Table 1 Up regulation and downregulation of various miRNA in diseased state

Humans

 miR-660-3p, miR-665, miR-1285-3p and miR-4491, miR-21, miR-29b, miR-34, miR-122, miR-129, miR-142-3p, miR-199, miR-210, miR-211, miR-212, miR-379, miR-423-5p and miR-503

Up

Chronic heart failure

[47,48,49]

 miR-221-30, miR-487b-3p, miR-4288, miR-30, miR-107, miR-125b, miR-126, miR-139, miR-142-5p, miR-182, miR-497 and miR-526

Down

Chronic heart failure

[47,48,49]

 miR-133 and miR-208a

Up

Coronary artery disease

[50]

 miR-126, miR-17, miR-92a, miR-145 and miR-155

Down

Coronary artery disease

[50]

 miR-24, miR-21, miR-20b, miR-15a, miR-126, miR-191, miR-197, miR-223, miR-320, miR-486, miR-150, miR-29b, miR-206 and miR-133a

Down

Type-II diabetes

[51, 52]

 miR-28-3p, miR-9, miR-29a, miR-30d, miR34a, miR-124a, miR-146a and miR375

Up

Type-II diabetes

[51, 53]

 miR-150, miR-27a, miR-192, miR-320a and miR-375

Up

Type-II diabetes

[54]

 miR-152, miR-30a-5p, miR-181a, miR-24, miR-148a, miR-210, miR-27a, miR-29a, miR-26a, miR-27b, miR-25 and miR-200a

Up

Type-I diabetes

[55]

 miR-21a, miR-93, miR-31, miR-9, miR-34a, miR-155, miR-181a and miR-199a

Down

Type-I diabetes

[56, 57]

 miR-29a, miR-122, miR-132,

Down

Gestational diabetes mellitus

[58]

 miR-29aand miR-92a

Up

Colorectal cancer

[59]

 mir-009-1, mir-155, mir-213 and mir-102

Up

Breast cancer

[60]

 mir-010b, mir-021, mir-034, mir-123, mir-125a, mir125b-1, mir-140-as, mir-145, mir-194 and mir-204

Down

Breast cancer

[60]

 miR-200a, miR-200b, miR-200c, miR-141, miR-205, miR-21 and miR-182

Up

Ovarian cancer

[61]

 mir-124a, mir-211, mir-216, mir-302c, mir-145, mir-29c, mir-181a, mir-302, let-7c, mir-98, mir-19b, mir-29b, mir-18a, mir-154, mir-19a, mir-153, mir-144, mir-222, mir-302a, mir-204, mir-101-1, mir-214, mir-34c, mir-374, mir-195, mir-215, mir-28, mir-29a, mir-133b, mir-299-5p, mir-7-2, let-7f, mir-139, mir-193, mir-323, mir-134, mir-370, let-7d, mir-100, mir-101, mir-105, mir-125a, mir-125b-1, mir-126, mir-133a, mir-137, mir-140, mir-143, mir-147, mir-199a, mir-199b, mir-224, mir-302b, mir-9 and mir-99a

Down

Ovarian cancer

[61]

 miR-20, miR-21, miR-99a, miR-141, miR-182, miR-198, let-7a, miR-148a, miR-200c, miR-375, miR-96, miR-141, miR-145, miR-155, miR-34, miR-34c, miR-187, miR-221 and miR-224

Up

Prostate cancer

[62,63,64,65,66]

 miR-145, miR-155, miR-143, miR-223, miR-149, miR-181b, miR-205, let-7a and miR-182

Down

Prostate cancer

[62,63,64,65,66]

 miR-30e, miR-181b, miR-34a, miR-346 and miR-7

Up

Schizophrenia

[67]

 miR-151a-3p, miR-181b-5p, miR-320a, miR-328, miR-433, miR-489, miR-572 and miR-663a

