Fig. 7

The distribution of codelivery NPs in vivo. a Fluorescence images after intravenous injection at various times. Compared with the main distribution of Dir in the abdominal cavity in the unbound Dir group, Dir-NPs and Dir-NPs-RGD were mainly distributed in MDR tumor tissues (red circle) and the abdominal cavity over time, suggesting better tumor targeting by RGD-NPs. b Quantitative average fluorescent intensities in MDR tumors after intravenous injection. *P < 0.05, **P < 0.01, ***P < 0.001, compared with unbound Dir group. c Ex vivo fluorescence images of the isolated MDR tumors, hearts, livers, spleens, lungs and kidneys after intravenous injection after 48 h. d The mean quantitative fluorescence intensity of the isolated organs in all groups. The fluorescence of Dir-NPs-RGD group in tumor was significantly stronger than that of the Dir-NPs and unbounded Dir groups, along with the relatively lower concentration of Dir in other normal tissues and organs