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Table 1 Phantom and animal tests in this study

From: Dual-imaging model of SQUID biosusceptometry for locating tumors targeted using magnetic nanoparticles

Test type Test context
Phantom test • Anti-AFP reagent:
0.25 g in volume and 0.3, 0.2, 0.1, 0.01, 0.005 emu/g in concentration.
• Phantoms:
Micro test tubes were filled with anti-AFP reagent.
• Imaging:
The fused images composed of the magnetic image for the spatial distribution of anti-AFP MNPs and the optic image of micro test tubes.
Animal tests • Dose of Anti-AFP reagent:
0.9 g in volume and 0.3 emu/g in concentration.
• Tumor rats:
Liver tumors were implanted on backs for 2 rats and in livers for 3 rats, separately.
Anti-AFP reagents were intravenously injected through tail veins.
• Imaging:
The 2 tumor rats with back tumors were imaged in a prone position by using the dual-model SSB at 0 h.
The 3 tumor rats implanted with liver tumors were imaged in a supine position at 0 h, 24 h, and with their bellies opened at 24.5 h.
Both the stacked block and separated lobe livers of the 3 tumor rats implanted with liver tumors were magnetically examined ex vivo.
• Tissue stain:
After identifying the red-spot and no-spot regions in separated lobe livers by this dual-model SSB, small pieces of liver tissue in both regions for HE stain and AFP stain were performed.