Table 1 Properties of the liposomal formulation of carboplatin
ID | Chemical | Lipids molar ratio | Properties | Zeta potential (mV) | Method | Size (nm) | mg carboplatin mg lipids |
|---|---|---|---|---|---|---|---|
L1 | DPPC:DC-Chol | 1:1 | cationic | 52.1 ± 8.84 | REV | 60.3 ± 21.1 | 0.050 |
L1′ | DPPC:DC-Chol | 1:1 | cationic | 55.9 ± 9.38 | REV | 57.4 ± 16.1 | – |
L1″ | DPPC:DC-Chol | 1:1 | cationic | 38.9 ± 12.9 | Hydration | 77.7 ± 21.0 | – |
L2 | DPPC:DC-Chol: PEG2000 PE | 10:11:1 | cationic + PEG | 45.1 ± 12.6 | REV | 71.3 ± 17.8 | 0.032 |
L3 | DSPC:DSPG:Chol | 7:2:1 | anionic | − 48.0 ± 15.0 | Hydration | 72.7 ± 24.3 | 0.096 |
L3′ | DSPC:DSPG:Chol | 7:2:1 | anionic | − 47.3 ± 14.6 | Hydration | 83.6 ± 17.2 | – |
L4 | DPPC:Chol:PEG2000 PE | 10:11:1 | anionic + PEG | − 35.8 ± 5.43 | REV | 85.6 ± 19.9 | 0.32 |
L4′ | DPPC:Chol:PEG2000 PE | 10:11:1 | anionic + PEG | − 33.0 ± 6.27 | REV | 77.4 ± 24.3 | – |