Scheme 1

Illustration of the stimuli-responsiveness of PPS-PNIPAm block copolymer. a Oxidation-responsiveness of PPS block and temperature-responsiveness of PNIPAm block. b Self-assembling of PPS-PNIPAm micelles and loading with doxorubicin. The PNIPAm corona undergoes shrinkage and collapse above its LCST and PPS core can be furtherly oxidised and release encapsulated DOX molecules. Such drug-loaded nanocarrier can be used in cancer cell delivery and release drug in ROS intracellular environment