Down

Autism

[68]

 miR-101-3p, miR-106b-5p, miR-19b-3p, miR-195-5p, miR-130a-3p and miR-27a-3p

Up

Autism

[68]

 miR-98-5p, miR-885-5p, miR-483-3p, miR-342-3p, miR-191-5p and miR-let-7d-5p

Down

Alzheimer’s

[69]

 miR-194-5p, miR-301a-3p, miR-30b-5p, miR-342-5p and miR-4446-3p

Down

Drug resistant epilepsy

[70]

Animals

 bta-miR-15b, bta-miR-17-3p, bta-miR-16b, bta-miR-148a, bta-miR-26b, bta-miR-101, bta-miR-29b, bta-miR-27b and bta-miR-215

Cow

Up

Bovine metritis

[71]

 bta-miR-148b, bta-miR-199a-3p, bta-miR-122, bta-miR-200b and bta-miR-10a

Cow

Down

Bovine metritis

[71]

 mir-19b

Pig

Down

PPV infection

[72]

 bta-mir-100

Cow

Up

S. uberis infection

[73]

 bta-mir-19b, bta-mir-19b-2, bta-mir-1271, bta-mir-100, bta-mir-301a, bta-mir-32, Novel-14_7917

Cattle

Down

Paratuberculosis

[74]

 bta-mir-6517, bta-mir-7857

Cattle

Up

Paratuberculosis

[74]

 bta-miR-24-3p

Cattle

Up

Mycoplasma bovis infection

[75]

 bta-miR-92a, miR-92a

Cattle

Down

Mycoplasma bovis infection

[75]

Plants

 vvi-miR395a-m, vvi-miR398b-c, vvimiR408, ccamiR408, c31052, c141107, c141224 and c205570

Grapevine

Up

Leaf roll associated virus-3 infection

[76]

 miR171

Arabidopsis

Down

Viral infection

[77]

 miR156, miR157, miR158, miR162, miR164, miR167 and miR171

Arabidopsis

Up

Turnip yellow mosaic virus

[78]

 miR393

Arabidopsis

Up

P. syringae

[79]

 miR393

Soybean

Up

P. sojae

[80]

 miR482, miR1448, miR1971 and miR2118

Cotton

Down

Vetricillium

[81, 82]

 miR156, miR159, miR164, miR168

Wheat

Down

Erysiphe graminis f. sp. Tritici

[83]

 miR156, miR159, miR164, miR168, miR169, miR172, miR393, miR396, miR482, miR1448, Phe-SR3, Phe-SR23, Phe-SR25

Populus beijingensis

Up

Dothiorella gregaria

[84]

 miR156, miR162, miR398 and miR408

Papaya

Up

Papaya meleria

[40]

 miR845 and miR811

Maize

Up

Exserohilum turcicum

[39]

 osa-miR812j, osa-miR5072, osa-miR444a-5p, osa-miR396c-3p, osa-miR1870-5p, osa-miR1863b.2, osa-miR172d-5p, osa-miR171c-3p, osa-miR167a-5p, osa-miR166d-5p, osa-miR159b, osa-miR156-3p, osa-miR15a, osa-miR1432-5p, osa-miR1432-p, osa-miR1429-5p, osa-miR1432-3p, osa-miR1429-5p, osa-miR1425-3p, osa-miR1423-5p and osa-miR1320-5p

Rice

Up

Rice stripe rust virus

[41]

 miR156a, miR156156b, miR156c, miR156d, miR156e, miR156 h, miR159e, miR319a, miR395a, miR395b, zju-miRn23 and zju-miRn24

Ziziphus jujube

Up

Witches’-Broom phytoplasma

[42]

 miR159a, miR172, miR2111, miR2950, miR399, miR477, miR858b, zju-miRn2, zju-miRn8 and zju-miRn16

Ziziphus jujube

Down

Witches’-Broom phytoplasma

[42]

 slmiR4828 and slmiR5300

Motelle

Down

F. oxysporum

[43]