Figure 2

Drug release and cellular uptake study. (a) In vitro release study of DOX from GNP and EGNP. The release study was performed in phosphate buffered saline (pH 7.4) at 37 °C. The samples were collected at specified time points for up to 48 h and analysed by spectrophotometer. (b) Cellular uptake efficiency of GNP and EGNP in A549 and H226 cancer cells. Cells were incubated with 20 ?g/ml (DOX equivalent) for 30 and 120 min and analysed using HPLC method.*p < 0.05 is the statistical difference between EGNP and GNP.