Table 4 LL-37 and indolicidin modulates immune genes and pro-apoptotic genes differently
Gene symbol | CNT | CNT + Indo | CNT–Indo | Indo-20 | CNT + LL37 | CNT–LL37 | LL37-20 | Gene description |
|---|---|---|---|---|---|---|---|---|
ANAPC11 | −2.4 | 1.2 | 1.7 | −1.4 | 1 | 1 | 1 | Anaphase promoting complex subunit 11 |
CCL20 | 5.5 | 1.5 | 10.9 | 11 | 1 | 10.1 | 9.2 | Chemokine (C–C motif) ligand 20 |
DEFA3 | 1.1 | 1 | 1.6 | 1.1 | 1 | 1 | 1 | Defensin, alpha 3 |
IL31RA | 1.4 | −6.7 | 1.6 | −1 | 1 | 4.4 | 1 | Interleukin 31 receptor A |
NFATC2 | 3.1 | 2.1 | 4.3 | 1.9 | 1.7 | 4.9 | 12.4 | Nuclear factor of activated T-cells, cytoplasmic, calcineurin-dependent 2 |
NFATC2IP | 1.3 | −1.8 | 2 | 1.1 | 1 | 1 | 1 | Nuclear factor of activated T-cells, cytoplasmic, calcineurin-dependent 2 interacting protein |
PKMYT1 | −1 | −1.4 | 1.6 | −1.3 | 1 | 1 | 1 | Protein kinase, membrane associated tyrosine/threonine 1 (PKMYT1) |
RB1 | −3.3 | −4.1 | 1.6 | 1.6 | 1 | 1 | 1 | Retinoblastoma 1 |
SMAD3 | −1.3 | −2.3 | 2.5 | 1.2 | 1 | 2.5 | 1 | Mad protein homolog |
TGFBR1 | 1 | −1 | 1.5 | −1.1 | 1 | 2.5 | 1.7 | Transforming growth factor, beta receptor 1 |
CHEK1 | −3 | −1.1 | −6.5 | 1.6 | 1 | −3.9 | 1 | CHK1 checkpoint kinase |
CDKN2A | 1.5 | −1.2 | −4.2 | −2 | 1 | 4.6 | 4.3 | Cyclin-dependent kinase inhibitor 2A |
TNFSF4 | 1.1 | 1 | −3.3 | 5.5 | 1 | −3.2 | −2.9 | Tumor necrosis factor (ligand) superfamily, member 4 |
CDC25C | −1 | −1 | −2.9 | 1 | −3.6 | 1 | 1 | Cell division cycle 25 homolog C |
CDC14B | −1 | −1.3 | −2.4 | −1.7 | −3.8 | −7.4 | 1 | CDC14 cell division cycle 14 homolog B |
GADD45B | 1.8 | −1.8 | −2.1 | −2 | 1 | 2.2 | 1.6 | Growth arrest and DNA-damage-inducible, beta |
TLR1 | −4.4 | −1.2 | −1.4 | −1.8 | 1 | 1 | 1 | Toll-like receptor 1 |
TLR3 | 1 | 1 | 2.3 | 1 | 1 | 2.8 | 1 | Toll-like receptor 3 |
TNFAIP3 | −2.5 | −7 | −9 | 1.6 | −4.4 | 1 | 1 | Tumor necrosis factor, alpha-induced protein 3 |
CCL14 | 4.3 | −1.3 | 3.9 | −1.2 | 1 | 1 | 1 | Chemokine (C–C motif) ligand 14 |
BCL2L2 | 1.4 | 2.7 | 2.5 | 1.1 | 1.1 | 3.2 | 1.3 | BCL2-like 2 |
Apaf1 | 4.3 | 1.1 | 1.1 | 1.0 | 1.2 | 1.1 | 1.1 | Apoptotic peptidase activating factor 1 |