Figure 7

Biocompatibility and antibacterial activity of MNP-CSA-13 in different body fluids. Hemoglobin release from human red blood cells (RBCs) after CSA-13 (white squares), MNP (white circles) and MNP-CSA-13 (black circles) addition (panel A). Antibacterial activity of MNP-CSA-13 against Pseudomonas aeruginosa Xen 5 in different human body fluids assessed using chemiluminescence measurement (panel B). In each condition the white column indicates luminescence of control samples. The black column indicates the luminescence signal after free ceragenin CSA-13 (100 μg/ml) treatment. The gray column indicates luminescence signal after addition of MNPs (100 μg/ml). Light gray column show luminescence signal after addition of MNP-CSA-13. Results represent mean ± SD, n = 3; * statistical significance compared to untreated control, ^ compared to bacteria treated with CSA-13 (p ≤ 0.05).