citation: Journal of Nanobiotechnology 2021 19:175

    Content type: Research

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  16. Silicon dioxide nanoparticles (SiO2NPs) are widely used as additive in the food industry with controversial health risk. Gut microbiota is a new and hot topic in the field of nanotoxicity. It also contributes a n...

    Authors: Jun Diao, Yinyin Xia, Xuejun Jiang, Jingfu Qiu, Shuqun Cheng, Junhao Su, Xinhao Duan, Min Gao, Xia Qin, Jun Zhang, Jingchuan Fan, Zhen Zou and Chengzhi Chen

    Citation: Journal of Nanobiotechnology 2021 19:174

    Content type: Research

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  17. The worldwide pandemic of COVID-19 remains a serious public health menace as the lack of efficacious treatments. Cytokine storm syndrome (CSS) characterized with elevated inflammation and multi-organs failure ...

    Authors: Qingqin Tan, Lingjie He, Xiaojun Meng, Wei Wang, Hudan Pan, Weiguo Yin, Tianchuan Zhu, Xi Huang and Hong Shan

    Citation: Journal of Nanobiotechnology 2021 19:173

    Content type: Research

    Published on:

  18. In recent years, the use of ferritins as nano-vehicles for drug delivery is taking center stage. Compared to other similar nanocarriers, Archaeoglobus fulgidus ferritin is particularly interesting due to its uniq...

    Authors: Federica Palombarini, Silvia Masciarelli, Alessio Incocciati, Francesca Liccardo, Elisa Di Fabio, Antonia Iazzetti, Giancarlo Fabrizi, Francesco Fazi, Alberto Macone, Alessandra Bonamore and Alberto Boffi

    Citation: Journal of Nanobiotechnology 2021 19:172

    Content type: Research

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  19. Nasopharyngeal carcinoma (NPC) is a type of head and neck malignant tumor with a high incidence in specific regional distribution, and its traditional therapies face some challenges. It has become an urgent ne...

    Authors: Qinmin Liu, Lijuan Liu, Chunwei Mo, Xiao Zhou, Dongming Chen, Yu He, Hailu He, Wei Kang, Yongfeng Zhao and Guanqiao Jin

    Citation: Journal of Nanobiotechnology 2021 19:171

    Content type: Research

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  20. Inflammatory osteolysis after total joint replacement (TJR) may cause implant failure, periprosthetic fractures, and be a severe threat to global public health. Our previous studies demonstrated that melatonin...

    Authors: Yanglin Wu, Fan He, Chenhui Zhang, Qin Zhang, Xinlin Su, Xu Zhu, Ang Liu, Weidong Shi, Weifeng Lin, Zhongqin Jin, Huilin Yang and Jun Lin

    Citation: Journal of Nanobiotechnology 2021 19:170

    Content type: Research

    Published on:

  21. Exosomes are extracellular vesicles of nano-structures and represent an emerging nano-scale acellular therapy in recent years. Tendon regeneration is a sophisticated process in the field of microsurgery due to...

    Authors: Zhixiao Yao, Juehong Li, Hao Xiong, Haomin Cui, Jiexin Ning, Shikun Wang, Xingyu Ouyang, Yun Qian and Cunyi Fan

    Citation: Journal of Nanobiotechnology 2021 19:169

    Content type: Research

    Published on:

  22. Lipid liquid crystalline nanoparticles (LLCNPs) emerge as a suitable system for drug and contrast agent delivery. In this regard due to their unique properties, they offer a solubility of a variety of active p...

    Authors: Jakub Jagielski, Łucja Przysiecka, Dorota Flak, Magdalena Diak, Zuzanna Pietralik-Molińska, Maciej Kozak, Stefan Jurga and Grzegorz Nowaczyk

    Citation: Journal of Nanobiotechnology 2021 19:168

    Content type: Research

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  23. Liposomes are widely used as drug delivery carriers and as cell model systems. Here, we measure the dielectric properties of individual liposomes adsorbed on a metal electrode by in-liquid scanning dielectric ...

    Authors: Martina Di Muzio, Ruben Millan-Solsona, Aurora Dols-Perez, Jordi H. Borrell, Laura Fumagalli and Gabriel Gomila

    Citation: Journal of Nanobiotechnology 2021 19:167

    Content type: Methodology

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  24. Heavy metal pollution has become more and more serious with industrial development and resource exploitation. Because heavy metal ions are difficult to be biodegraded, they accumulate in the human body and cau...

