Figure 3

Adsorption of carboxy methylcellulose onto amphotericin B- cationic lipid assemblies preserves monomeric state of the drug at the edges of cationic bilayer fragments. Optical spectra of AmB in: 1:1 DMSO: methanol (best organic solvent mixture) (A); water (B); DODAB BF (C) or DODAB BF/AmB/CMC complexes (D). Final DODAB, AmB and/or CMC concentration are 1 mM, 0.005 mM and 1 mg.mL-1, respectively.