Figure 3
Short name: Coronal T 2 -weighted images, DCE-MRI images and RCE maps of two mice bearing a GL261 glioma. Detailed legend: From left to right, representative coronal T2-weighted images, DCE-MRI images (T1-weighted reference prior to contrast (T1-ref) and at the maximum contrast enhancement point (T1-max)), and RCE maps of two mice bearing a GL261 glioma. One animal was studied with gadoterate meglumine (top), and the other with GNP (E_2) (bottom). T1-ref images were acquired before injecting the contrast agent bolus while T1-max images correspond to the point of maximum contrast enhancement after gadoterate meglumine or GNP administration (see Figure 4). Colour coded bars on top of RCE provide intensity range shown in figures. Black pixels correspond to instances with values above or below the user-established %RCE postprocessing limits as described in methods.