    Authors: Wenfei Guo, Chuanxiang Zhang, Tingting Ma, Xueying Liu, Zhu Chen, Song Li and Yan Deng

    Citation: Journal of Nanobiotechnology 2021 19:166

    Content type: Review

    Published on:

  25. Overexpressed vascular endothelial growth factor A (VEGFA) and phosphorylated signal transducer and activator of transcription 3 (P-STAT3) cause unrestricted tumor growth and angiogenesis of breast cancer (BRC...

    Authors: Ke Gong, Juyang Jiao, Chaoqun Xu, Yang Dong, Dongxiao Li, Di He, De Zhao, Jian Yu, Ying Sun, Wei Zhang, Min Bai and Yourong Duan

    Citation: Journal of Nanobiotechnology 2021 19:165

    Content type: Research

    Published on:

  26. Chrysomycin A (CA) has been reported as numerous excellent biological activities, such as antineoplastic and antibacterial. Though, poor solubility of CA limited its application in medical field. Due to good a...

    Authors: Zhuomin Xu, Shanshan Zheng, Xin Gao, Yulu Hong, Yue Cai, Qiuqin Zhang, Jiani Xiang, Dehui Xie, Fuxing Song, Huawei Zhang, Hong Wang and Xuanrong Sun

    Citation: Journal of Nanobiotechnology 2021 19:164

    Content type: Research

    Published on:

  27. Ascorbic acid (AA) is a micronutrient essential for the mechanisms of reproduction, growth, and defense in fish. However, the biosynthesis of this micronutrient does not occur in fish, so it must be supplied w...

    Authors: Angélica I. S. Luis, Estefânia V. R. Campos, Jhones L. Oliveira, José Henrique Vallim, Patrícia L. F. Proença, Rodrigo F. Castanha, Vera L. S. S. de Castro and Leonardo F. Fraceto

    Citation: Journal of Nanobiotechnology 2021 19:163

    Content type: Research

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  28. Copper oxide nanoparticles (CuONPs) are one of the widely used metal nanoparticles in the industrial and commercial fields. Autophagy is an intracellular degradation system that delivers cytoplasmic constituen...

    Authors: Junting Xiao, Baijie Tu, Xin Zhou, Xuejun Jiang, Ge Xu, Jun Zhang, Xia Qin, Golamaully Sumayyah, Jingchuan Fan, Bin Wang, Chengzhi Chen and Zhen Zou

    Citation: Journal of Nanobiotechnology 2021 19:162

    Content type: Research

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  29. As one typical cardiovascular disease, atherosclerosis severely endanger people’ life and cause burden to people health and mentality. It has been extensively accepted that oxidative stress and inflammation cl...

    Authors: Yan Zhang, Yifei Yin, Wei Zhang, Hongyan Li, Taixia Wang, Haohao Yin, Liping Sun, Chunxia Su, Kun Zhang and Huixiong Xu

    Citation: Journal of Nanobiotechnology 2021 19:161

    Content type: Research

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  30. Photodynamic therapy (PDT) is a non-invasive or minimally-invasive treatment which applies photosensitizers (PSs) to create reactive oxygen species (ROS) exposed to light trigger to destroy cancer cells. PDT c...

    Authors: Zhaoyuan Liu, Zhongjian Xie, Wenting Li, Xinqiang Wu, Xiaofeng Jiang, Guanhua Li, Liangqi Cao, Dawei Zhang, Qiwen Wang, Ping Xue and Han Zhang

    Citation: Journal of Nanobiotechnology 2021 19:160

    Content type: Review

    Published on:

  32. The appearance of resistance against new treatments and the fact that HIV-1 can infect various cell types and develop reservoirs and sanctuaries makes it necessary to develop new therapeutic approaches to over...

    Authors: E. Royo-Rubio, I. Rodríguez-Izquierdo, M. Moreno-Domene, T. Lozano-Cruz, F. J. de la Mata, R. Gómez, M. A. Muñoz-Fernández and J. L. Jiménez

    Citation: Journal of Nanobiotechnology 2021 19:158

    Content type: Research

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  33. Smart nanoscale drug delivery systems that target acidic tumor microenvironments (TME) could offer controlled release of drugs and modulate the hypoxic TME to enhance cancer therapy. The majority of previously...

