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Table 3 NP distribution represented as area-under-the-curve (AUC) (MFI-μm) for each spheroid (LO or HD) and tumor cell type, relative to NP treatment group

From: Distribution of PLGA-modified nanoparticles in 3D cell culture models of hypo-vascularized tumor tissue

Area under the curve (AUC)

Cell line

Unmodified NPs

MPG NPs

PEG NPs

Co-treatment NPs

HeLa

LO [6827 ± 3101]

HD [15,841 ± 1637]

LO [14,339 ± 5129]

HD [47,018 ± 8754]

LO [4042 ± 2101]

HD [23,140 ± 5531]

LO [17,536 ± 2675]

HD [15,657 ± 3579]

CaSki

LO [12,043 ± 5846]

HD [9331 ± 1090]

LO [10,847 ± 2673]

HD [12,364 ± 1485]

LO [6718 ± 1065]

HD [14,297 ± 281]

LO [10,138 ± 2413]

HD [11,847 ± 2231]

SiHa

LO [9377 ± 5219]

HD [14,673 ± 543]

LO [10,186 ± 2887]

HD [24,972 ± 2020]

LO [18,972 ± 1065]

HD [24,237 ± 2532]

LO [19,783 ± 1685]

HD [26,970 ± 5574]

  1. All AUC values represent the average ± standard deviation (n = 3). These data along with statistical significance are presented in Fig. 6 and Additional file 1: Figure S1