Fig. 1

TEM images of ultrathin sections of cells. Untreated cells showed no abnormalities (a), whereas cells treated with silver nanoparticles showed large endosomes near the cell membrane with many nanoparticles inside (b). Electron micrographs showing lysosomes with nanoparticles inside (thick arrows) and scattered in cytoplasm (open arrow). Diamond arrow shows the presence of the nanoparticle in the nucleus (c). Magnified images of nanogroups showed that the cluster is composed of individual nanoparticles rather than clumps (d). Image shows endosomes in cytosol that are lodged in the nuclear membrane invaginations (e) and the presence of nanoparticles in mitochondria and on the nuclear membrane (f) (reproduced from ref. Asharani et al. [14]. by permission of American Chemical Society)