Fig. 2

Particle size distribution of afatinib or miR-139 in various LPNs. a A schematic diagram for the preparation of peptides-conjugated Afa/LPN. Cumulative size distribution of b Afa/LPN; c Afa/LPN-H; d Afa/LPN-R; e Afa/LPN-HR at pH 7.4; f Afa/LPN-HR at pH 6.5; g miR-139/LPN-HR at pH 7.4; h miR-139/LPN-HR at pH 6.5 were measured by Zetasizer. Afa/LPN-HR and miR-139/LPN-HR were diluted at pH 7.4 or 6.5 PBS before measurement