Fig. 5

Characterisation of the potential interaction between solid drug nanoparticles and lymphocyte function. PBMC were treated with either efavirenz aqueous solution or efavirenz s for 24 h before their proliferative capacity (a), cytokine secretion (b) and surface marker expression in CD4+ (c) and CD8+ (d) cells were determined. Data expressed as mean ± standard deviation (N = 5); *P < 0.05, **P < 0.01, ***P < 0.001 as compared to untreated control whereas ^$P < 0.05, ^$$P < 0.01, ^$$$P<0.001 compared to positive control