Fig. 1
From: Targeted siRNA delivery reduces nitric oxide mediated cell death after spinal cord injury
A Transmission electron micrographs of different siRNA conjugated chitosan NPs. Left siRNA-chitosan NPs, scale bar 0.5 μm. Right Ab-siRNA-chitosan NPs, scale 0.1 μm. B Acute cytotoxicity of cells exposed to siRNA delivered with transfection reagent (TR) after a 4 h exposure time. Morphological based cytotoxicity was observed as cytoplasmic vacuolation, granularity or cellular debris (pseudocolored red). Macrophages treated with siRNA w/TR showed the highest cell death whereas the chitosan vehicles demonstrated minimal cytotoxicity