Fig. 4

X-ray micrographs show leakage of AuNPs out of vessels. X-ray micrographs show bare AuNPs leaking out of vessels in the proximity of brain tumors. a The projection X-ray images at two different magnifications of a U87 mouse brain tumor with bare AuNPs perfusion show the whole brain vasculature, b patchwork of TXM images; c, d individual TXM projection images taken at different angles, corresponding to the light-grey rectangle in (b); e, f 3D tomographic reconstructed images, corresponding to the (c, d) images; g, h tomographic reconstructed single-slice images of (e, f). The yellow arrowheads mark bare AuNPs leaking out of tumor vessels. The white arrows mark the nuclei of endothelial cells