Fig. 1

Amino acid sequence and three-dimensional model of peptide building block, pentamer-trimer complex, and mini-nanoparticle. a Amino acid sequence from the tryptophan zipper [PDB:1T8Z] and a de novo designed trimeric coiled-coil peptide [PDB:1HQJ] aligned with the sequence of the channel-forming domain of colicin E1 [PDB:2I88]. A parent sequence T2I88 is shown below that has been followed to build the initial model of the mini-nanoparticle peptide. Computational model of the starting construct (peptide 1) (b), neighboring pentamer-trimer complex (c), and a mini-nanoparticle (d) were built using the initial model of the peptide