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Table 1 Summary of clinical signs and behavioral response destined to evaluate neurotoxicity before and after rGO i.v administration (7 mg/kg)

From: Reduced graphene oxide: nanotoxicological profile in rats

Autonomic nervous system Peripheral nervous system (neuromuscular) Behavioral (activity) Central nervous system (excitability)
Lacrimation Righting reflex Motor activity Clonic movements
Salivation Hindlimb grip strength Home cage posture Tonic movements
Excretion Forelimb grip strength Rearing  
Piloerection    
  1. All the parameters evaluated in rGO-treated rats showed no discrepancy relative to the observed in rats treated with vehicle (control)
  2. n = 3–5 per time of sampling; n = 5 control group