Journal of Nanobiotechnology

Table 4 Amounts of Ce in liver and kidney tissue after CeO₂ nanoparticle exposure

From: Cerium oxide and barium sulfate nanoparticle inhalation affects gene expression in alveolar epithelial cells type II

Dose group	Ce	Ce content (µg/organ ± SD)
Dose group	Ce	Day 1	Days 28	Days 90 + 1	Days 90 + 28	Days 90 + 90
4 (liver)	Ionic	0.025 ± 0.001	0.27 ± 0.068**	0.717 ± 0.407**	0.68 ± 0.38**	0.46 ± 0.70**
	Particulate	0.054 ± 0.001	0.081 ± 0.04**	1.308 ± 1.094**	1.13 ± 1.58**	0.42 ± 0.24*
	Total	0.079 ± 0.002	0.34 ± 0.049**	2.025 ± 1.182**	1.81 ± 1.78**	0.88 ± 0.60*
5 (liver)	Ionic	< 0.025	0.35 ± 0.038**	1.30 ± 0.45**	1.03 ± 0.43**	1.26 ± 1.13**
	Particulate	< 0.025	0.13 ± 0.080	1.65 ± 3.00*	1.40 ± 1.61**	0.54 ± 0.31**
	Total	< 0.025	0.48 ± 0.078**	2.95 ± 3.04**	2.43 ± 1.50**	1.45 ± 0.85**
4 (kidney)	Ionic	0.11 ± 0.06	0.11 ± 0.07	0.04 ± 0.01	0.04 ± 0.01	0.05 ± 0.03
	Particulate	0.04 ± 0.03	0.07 ± 0.03	0.15 ± 0.10*	0.07 ± 0.02	0.05 ± 0.02
	Total	0.15 ± 0.07	0.18 ± 0.10	0.19 ± 0.09	0.11 ± 0.02	0.09 ± 0.05
5 (kidney)	Ionic	0.018 ± 0.001	0.025 ± 0.000	0.032 ± 0.012**	0.041 ± 0.009**	0.059 ± 0.015**
	Particulate	0.025 ± 0.010	0.021 ± 0.006	0.030 ± 0.003	0.033 ± 0.029	0.042 ± 0.02
	Total	0.029 ± 0.011	0.033 ± 0.018	0.050 ± 0.019	0.073 ± 0.033*	0.084 ± 0.038*

Dose groups: 4 = 1.0 mg/m³ CeO₂, 5 = 3.0 mg/m³ CeO₂; Values are expressed as mean ± SD, * p < 0.05, ** p < 0.01 vs. d 1, n ≤ 5; Kruskal–Wallis–ANOVA with Mann–Whitney U-test as post hoc analysis; detection limit for analysis of liver tissue: 0.025 µg; detection limit for analysis of kidney tissue: 0.015 µg

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ISSN: 1477-3155

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