Table 3 Important genes differentially expressed in THP-1 following 6 h treatments with indolicidin
Gene symbol | Fold changes WRT NT | Entrez Gene ID | Gene functions | |||
|---|---|---|---|---|---|---|
CNT | CNT + Indo | CNT–Indo | Indo-20 | |||
TNFRSF1A | 6.5 | 42.3 | 29.0 | 33.2 | 7132 | Activate NFkB, mediated regulator of inflammation |
RBCK1 | 3.4 | 10.9 | 6.9 | 1.0 | 10616 | Activation of canonical NFkB and the JNK signaling |
SLC11A1 & SLC5A5 | 4.4 | 6.1 | 6.9 | 4.3 | 6556 | Transport of glucose and other sugars, bile salts and organic acids, metal ions and amine compounds |
2.2 | 5.0 | 8.7 | 1.8 | 6528 | ||
ENPP7 | 5.1 | 12.1 | 16.3 | 8.5 | 339221 | Converts sphingomyelin to ceramide |
SOSTDC1 | 2.8 | 2.5 | 5.0 | 2.5 | 25928 | Enhances Wnt and inhibits TGF-beta signaling |
XPR1 | 1.0 | 1.6 | 47.6 | −1.9 | 9213 | G-protein coupled receptor activity |
S100A5 | 69.2 | 67.4 | 150.4 | 113.5 | 6276 | Helps in cell cycle progression and differentiation |
NAPEPLD | 8.0 | 25.7 | 22.6 | 17.7 | 222236 | Responsible for the generation of anandamide, the ligand of cannabinoid and vanilloid receptors |
RGS11 | 2.1 | 3.0 | 5.9 | 1.9 | 8786 | Inhibits signal transduction by G Protein |
RGS6 | 1.0 | −1.6 | 5.9 | 1.5 | 9628 | Inhibits signal transduction by G protein |
RUSC1 | 1.1 | −1.0 | 5.7 | 1.6 | 23623 | Activation of the NFkB pathway |
IBA57 | 2.5 | 4.0 | 4.9 | 1.0 | 200205 | Activates iron-sulfur cluster assembly pathway |
MYO5B | 1.0 | −1.3 | 13.7 | −1.0 | 4645 | Vesicular trafficking with the CART complex |
AOX1 | 2.8 | 2.7 | 4.7 | 2.6 | 316 | Regulation of reactive oxygen species homeostasis |
RIPK4 | 3.7 | 7.3 | 6.9 | 1.4 | 54101 | Plays a role in NF-kappa-B activation |
FILIP1L | 2.0 | 10.6 | 14.0 | 2.2 | 11259 | Leads to inhibition of cell proliferation and migration |
NCOA4 | 2.4 | 5.9 | 10.6 | 5.8 | 8031 | Co-activator of the PPARG |
CREB3L3 | 1.7 | 7.0 | 4.5 | 4.9 | 84699 | Linked to acute inflammatory response |
RASSF2 | 6.5 | 6.7 | 12.2 | 7.3 | 9770 | May promote apoptosis and cell cycle arrest |
DAP | 2.8 | 1.7 | 7.0 | 2.7 | 1611 | Negative regulator of autophagy |
RELA | −1.2 | 1.7 | 8.4 | −1.2 | 5970 | NFkB pleiotropic transcription factor |
CCL20 | 5.5 | 1.5 | 10.9 | 11.0 | 6364 | Antibacterial activity against E. coli and S. aureus |
LYRM4 | 3.3 | 3.4 | 6.2 | 2.2 | 57128 | Nuclear and mitochondrial FE-S protein biosynthesis |
ZDHHC22 | 17.0 | 41.5 | 44.6 | 44.4 | 283576 | Feedback regulator of calcium mediated signaling |
CYP3A5 | 3.7 | 3.6 | 6.9 | 3.7 | 1577 | Oxidizes steroids, fatty acids, and xenobiotics |