Fig. 1

SH-SY5Y cells were differentiated with retinoic acid (RA) or staurosporine (ST). Undifferentiated cells were grown in parallel. SiPCL-NP-exposure was performed at a concentration of (2.6 × 10¹⁰ NPs/ml) for 24 h at day in vitro (DIV) 1 (a), DIV4 (b) or DIV6 (c). Cell viability was analyzed on DIV7 in undifferentiated and differentiated cells. The data represents the mean percentage (%) of the cell viability in relation to the respective controls. Error bars correspond to SEM. Significant differences between control- and NP-exposed-groups are labeled with asterisks (*p ≤ 0.05; **p ≤ 0.01; ***p ≤ 0.001; ****p ≤ 0.0001)