Figure 2

Highly uniform PLGA nanoparticles are fabricated by the Fluidic NanoPrecipitation System (FNPS). Scanning Electron Microscopy (SEM) images of PLGA nanoparticles fabricated by the (A) FNPS, or the (B) conventional nanoprecipitation method. (C) Diameters of the particles were measured by using ImageJ. For each sample, the mean diameter was calculated based on the measurements of 200 randomly chosen particles. White bars indicate the distribution of diameters observed for PLGA nanoparticles fabricated by FNPS (average diameter 148 ± 14 nm). Black bars indicate the distribution of diameters for PLGA nanoparticles fabricated by the traditional nanoprecipitation method (average diameter 211 ± 70 nm). Samples were imaged without prior filtration.