Fig. 9

Fold expression change in spheroids after 24 h incubation with 3.67 µM mTHPC or 50 nm M-Lipidots and light illumination from 2.5 cm above with white light for 1 min at 3440 lx. Gene expression data was normalized against an untreated control and the RPLP0 house keeping gene. CFTR/MRP ATP-Binding Cassette, Sub-Family C, ABCC1 Member 1, PTGS2 Prostaglandin-Endoperoxide Synthase 2, TXNRD1 Thioredoxin Reductase 1, AKT1 V-Akt Murine Thymoma Viral Oncogene Homolog 1, AKT2 V-Akt Murine Thymoma Viral Oncogene Homolog 2, ATF2 Activating Transcription Factor 2, HIF1A Hypoxia Inducible Factor 1, Alpha Subunit, NFKB1 Nuclear Factor Of Kappa Light Polypeptide Gene Enhancer In B-Cells 1, TP53 Tumor Protein P53, BCL2 B Cell CLL/Lymphoma 2, CDK7 Cyclin-Dependent Kinase 7, CDK9 Cyclin-Dependent Kinase 9, MDM2 MDM2 Proto-Oncogene, E3, EGFR Epidermal Growth Factor Receptor, ERBB2 Erb-B2 Receptor Tyrosine Kinase 2, ERBB3 Erb-B2 Receptor Tyrosine Kinase 3, HDAC1 Histone Deacetylase 1, HDAC2 Histone Deacetylase 2, HDAC4 Histone Deacetylase 4, PIK3C2A Phosphatidylinositol-4-Phosphate 3-Kinase, Catalytic Subunit Type 2 Alpha, PIK3C3 Phosphatidylinositol 3-Kinase, Catalytic Subunit Type 3, PIK3CA Phosphatidylinositol-4,5-Bisphosphate 3-Kinase, Catalytic Subunit Alpha, KRAS Kirsten Rat Sarcoma Viral Oncogene Homolog, V-Ras Neuroblastoma RAS Viral, NRAS Oncogene Homolog, PLK2 Polo-Like Kinase 2, PLK3 Polo-Like Kinase 3, PRKCD Protein Kinase C, Delta, PRKCE Protein Kinase C, Epsilon, RHOB Ras Homolog Family Member B, TOP2B Topoisomerase (DNA) II Beta 180 kDa, CTSB Cathepsin B, TNKS Tankyrase, and Heat Shock Protein 90 kDa Alpha (Cytosolic), Class A Member 1 (HSP90AA1)