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Fig. 2 | Journal of Nanobiotechnology

Fig. 2

From: Functional exosome-mediated co-delivery of doxorubicin and hydrophobically modified microRNA 159 for triple-negative breast cancer therapy

Fig. 2

Internalization of Dox and Cy5-Cho-miR159 mediated by Exo or A15-Exo. A Intracellular uptake of PKH67-labeled Exo or A15-Exo by MDA-MB-231 and B16 cells, as determined by flow cytometry. (a, b) Flow cytometry data. (c) Quantitative analysis of the percentage of PKH67-positive cells and mean fluorescence intensity. B Cellular uptake of Dox mediated by Exo or A15-Exo. Quantitative analysis of the mean fluorescence intensity of Dox in (a) MDA-MB-231 and (b) B16 cells. (c) Quantitative analysis of the percentage of Dox-positive cells. C Cellular uptake of Cy5-miRNA or Cy5-Cho-miRNA mediated by Exo or A15-Exo. Quantitative analysis of the mean fluorescence intensities of Cy5-miRNA or Cy5-Cho-miR159 in MDA-MB-231 (a) and B16 (b). (c) Quantitative analysis of the percentages of Cy5-miRNA- and Cy5-Cho-miR159-positive cells

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