    Authors: Zhi-hang Zhou, Si-yuan Liang, Tong-chao Zhao, Xu-zhuo Chen, Xian-kun Cao, Ming Qi, Ying-ying Huang, Wu-tong Ju, Meng Yang, Dong-wang Zhu, Yi-chuan Pang and Lai-ping Zhong

    Citation: Journal of Nanobiotechnology 2021 19:157

    Content type: Research

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  34. Despite the dramatic advances in modern medicine, efficient therapeutic measures for renal fibrosis remain limited. Celastrol (CLT) is effective in treating renal fibrosis in rat models, while causing severe s...

    Authors: Xuan Zhang, Qian Chen, Liyuan Zhang, Haiping Zheng, Chunjie Lin, Qunfang Yang, Tao Liu, Haigang Zhang, Xiaohong Chen, Lei Ren and Wenjun Shan

    Citation: Journal of Nanobiotechnology 2021 19:156

    Content type: Research

    Published on:

  35. Theranostic nanoparticles (NPs) have achieved rapid development owing to their capacity for personalized multimodal diagnostic imaging and antitumor therapy. However, the efficient delivery and bulk accumulati...

    Authors: Qiaolin Wei, Jian He, Shuaifei Wang, Shiyuan Hua, Yuchen Qi, Fangyuan Li, Daishun Ling and Min Zhou

    Citation: Journal of Nanobiotechnology 2021 19:155

    Content type: Research

    Published on:

  36. Porphyrin-lipids are versatile building blocks that enable cancer theranostics and have been applied to create several multimodal nanoparticle platforms, including liposome-like porphysome (aqueous-core), porp...

    Authors: Enling Chang, Jiachuan Bu, Lili Ding, Jenny W. H. Lou, Michael S. Valic, Miffy. H. Y. Cheng, Véronique Rosilio, Juan Chen and Gang Zheng

    Citation: Journal of Nanobiotechnology 2021 19:154

    Content type: Research

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  37. Salinity is a worldwide factor limiting the agricultural production. Cotton is an important cash crop; however, its yield and product quality are negatively affected by soil salinity. Use of nanomaterials such...

    Authors: Jiahao Liu, Guangjing Li, Linlin Chen, Jiangjiang Gu, Honghong Wu and Zhaohu Li

    Citation: Journal of Nanobiotechnology 2021 19:153

    Content type: Research

    Published on:

  38. Mitochondria play a role in the occurrence, development, drug resistance, metastasis, and other functions of cancer and thus are a drug target. An acid-activated mitochondria-targeting drug nanocarrier with re...

    Authors: He Wang, Wenwen Shi, Danning Zeng, Qiudi Huang, Jiacui Xie, Huaying Wen, Jinfang Li, Xiyong Yu, Linghao Qin and Yi Zhou

    Citation: Journal of Nanobiotechnology 2021 19:152

    Content type: Research

    Published on:

  39. Colon cancer contributes to high mortality rates as the result of incomplete resection in tumor surgery. Multimodal imaging can provide preoperative evaluation and intraoperative image-guiding. As biocompatibl...

    Authors: Boping Jing, Ruijie Qian, Dawei Jiang, Yongkang Gai, Zhen Liu, Feng Guo, Sen Ren, Yu Gao, Xiaoli Lan and Rui An

    Citation: Journal of Nanobiotechnology 2021 19:151

    Content type: Research

    Published on:

  40. Enhanced angiogenesis can promote diabetic wound healing. Mesenchymal stem cells (MSCs)-derived exosomes, which are cell-free therapeutics, are promising candidates for the treatment of diabetic wound healing....

    Authors: Yiqiang Hu, Ranyang Tao, Lang Chen, Yuan Xiong, Hang Xue, Liangcong Hu, Chenchen Yan, Xudong Xie, Ze Lin, Adriana C. Panayi, Bobin Mi and Guohui Liu

    Citation: Journal of Nanobiotechnology 2021 19:150

    Content type: Research

    Published on:

  41. Photodynamic therapy (PDT) is a clinically implemented modality to combat malignant tumor, while its efficacy is largely limited by several resistance factors from tumor microenvironment (TME), such as hypoxia...

    Authors: Peng Liu, Yanbin Zhou, Xinyi Shi, Yu Yuan, Ying Peng, Surong Hua, Qiange Luo, Jinsong Ding, Yong Li and Wenhu Zhou

    Citation: Journal of Nanobiotechnology 2021 19:149

    Content type: Research

    Published on:

  42. The application of extracellular vesicles (EVs) derived from mesenchymal stem cells (MSCs) requires customized materials to target disease or cell damage. We hypothesized that EVs exert different inflammatory ...

