Table 3 Chronic toxicity of DS-PPF-NPs in different concentration (control, 0.75, 1.5, 3 and 6 mg/kg equivalent of disulfiram) on hematological markers in mice
Parameter | Groups | ||||
|---|---|---|---|---|---|
Control | DS-PPF-NPs (0.75 mg/kg) | DS-PPF-NPs (1.5 mg/kg) | DS-PPF-NPs (3 mg/kg) | DS-PPF-NPs (6 mg/kg) | |
Animal weight (g) | 23.3 ± 2.1 | 24.3 ± 2.5 | 22.1 ± 1.8 | 23.4 ± 1.2 | 20.2 ± 2.4 |
Urea (mg/dL) | 66.7 ± 2.6 | 73.3 ± 14.4 | 75.0 ± 13.5 | 76.3 ± 10.3 | 75.0 ± 0.0 |
Cr (mg/dL) | 0.5 ± 0.0 | 0.5 ± 0.0 | 0.5 ± 0.0 | 0.5 ± 0.0 | 0.5 ± 0.0 |
ALP (U/L) | 505.0 ± 142.0 | 468.3 ± 93.2 | 457.5 ± 47.9 | 452.5 ± 128.5 | 437.0 ± 70.8 |
SGOT (U/L) | 497.5 ± 101.0 | 500.0 ± 161.7 | 490.0 ± 0.0 | 505.0 ± 86.6 | 418.3 ± 2.6 |
SGPT (U/L) | 68.8 ± 23.4 | 70.0 ± 30.9 | 81.7 ± 11.3 | 76.7 ± 20.7 | 60.0 ± 11.5 |
D. BIL (mg/dL) | 0.6 ± 0.1 | 0.5 ± 0.0 | 0.5 ± 0.0 | 0.4 ± 0.1 | 0.5 ± 0.2 |
ALB (mg/dL) | 2.4 ± 0.2 | 2.4 ± 0.4 | 2.3 ± 0.3 | 2.3 ± 0.3 | 2.9 ± 0.6 |
Total protein (mg/dL) | 6.3 ± 1.8 | 5.3 ± 0.3 | 5.9 ± 0.6 | 5.5 ± 0.7 | 6.0 ± 1.2 |
Glucose (mg/dL) | 220.0 ± 57.7 | 215.0 ± 85.6 | 197.5 ± 31.8 | 233.3 ± 6.8 | 215.0 ± 66.4 |
WBC (1000/mm3) | 6.3 ± 0.1 | 7.4 ± 1.3 | 7.2 ± 2.0 | 7.1 ± 0.8 | 2.3 ± 7.5 |
RBC (Millin/mm3) | 7.7 ± 0.2 | 8.2 ± 0.4 | 8.3 ± 0.2 | 8.0 ± 0.1 | 7.6 ± 0.6 |
HGB (mg/dL) | 12.2 ± 0.4 | 12.1 ± 0.6 | 12.5 ± 0.3 | 12.2 ± 0.5 | 12.4 ± 1.0 |
HCT (%) | 38.2 ± 1.6 | 38.7 ± 2.2 | 39.8 ± 1.4 | 38.5 ± 1.3 | 40.6 ± 3.3 |
MCV (FL) | 49.3 ± 1.2 | 47.5 ± 0.4 | 47.8 ± 0.7 | 48.1 ± 1.3 | 52.0 ± 0.0 |
MCHC (mol/L) | 31.8 ± 0.2 | 31.3 ± 0.8 | 31.5 ± 0.3 | 31.6 ± 0.3 | 27.4 ± 6.0 |
Plt (1000/mm3) | 1028 ± 334.9 | 943 ± 231 | 1013 ± 143 | 1081 ± 327 | 881 ± 59.3 |