Table 1 Examples of folic acid receptor-targeted nanosystems
From: Nanocomposites as biomolecules delivery agents in nanomedicine
Type of nanomaterial | Functionalization | Cargo | Justification | Efficacy test | References |
|---|---|---|---|---|---|
Abraxane® | FA | PTX, difluorinated curcumin | Targeted delivery system | SKOV-3, HeLa cells | [87] |
Graphene oxide | Pluronic 127 | Cy5.5 | Fluorescence imaging | KB human epithelial mouth carcinoma cells KB tumor bearing mice | [88] |
Graphene oxide | PEG | Fluorescein-labeled peptide with a recognizable sequence of DEVD, Camptothecin, curcumin, evodiamine, silybin | High-contrast caspase-3 activity imaging | HeLa cells HeLa tumor-bearing BALB/c nude mice | [89] |
Graphene oxide | β-Cyclodextrin | DOX | Targeted delivery system | HeLa cells | [90] |
Graphene oxide | PAMAM | DOX | Targeted delivery system | HeLa cells | [91] |
Graphene oxide | Polyvinylpyrrolidone | DOX | Targeted chemo-photothermal therapy | HeLa cells | [92] |
Graphene oxide | Chlorine e6 | Targeted photodynamic therapy | MGC803 | [93] | |
Graphene oxide | PEG, phospholipids | Resveratrol | Targeted chemo-photothermal therapy | MCF-7 cells Male athymic BALB/c mice | [94] |
Reduced graphene oxide | DOX | Targeted delivery system | MDA-MB 231 cells | [95] | |
Reduced graphene oxide | Poloxamer 407 | Docetaxel, irinotecan | Targeted chemo-photothermal therapy | MCF-7, HepG2 cells | [96] |
Graphene oxide/Fe3O4 | Thiolated chitosan | Coumarin 6 | Targeted chemo-photothermal therapy | HeLa cells | [97] |
Graphene oxide/Fe3O4 | DOX | Targeted chemotherapy | SK3 | [98] | |
Graphene oxide/Fe3O4 | Chitosan | DOX | Targeted chemotherapy | [99] | |
Graphene oxide/gold | DOX | Targeted chemo-photothermal therapy | MCF-7 cells, HeLa cells Balb/c mice, New Zealand White rabbits | [100] | |
Lipid core nanocapsules | DOX, tanespimycin | Sequential delivery of DOX and tanespimycin, sensitize the cancer cells to the cytotoxic effects of DOX | MCF-7 cells | [101] | |
Poly(lactic-co-glycolic acid) (PLGA) | PEG, phospholipids | Boron-curcumin complex, gadolinium | Antiproliferative effect Neutron capture therapy, MRI imaging | IGROV-1 cells | [102] |
PAMAM | PEG | Oxaliplatin | Targeted delivery system | SW 480, MSC | [103] |
Polyphosphoester | DOX | Targeted delivery system | HeLa cells | [104] | |
Methoxy poly(ethylene glycol)-b-copolycarbonates | DOX | Targeted delivery system | HeLa cells, COS-7 cells | [105] | |
Chitosan | Hesperetin | Targeted delivery system | HCT15 cells | [106] | |
Chitosan | Oleic acid | Bromopyruvate | Targeted delivery system | HLF cells | [107] |
Chitosan | Poly(2-dimethylaminoethyl methacrylate), casein coated iron oxide | 5-Fluorouracil | Targeted delivery system | L929, MCF-7, MDA-MB-231 cells | [108] |