Fig. 5

Stability of free PDCs and PDC-PEG-AuNPs. Chemostability was assessed by incubation the constructs in 0.01 M phosphate buffer solution pH 7.2 at 37 °C for different time intervals. Biostability was assessed by incubation in a mouse liver homogenate at 37 °C. At the indicated time intervals, aliquots were taken, filtered or centrifuged (respectively) and analyzed by LC–MS for PDC integrity. Graphs a and c represent results for PDCs while graphs b and d represents results for Au-PEG-PDCs. Results are expressed as mean % PDC integrity ± standard error, calculated from two independent experiments