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Fig. 2 | Journal of Nanobiotechnology

Fig. 2

From: Kinetics of mRNA delivery and protein translation in dendritic cells using lipid-coated PLGA nanoparticles

Fig. 2

A variety of different microscopic methods used to visualize blank LPNs (a1a4) and CS-PLGA NPs (b1b4). a1, b1 SEM images show a smooth, spherical morphology of the nanoparticles, a2, b2 TEM images of particles without staining give a hint about the core–shell structure, seen in a dark electron dense layer surrounding a brighter core. a3, b3 To emphasis this structure and increase the contrast, the particles were stained with 0.5% wt/V PTA and imaged with TEM and further unstained nanoparticles were visualized with a less harsh method using Cryo-TEM with red arrows pointing to the particles (a4, b4). Scanning electron microscopy (SEM), transmission electron microscopy (TEM)

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