Fig. 8

Anticancer efficacy and preliminary safety evaluation in resistant cancer xenografts. a Tumor images (1) and tumor growth inhibition graph (2) and tumor weight (b) for a murine model with A549/ADR xenografts after intravenous injection with the different formulations. c The tumor inhibitory rate (TIR). The TIR is calculated using the following equation: TIR (%) = [1 − X/Y] × 100%. X, the average weights of the tumors from the experimental groups; Y, the average weights of the tumors from control groups). d The expression of cytochrome C of the tumor tissues by immunohistochemistry assay. Images of lung cancer metastasis (e1) and tumor number (e2) for a murine model with 4T1/ADR xenografts after intravenous injection with the different formulations. Body weight (f) and H&E (g) stained organ slices from the A549/ADR-bearing nude mice treated with all formulations in vivo. The data are presented as the means ± standard deviations (n = 5); *P < 0.05, ^#P < 0.001 compared with TPH/PTX nanomicells; **P < 0.05, compared with TP/PTX nanomicells