    Authors: Dong Jun Park, Jeong-Eun Park, Tae Hoon Kong and Young Joon Seo

    Citation: Journal of Nanobiotechnology 2021 19:148

    Content type: Research

    Published on:

  43. Triple negative breast cancer (TNBC) is an aggressive tumor with extremely high mortality that results from its lack of effective therapeutic targets. As an adhesion molecule related to tumorigenesis and tumor...

    Authors: Yinan Ding, Rui Yang, Weiping Yu, Chunmei Hu, Zhiyuan Zhang, Dongfang Liu, Yanli An, Xihui Wang, Chen He, Peidang Liu, Qiusha Tang and Daozhen Chen

    Citation: Journal of Nanobiotechnology 2021 19:147

    Content type: Research

    Published on:

  44. Paclitaxel (PTX) has been suggested to be a promising front-line drug for gastric cancer (GC), while P-glycoprotein (P-gp) could lead to drug resistance by pumping PTX out of GC cells. Consequently, it might b...

    Authors: Weihong Guo, Zhian Chen, Xiaoli Feng, Guodong Shen, Huilin Huang, Yanrui Liang, Bingxia Zhao, Guoxin Li and Yanfeng Hu

    Citation: Journal of Nanobiotechnology 2021 19:146

    Content type: Research

    Published on:

  45. The indiscriminate use of herbicides in agriculture contributes to soil and water pollution, with important endangering consequences on the ecosystems. Among the available analytical systems, algal biosensors ...

    Authors: Amina Antonacci, Raouia Attaallah, Fabiana Arduini, Aziz Amine, Maria Teresa Giardi and Viviana Scognamiglio

    Citation: Journal of Nanobiotechnology 2021 19:145

    Content type: Research

    Published on:

  46. Breast cancer (BC) is the most frequently diagnosed cancer with a low survival rate and one of the major causes of cancer-related death. Methotrexate (MTX) is an anti-tumor drug used in the treatment of BC. Po...

    Authors: Wen Li, Zhiwen Cao, Liuchunyang Yu, Qingcai Huang, Dongjie Zhu, Cheng Lu, Aiping Lu and Yuanyan Liu

    Citation: Journal of Nanobiotechnology 2021 19:143

    Content type: Research

    Published on:

  47. Therapeutic tumor vaccine (TTV) that induces tumor-specific immunity has enormous potentials in tumor treatment, but high heterogeneity and poor immunogenicity of tumor seriously impair its clinical efficacy. ...

    Authors: Lirong Zhang, Jingjing Zhang, Lixia Xu, Zijian Zhuang, Jingjin Liu, Suwan Liu, Yunchao Wu, Aihua Gong, Miaomiao Zhang and Fengyi Du

    Citation: Journal of Nanobiotechnology 2021 19:142

    Content type: Research

    Published on:

  48. The incidence of ischemic stroke in the context of vascular disease is high, and the expression of growth-associated protein-43 (GAP43) increases when neurons are damaged or stimulated, especially in a rat mod...

    Authors: Lin Guo, Zhixuan Huang, Lijuan Huang, Jia Liang, Peng Wang, Liang Zhao and Yijie Shi

    Citation: Journal of Nanobiotechnology 2021 19:141

    Content type: Research

    Published on:

  49. Synergistic chemo-photodynamic therapy has garnered attention in the field of cancer treatment. Here, a pH cascade-responsive micellar nanoplatform with nucleus-targeted ability, for effective synergistic chem...

    Authors: Fan Li, Yan Liang, Miaochen Wang, Xing Xu, Fen Zhao, Xu Wang, Yong Sun and Wantao Chen

    Citation: Journal of Nanobiotechnology 2021 19:140

    Content type: Research

    Published on:

  50. An amendment to this paper has been published and can be accessed via the original article.

    Authors: Yang Wang, Binxi Li, Hao Xu, Shulin Du, Ting Liu, Jingyan Ren, Jiayi Zhang, Hao Zhang, Yi Liu and Laijin Lu

    Citation: Journal of Nanobiotechnology 2021 19:139

    Content type: Correction

    Published on:

    The original article was published in Journal of Nanobiotechnology 2020 18:64

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