Fig. 5

miR-210 and VEGF levels in the lesion region were upregulated by administration of RGD-exo loaded with miR-210 and alleviated the mortality after MCAO/R. a Intravenous administration of PBS, Scr-exo:miR-210, RGD-exo, RGD-exo loaded with negative control (RGD-exo:NC), or RGD-exo loaded with miR-210 (RGD-exo:miR-210) was performed on mice subjected to 1 h of MCAO and 24 h of reperfusion. miR-210 in the lesion region was analyzed 12 h after administration (36 h after reperfusion). N ≥ 3. The data are expressed as the mean ± SEM. ^#P < 0.05, and ^##P < 0.01 by one-way ANOVA. b The mRNA level of VEGF was examined 24 h after administration (48 h after reperfusion). The sham group was used as the control. N ≥ 3. The data are expressed as the mean ± SEM. **P < 0.01 compared with sham, ^#P < 0.05 and ^##P < 0.01 compared with RGD-exo:miR-210 by one-way ANOVA. c The survival percentages of the mice that received MCAO/R followed by RGD-exo:NC or RGD-exo:miR-210 administration