Fig. 1

In vivo detection of IO/HSA NPs by MRI in a representative rat. The rat received a 5 µl suprachoroidal injection of IO/HSA NPs in the right eye. The left eye was not injected and was used as control. MRI was performed at 7 hours (a), and 1, 7, 13, 22 and 30 weeks (b–f) following injection. Red arrows highlight the hypointense areas on the T2* sequence at the back of the eye in the injected eye. h hours, W weeks