Figure 1

Schematic representation of MNP-CSA-13 synthesis. The structures of ceragenin CSA-13 (panel A) and APTMS coated magnetic nanoparticles (panel B). The overall surface modification procedures: In the first step bare MNPs were coated with an aminosilane layer (APTMS), then aminosilane-coated MNPs were reacted with gluteraldehyde, a process resulting in the formation of terminal aldehyde groups able to interact with ceragenin CSA-13 through imine bond formation (panel C). Final structure of MNPs functionalized with CSA-13 (panel D).