Fig. 5
From: Synthesis and biomedical applications of nanoceria, a redox active nanoparticle
Schematic diagram of drug delivery activity of nanoceria in the cancer cell. Drug @ CNP coated with specific targeting agent is up taken by the cell through endocytosis. Due to low pH and high GSH in endosome, and lysosome drug is released into the cytoplasm and then enter either into nucleus directly and bind with DNA that causes its denaturation or in mitochondria which increased the production of ROS that further attack the nucleus and causes denaturation of DNA, which ultimately lead to cell death