Table 1 Characterization of different molecular weight PLGA nanoparticle (NP) preparations containing PS-155 for mean size (DLS diameter), surface charge (zeta potential) and polydispersity index (PDI)
PLGA polymer (50:50) | Formulations | Inherent viscosity (dL/g) | PLGA mol. wt. (kDa) | Zeta potential (mv ± SD) | Hydrodynamic diameter (DLS) (nm ± SD) | PDI |
|---|---|---|---|---|---|---|
Acid terminated | NP-1 | 0.15–0.25 | 6.7–12.9 | − 24.5 ± 1.2 | 280 ± 80 | 0.13 ± 0.06 |
NP-2 | 0.55–0.75 | 21.0–43.5 | − 26.5 ± 2.0 | 376 ± 15 | 0.16 ± 0.05 | |
Ester terminated | NP-3 | 0.15–0.25 | 6.70–12.9 | − 20.2 ± 4.8 | 358 ± 70 | 0.26 ± 0.09 |
NP-4 | 0.26–0.54 | 12.9–21.0 | − 22.4 ± 4.8 | 351 ± 70 | 0.17 ± 0.08 | |
NP-5 | 0.65 | 43.5 | − 23.3 ± 4.6 | 430 ± 137 | 0.19 ± 0.13 | |
NP-6 | 0.95–1.2 | 73.7–91.6 | − 18.3 ± 2.3 | 536 ± 32 | 0.16 ± 0.008 |