Fig. 1

Schematic diagram of synthesis process. Staggered herringbone based microfluidic chip for synthesizing the nanolipomer nanoparticles. The PLGA + drug core is formed by nano-precipitation in the microfluidic chip and introduced from one inlet while the DSPE-PEG lipid coating is injected from the opposite port. The final nanolipomer is collected in the third port after rapid mixing has occurred