Table 5 Examples of hyaluronic acid-containing nanovectors
From: Nanocomposites as biomolecules delivery agents in nanomedicine
Type of nanomaterial | Cargo | Justification | Efficacy test | References |
|---|---|---|---|---|
GO/RGD | DOX | Chemotherapy | SCOV-3 cells | [213] |
Carbon dots/PEI | Plasmid pGL-3 and pEGFP-N1 | Fluorescent imaging | HeLa cells | [214] |
Carbon dots/PEI/mesoporous silica | GOX HAase DOX | Chemotherapy Fluorescent imaging | A549 cells | [51] |
Octadecylamine conjugate | Methotrexate Curcumin | Chemotherapy Fluorescence imaging | HeLa cells | [215] |
PLGA | Docetaxel Sulforaphan | Chemotherapy | MCF-7 cell BALB/c nude mice | [216] |
PLGA | Salinomycin Paclitaxel | Chemotherapy | MCF-7 cell MDA-MB-231 cells | [217] |
PLGA | Paclitaxel Curcumin | Chemotherapy | MCF-7 cell BALB/c nude mice | [218] |
PLGA | Paclitaxel | Chemotherapy | MDA-MB-231 cells | [219] |
PLGA/PEG | IC87114-quinazolinone purin | Chemotherapy | MiaPaca-2 cells | [220] |
PLGA | Chlorine e6, Gd3+ | Photodynamic therapy, MRI | A549 cells | [221] |
Arginine based poly(ester amide)s | Chlorine e6 | Photodynamic therapy | MDA-MB-231 | [222] |
PLGA/tocopherol | Docetaxel | Chemotherapy | A549 cells BALB/c nude mice | [223] |
Magnetic Prussian blue/CuInS2/ZnS quantum dots/BSA | Fluorescence imaging MRI | HeLa cells BALB/c nude mice | [224] | |
HA | IR-780-NH2 dye | Fluorescence imaging | MB-49 cells C57BL/6 mice | [212] |
Heptamethine cyanine-conjugated HA micelles | IR-808 dye | Fluorescence and photoacoustic imaging | A549 cells BALB/c nude mice | [170] |
Diketopyrrolopyrrole derivative | Photodynamic therapy | HCT-116 cells HCT-116 tumor-bearing mice | [225] | |
Maillard reaction-based conjugates of HA and BSA micelles | Paclitaxel Imidazoacridinones | Chemotherapy | SKOV-3 cells | [226] |
HA-ceramide/Soluplus | Resveratrol | Chemotherapy Fluorescence imaging | MDA-MB-231 BALB/c nude mice | [227] |
HA | 10-Hydroxycamtothecin | Chemotherapy | MDA-MB-231cells HT29 cells A549 cells HepG2 cells MDA-MB-435 cells Athymic nude mice | [228] |
HA nanogel | Cytochrome c | Chemotherapy | MCF-7 cells Nude mice | [229] |
HA nanoemulsion | Paclitaxel | Chemotherapy | Nude mice | [230] |
HA-tocopherol succinate micelles | Paclitaxel | Chemotherapy | B16F10 cells and L-02 cells B16F10 tumor-bearing C57BL/6 mice | [231] |
HA functionalized liposomes | DOX | Chemotherapy | MG63 cells Balb/c nude mice | [232] |
HA modified liposomes/RGD | DOX | Chemotherapy | B16F10 cells MCF-7 cells C57BL/6 mice | [233] |
HA functionalized liposomes/magnetic NPs | Docetaxel | Chemo-photodynamic therapy | MCF-7 cells | [234] |
SPIONs | A459 cells | [235] | ||
HA/deoxycholic acid/histidine micelles | Paclitaxel | Chemotherapy | MCF-7 cells Nude mice | [236] |
HA/tocopherol micelles | Paclitaxel | Chemotherapy | SCOV-3 cells | [237] |
Chitosan | 5-FU | Chemotherapy | A549 cells | [238] |
Chitosan | Docetaxel | Chemotherapy | MCF-7 cell | [239] |
Mesoporous silica | Paclitaxel | Chemotherapy | MCF-7 cell Balb/c nude mice | [240] |
Mesoporous silica/RGD | Chlorambucil | Chemotherapy | SCOV-3 cells | [241] |
Mesoporous silica | DOX | Chemotherapy | HeLa cells | [242] |