Fig. 3

Venn diagram of genome wide gene expression at various treatments conditions and expression profile of select genes. Venn diagram is showing number of differentially expressed (up- or down-regulated) genes following 6 h treatment of Thp1 with a LL-37, CNT–LL-37, CNT and CNT + LL37 and c indolicidin, CNT–indolicidin, CNT and CNT + indolicidin. Validation microarray data by qRT of a few important and select genes of b IL1 signaling pathway in THP-1 cells following treatment with free and conjugated or spiked LL-37 and, d, e TNF signaling pathway in THP-1 cells following treatment with free, nano-conjugated or spiked indolicidin