Fig. 5
From: Targeting HER2-breast tumors with scFv-decorated bimodal nanoprobes
Endocytic pathway of SPIONs-Cy-PEG and SPIONs-Cy-PEG-scFv in HER2++ BT-474 breast cancer cells. Confocal spectral imaging data on fluorescence of the Cy-labeled nanoprobes, SPIONs-Cy-PEG (A) and SPIONs-Cy-PEG-scFv (B) in BT-474 cells (1 h–37 °C–150 mg/L of iron), C, D electronic microscopies data on SPIONs-Cy-PEG and SPIONs-Cy-PEG-scFv uptake by BT-474 cells (4 h–37 °C–180 mg/L of iron), E flow cytometry data on BT-474 cells after the incubation of Cy-labelled nanoprobes with or without anti-HER2 scFv (15–360 min–37 °C–150 mg/L of iron in PBS)