Fig. 3
(this figure was reproduced from Scott et al. [29] with the required copyright permission)
a Correlation between blood clearance, tumor penetration, plasma half-life and renal uptake and the previously discussed antibodies and antibody fragments of different size: bsAbs, intact MAbs, scFv, sdAbs and alternative protein scaffolds. Uptake is expressed as percentage of injected dose per gram (ID/g). b PET/computed tomography (CT) images of mice bearing prostate stem-cell antigen (PSCA)–expressing LAPC-9 prostate cancer xenografts. PSCA expression was visualized with intact mAbs, single-chain Fv–Fc (scFV-Fc) wild type (WT) mAbs, scFV-Fc double mutant (DM) mAbs, Minibodies and Diabody labeled with N-succinimidyl-4-[18F]-fluorobenzoate (18F-SFB). All microPET images were scaled individually to best show tumor targeting