Table 5 Description of experimental groups
From: Antitumor activity of photodynamic therapy performed with nanospheres containing zinc-phthalocyanine
Group | Treatment | Treatment abbreviation | Experimental design | |||
|---|---|---|---|---|---|---|
Tumor | ZnPcS4-AN | Laser | Doxorubicin | |||
1 | Filtered water and no tumor implantation (negative control) | NC | - | - | - | - |
2 | Tumor inoculation and no treatment (control tumor) | CT | + | - | - | - |
3 | Intratumoral injection of 20 μL (0.5 mM) ZnPcS4-AN | ZnPc | + | + | - | - |
4 | Tumor irradiated only with light from a laser setup working at 670 nm, in a total dose of 100 J/cm2 | LS | + | - | + | - |
5 | Intratumoral injection of 0.5 mM ZnPcS4-AN followed by light activation considering the same treatment as described for group 4 | PDT | + | + | + | - |
6 | Intratumoral injection of 20 mg/m2 doxorubicin | Dox | + | - | - | + |
7 | Intratumoral injection of 0.5 mM ZnPcS4-AN and 20 mg/m2 Dox | ZnPc/Dox | + | + | - | + |
8 | Intratumoral injection of 20 mg/m2 Dox and the same treatment as group 4 | Dox/LS | + | - | + | + |
9 | Intratumoral injection of 0.5 mM ZnPcS4-AN and 20 mg/m2 Dox and the same treatment as group 5 | Dox/PDT | + | + | + | + |