Figure 5
Distribution of interbeat intervals of two cardiomyocytes coupled through a cardiac fibroblast, and changes in the mean beating rhythm fluctuation before and after synchronization. (a)(d) Distribution of interbeat intervals before synchronization. Blue and red bars show the frequency (%) of each interbeat interval for two cardiomyocytes, and blue and red arrowheads indicate the mean values for each. (b)(e) Distribution of interbeat intervals after synchronization. Blue and red arrowheads indicate the before-synchronization mean values for the same two cardiomyocytes whose data are shown in (a) and (d) respectively, and the black arrowheads show the mean value for the synchronized cardiomyocytes. (c)(f) Beating rhythm fluctuation (coefficient of variation, CV) in 1-min intervals before and after synchronization. Blue filled circles and red filled squares show mean values for the same two cardiomyocytes whose data are shown in (a) and (d) respectively. Results for two kind pairs are shown in (a)-(c) for fluctuation CV decrease and (d)-(f) for those increase. In detail, see Table 2.