Dynamic profiles, biodistribution and integration evaluation after intramuscular/intravenous delivery of a novel therapeutic DNA vaccine encoding chicken type II collagen for rheumatoid arthritis in vaccinated normal rodent

Table 1 The identification of genomic integration of CCOL2A1 gene in vaccinated normal rats on day 42 after vaccination following single intramuscular injection (N = 6)

Values ≤ LOD (182 PCN/µg DNA) indicate a negligible risk of CCOL2A1 gene integration. “UD” respresent “undetermined”. A panel of 10 tissues/organs were harvested and processed for qPCR determination. These data are representative of three experiments. Three separate experiments yielded similar results

ISSN: 1477-3155