Entrapment of an EGFR inhibitor into nanostructured lipid carriers (NLC) improves its antitumor activity against human hepatocarcinoma cells

Table 1 Mean size, PDI in different aqueous media, Loading Capacity (LC%) and Entrapment Efficiency (EE%) values of empty and tyrphostin AG-1478 -loaded NLC

Sample	H₂O		NaCl 0.9 wt%		PBS pH 7.4
	Size (nm)	PDI	Size (nm)	PDI	Size (nm)	PDI	LC (wt%)	EE (wt%)
Empty NLC-A	139.7	0.38	146.2	0.43	122.2	0.59	----	----
Drug-loaded NLC-A	176.2	0.41	207.2	0.90	145.6	0.79	2.8	28.0
Empty NLC-B	62.6	0.46	120.3	0.75	106.6	0.76	----	-----
Drug-loaded NLC-B	80.1	0.49	108.4	0.49	180.1	0.58	1.7	17.0
Empty NLC-C	175.9	0.34	129.2	0.33	117.1	0.41	----	----
Drug-loaded NLC-C	209.7	0.46	203.7	0.22	248.1	0.29	24.0	70.0
Empty NLC-D	185.5	0.29	125.6	0.28	143.8	0.25	----	----
Drug-loaded NLC-D	189.3	0.42	248.1	0.65	181.5	0.52	24.0	70.0

ISSN: 1477-3155