Table 4 IC₅₀, Combination Index (CI) and Dose Reduction index (DRI) values of free RSV, free PMT and free RSV/PMT co-solvent compared to the prepared nano-formulations on MDA-MB-231 breast cancer cell line at the concentration of 0–60 μg/ml after 24 h

RSV

–

–

25.28

–

–

–

PMT

–

–

–

21.06

–

–

Blank NPs

–

–

–

–

–

28,128

RSV/PMT

1.04

17.11

9.65

7.54

2.61

2.79

F1 [RSV/PMT-BSA NPs]

0.975

14.25

8.03

6.28

3.14

3.35

F2 [RSV/PMT-BSA-QDs NPs]

0.931

13.24

7.46

5.83

3.38

3.60

F3 [Mann-targeted RSV/PMT-BSA-QDs NPs]

0.873

10.96

6.18

4.83

4.08

4.35

F4 [Mann-targeted RSV/PMT-BSA NPs]

0.910

11.13

6.27

4.90

4.02

4.29