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Table 1 Parameter of field potential recordings of cardiomyocytes circuit on ring-type electrodes at the administration of Astemizole

From: On-chip constructive cell-network study (II): on-chip quasi-in vivo cardiac toxicity assay for ventricular tachycardia/fibrillation measurement using ring-shaped closed circuit microelectrode with lined-up cardiomyocyte cell network

Sample

Beating frequency

ST

 

Mean ± SD (Hz)

Mean ± SD (ms)

STV (ms)

 

Before

10 nM

100 nM

1 μM†

 

Before

10 nM

100 nM

1 μM†

Before

10 nM

100 nM

1 μM†

1

0.53 ± 0.04

0.47 ± 0.06

0.54 ± 0.06

0.29 ± 0.09

a

408 ± 10

427 ± 9

509 ± 23

446 ± 12

7.8

6.1

4.6

9.2

2

0.5 ± 0.05

0.45 ± 0.05

0.47 ± 0.05

0.68 ± 0.26

a

403 ± 5

425 ± 7

481 ± 12

473 ± 49

3.4

3.1

3.3

16.9

3

0.63 ± 0.09

0.54 ± 0.05

0.52 ± 0.08

0.47 ± 0.13

a

364 ± 6

386 ± 5

420 ± 7

441 ± 27

3.0

2.7

3.6

7.7

4

0.65 ± 0.06

0.59 ± 0.05

0.56 ± 0.05

0.41 ± 0.09

a

445 ± 9

491 ± 14

580 ± 27

423 ± 26

2.9

3.5

4.6

21.7

5

0.54 ± 0.11

0.38 ± 0.1

0.36 ± 0.06

0.28 ± 0.12

b

311 ± 6

337 ± 4

356 ± 4

410 ± 36

1.9

1.7

2.2

5.9

6

0.58 ± 0.06

0.52 ± 0.04

0.52 ± 0.06

0.58 ± 0.22

a

425 ± 7

455 ± 10

497 ± 7

526 ± 19

3.6

3.6

4.0

11.0

7

0.53 ± 0.04

0.47 ± 0.06

0.54 ± 0.06

0.29 ± 0.09

a

371 ± 8

402 ± 6

428 ± 4

435 ± 54

3.0

3.0

2.6

17.1

Mean

0.57

0.49

0.50

0.48

 

390

418

467

451

3.7

3.4

3.5

12.8

SD

0.05

0.07

0.07

0.16

 

45

49

73

38

1.9

1.3

0.9

5.8

t-tset

 

***

*

   

***

***

**

   

**

  1. a: Fibrillation after abnormal beating, b: Abnormal beating, †: Calculation from FP recordings just before abnormal beating.
  2. *: p < 0.05, **: p < 0.01, ***: P < 0.005, compareed to control in paired t-test.
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Journal of Nanobiotechnology

ISSN: 1477-3155

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